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1.发明授权Low-irritation antiperspirant and deodorant compositions containing a volatile, nonpolar hydrocarbon liquid 失效含有挥发性非极性烃类液体的低刺激性止汗剂和除臭剂组合物
公开(公告)号：US5976514A
公开(公告)日：1999-11-02
申请号：US197146
申请日：1998-11-20
IPC分类号： A61K8/26 , A61K8/28 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/58 , A61K8/73 , A61K8/89 , A61K8/891 , A61K31/74 , A61Q15/00 , A61K7/32 , A61K7/00 , A61K7/34 , A61K7/38
摘要： Disclosed are topical compositions which comprise from about 0.01% to about 60% by weight of an antiperspirant and/or deodorant active; from about 1% to about 60% by weight of a volatile, nonpolar hydrocarbon liquid having a solubility parameter of less than about 7.5 (cal/cm.sup.3).sup.0.5 and a vapor pressure as measured at 25.degree. C. of from about 0.01 mmHg to about 6.0 mmHg; and from about 1% to about 60% by weight of a skin irritation-mitigating material having a vapor pressure equal to or less than that of the volatile, nonpolar hydrocarbon liquid, preferably a silicone-containing liquid; wherein the weight ratio of the volatile, nonpolar hydrocarbon liquid to the mitigating material is from about 5:1 to about 1:50. It has been found that the volatile, nonpolar hydrocarbon liquid as defined herein can cause skin irritation when used in an antiperspirant or deodorant composition, even when used at relatively low concentrations, but that the skin irritation can be reduced or eliminated by the addition of a skin irritation-mitigating material, provided the material has the requisite vapor pressure and weight ratio relative to the volatile, nonpolar hydrocarbon liquid.
摘要翻译： 公开了包含约0.01重量％至约60重量％的止汗剂和/或除臭剂活性剂的局部组合物; 约1％至约60％重量的溶解度参数小于约7.5（cal / cm 3）0.5的挥发性非极性烃液体，在25℃下测量的蒸气压为约0.01mmHg至约 6.0 mmHg; 和约1重量％至约60重量％的蒸气压等于或小于挥发性非极性烃液体，优选含硅酮液体的皮肤刺激缓解材料; 其中挥发性非极性烃液体与缓和材料的重量比为约5:1至约1:50。 已经发现，当在止汗剂或除臭剂组合物中使用时，如本文所定义的挥发性非极性烃液体即使在相对低的浓度下使用也可能引起皮肤刺激，但是通过加入皮肤刺激可以减少或消除皮肤刺激 皮肤刺激缓解材料，只要材料相对于挥发性非极性烃液体具有必要的蒸汽压力和重量比。
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公开(公告)号：US06171601B2
公开(公告)日：2001-01-09
申请号：US08771563
申请日：1996-12-20
IPC分类号： A61K732
CPC分类号： A61K8/042 , A61K8/0229 , A61K8/342 , A61K8/365 , A61K8/39 , A61K8/42 , A61K8/585 , A61K2800/31 , A61Q15/00
摘要： Disclosed are anhydrous antiperspirant gel-solid stick compositions which comprise a particulate antiperspirant active; a solid non-polymeric gellant that is substantially free of dibenzylidene alditol, n-acyl amino acid derivatives, organic polymeric gellants, and inorganic thickening agents; and an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm3)0.5 wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram-force to about 5,000 gram-force, a ratio of an elastic to viscous moduli of from about 0.1 to about 100. The refractive indices of the particulate antiperspirant active, solid non-polymeric gellant, and anhydrous liquid carrier are not matched. The solid non-polymeric gellant is preferably a crystalline material having an average particle size of less than about 1 &mgr;m, and/or has an elongated particle morphology having an aspect ratio of greater than about 2. These antiperspirant gel-solid stick compositions provide improved low residue performance, antiperspirant and aesthetics.
摘要翻译： 公开了包含颗粒止汗活性物质的无水止汗凝胶 - 固体棒组合物; 基本上不含二亚苄基糖醇，正酰基氨基酸衍生物，有机聚合物胶凝剂和无机增稠剂的固体非聚合物胶凝剂; 和平均溶解度参数为约3至约13（cal / cm 3）0.5的无水液体载体，其中组合物的可见残留指数为约11至约30L值，产品硬度为约500克 强度为约5,000克力，弹性粘度模量的比率为约0.1至约100.颗粒止汗剂活性固体非聚合物胶凝剂和无水液体载体的折射率不匹配。 固体非聚合物胶凝剂优选是平均粒度小于约1μm的结晶材料，和/或具有长宽比大于约2的细长颗粒形态。这些止汗凝胶 - 固体棒组合物提供改进的 低残留性能，止汗剂和美观。
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公开(公告)号：US6123932A
公开(公告)日：2000-09-26
申请号：US332215
申请日：1999-06-14
申请人： Gerald John Guskey , Dennis Ray Bacon , Prem Sagar Juneja , Curtis Bobby Motley , George Peter Rizzi
发明人： Gerald John Guskey , Dennis Ray Bacon , Prem Sagar Juneja , Curtis Bobby Motley , George Peter Rizzi
IPC分类号： A61K8/00 , A61K8/27 , A61K8/33 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/42 , A61K8/58 , A61K8/73 , A61Q15/00 , A61K7/32 , A61K7/00 , A61K31/74 , A61L9/00
CPC分类号： A61K8/042 , A61K8/738 , A61Q15/00 , A61K2800/31
摘要： Disclosed are aqueous and anhydrous deodorant compositions which comprise from about 0.1% to about 89.9% by weight of a cyclodextrin odor controlling agent, from about 0.1% to about 30% by weight of a solid non-polymeric gellant and from about 10% to about 90% by weight of an aqueous or anhydrous liquid carrier. Also disclosed are methods of using and making the compositions. The disclosed compositions are especially effective at preventing or eliminating malodors resulting from perspiration.
摘要翻译： 公开了含水和无水除臭剂组合物，其包含约0.1重量％至约89.9重量％的环糊精气味控制剂，约0.1重量％至约30重量％的固体非聚合胶凝剂和约10重量％至约10重量％ 90重量％的水性或无水液体载体。 还公开了使用和制备组合物的方法。 所公开的组合物特别有效地防止或消除由汗液引起的恶臭。
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公开(公告)号：US06174521B1
公开(公告)日：2001-01-16
申请号：US09071100
申请日：1998-05-01
申请人： Li Li , Norma Dimaculangan Alava , Curtis Bobby Motley , David Frederick Swaile , Gerald John Guskey , Thomas Vincent Orr
发明人： Li Li , Norma Dimaculangan Alava , Curtis Bobby Motley , David Frederick Swaile , Gerald John Guskey , Thomas Vincent Orr
IPC分类号： A61K732
CPC分类号： A61K8/42 , A61K8/042 , A61K8/347 , A61K2800/262 , A61K2800/77 , A61Q15/00 , Y10S424/05
摘要： Disclosed are gel deodorant compositions comprising (a) from about 0.001% to about 50% by weight of a deodorant active, fragrance, or combination thereof; (b) from about 0.01% to about 20% by weight of a gellant; (c) from about 5% to about 90% by weight of a polymeric alcohol having at least one free hydroxyl group and also having from about 2 to about 80 alkoxylate radicals wherein the alkoxylate radical contains from about 2 to about 6 carbon atoms; (d) from about 5% to about 89% by weight of a nonpolymeric alcohol having at least two free hydroxyl groups, and also having from about 4 to about 20 carbon atoms, wherein the weight ratio of the polymeric to nonpolymeric alcohol is from about 18:1 to about 1:5; (e) from zero percent to about 10% by weight of glycerin; and (f) from about 0.01% to about 89% by weight of water. Also disclosed is a method of controlling malodor associated with perspiration by topical application of any deodorant composition containing a select combination of triclosan and triclocarban. All of these compositions remain clear or translucent over extended periods of time, and provide little or no skin irritation in addition to improved cosmetic benefits such as dry feel, ease of application, emolliency, fragrance longevity, and no powdery residue.
摘要翻译： 公开了凝胶除臭剂组合物，其包含（a）约0.001重量％至约50重量％的除臭剂活性物质，香料或其组合; （b）约0.01重量％至约20重量％的胶凝剂; （c）约5％至约90％重量的具有至少一个游离羟基并且还具有约2至约80个烷氧基化物基团的聚合醇，其中烷氧基化物基团含有约2至约6个碳原子; （d）约5％至约89％重量的具有至少两个游离羟基的非聚合醇，并且还具有约4-约20个碳原子，其中聚合物与非聚合醇的重量比为约 18：1〜1：5; （e）甘油的0至10重量％; 和（f）约0.01％至约89％重量的水。 还公开了通过局部施用含有三氯生和三氯沙坦的选择性组合的任何除臭剂组合物来控制与出汗相关的恶臭的方法。 所有这些组合物在延长的时间段内保持透明或半透明，并且除了改善的美观效果，例如干燥感觉，易于使用，润肤性，香味长寿命，并且没有粉末残留物之外，提供很少或没有皮肤刺激。
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5.发明授权公开(公告)号：US06183730B2
公开(公告)日：2001-02-06
申请号：US09314795
申请日：1999-05-18
IPC分类号： A61K732
摘要： Disclosed are antiperspirant and deodorant compositions having improved stability, low residue performance and/or improved cosmetics. These compositions comprise select concentrations of cyclohexasiloxane as a volatile silicone material from about 0.1% to about 50% by weight of an antiperspirant active, and from about 0.1% to about 50% by weight of a suspending agent, wherein the compositions are preferably substantially free of cyclotetrasiloxane. The selection of cyclohexasiloxane over other volatile silicone materials provides improved low residue performance, and especially when formulated as an aqueous emulsion it provides improved product stability in the form of extended duration of time within which the emulsion remains clear or nearly so.
摘要翻译： 公开了具有改进的稳定性，低残留性能和/或改进的化妆品的止汗剂和除臭剂组合物。 这些组合物包含作为挥发性有机硅材料的选择浓度的环己硅氧烷，其重量为约0.1％至约50％的止汗活性剂和约0.1％至约50％重量的悬浮剂，其中所述组合物优选基本上不含 的环四硅氧烷。 环己基硅氧烷相对于其它挥发性硅氧烷材料的选择提供了改进的低残留性能，特别是当配制成水性乳液时，其提供改进的产品稳定性，其形式为延长的乳液保持清洁或接近于此的时间。
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公开(公告)号：US5902572A
公开(公告)日：1999-05-11
申请号：US71106
申请日：1998-05-01
申请人： John Paul Luebbe , Li Li , Curtis Bobby Motley , David Frederick Swaile , Gerald John Guskey , Thomas Vincent Orr
发明人： John Paul Luebbe , Li Li , Curtis Bobby Motley , David Frederick Swaile , Gerald John Guskey , Thomas Vincent Orr
CPC分类号： A61K8/361 , A61K8/042 , A61K8/31 , A61Q15/00 , A61K2800/31
摘要： Disclosed are anhydrous gel deodorant compositions comprising from about 0.001% to about 50% by weight of deodorant active, fragrance, or combination thereof, from about 0.01% to about 20% by weight of a gellant; from about 1% to about 50% by weight of a nonpolar volatile solvent having a solubility parameter of less than 8.0 (cal/cm.sup.3).sup.0.5, a vapor pressure of from about 0.01 mm Hg to about 6 mm Hg at 25.degree. C., and a boiling point at 1 atm of less than about 250.degree. C.; from about 1% to about 15% by weight of a polar solvent having a solubility parameter of from 12.5 (cal/cm.sup.3).sup.0.5 to about 25 (cal/cm.sup.3).sup.0.5 and optionally a moderately polar solvent having a solubility parameter of from about 8.0 (cal/cm.sup.3).sup.0.5 to less than 12.5 (cal/cm.sup.3).sup.0.5, preferably 1,2-hexanediol. Other preferred embodiments include those which contain combinations of triclosan and triclocarban for improved deodorant efficacy. These compositions provide improved performance and skin feel characteristics, and are especially effective at providing deodorant application which is milder to the skin, and improved product clarity.
摘要翻译： 公开了无水凝胶除臭剂组合物，其包含约0.001重量％至约50重量％的除臭剂活性物质，香料或其组合，约0.01重量％至约20重量％的胶凝剂; 约1％至约50％重量的溶解度参数小于8.0（cal / cm 3）0.5的非极性挥发性溶剂，25℃下蒸气压为约0.01mmHg至约6mm Hg， 沸点在1atm小于约250℃。 约1％至约15％重量的溶度参数为12.5（cal / cm 3）0.5至约25（cal / cm 3）0.5的极性溶剂和任选的溶度参数为约8.0的中等极性溶剂 （cal / cm 3）0.5至小于12.5（cal / cm 3）0.5，优选1,2-己二醇。 其它优选的实施方案包括含有三氯生和三氯卡班组合以提高除臭功效的实施方案。 这些组合物提供改进的性能和皮肤感觉特性，并且特别有效地提供对皮肤温和的除臭剂应用，并提高产品透明度。
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公开(公告)号：US6013248A
公开(公告)日：2000-01-11
申请号：US71179
申请日：1998-05-01
摘要： The present invention is directed to deodorant compositions, and methods of using such compositions, wherein the compositions comprise from about 0.1% to about 99.9% by weight of a deodorant active, fragrance or combination thereof, and from about 0.1% to about 99.9% by weight of a carrier comprising 1,2-hexanediol. The deodorant composition preferably further comprises a suitable gellant or structurant to provide the desired product form, including a deodorant gel solid stick. The 1,2-hexanediol carrier is a highly effective coupling agent and is milder to the skin when applied topically to the axilla or other areas of the skin as compared to many other polyol-containing deodorant compositions. The present invention also relates to the use of triclosan/triclocarban combinations for improved deodorant efficacy.
摘要翻译： 本发明涉及除臭剂组合物和使用这些组合物的方法，其中组合物包含按重量计约0.1％至约99.9％的除臭剂活性物质，香料或其组合，以及约0.1％至约99.9％ 包含1,2-己二醇的载体的重量。 除臭剂组合物优选还包含合适的胶凝剂或结构剂以提供所需产品形式，包括除臭凝胶固体棒。 与许多其它含多元醇的除臭剂组合物相比，1,2-己二醇载体是高度有效的偶联剂，并且当局部应用于腋窝或皮肤的其它区域时对皮肤温和。 本发明还涉及三氯生/三氯沙坦组合在改善除臭功效方面的用途。
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8.发明授权Antiperspirant gel-solid stick compositions containing select nucleating agents 失效含有选择成核剂的止汗凝胶固体棒组合物
公开(公告)号：US5849276A
公开(公告)日：1998-12-15
申请号：US770392
申请日：1996-12-20
IPC分类号： A61K8/00 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/42 , A61K8/44 , A61K8/58 , A61K8/60 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/894 , A61K8/98 , A61Q15/00 , C08L83/04 , A61K7/32 , A61K7/34 , A61K7/36 , A61K7/38
CPC分类号： A61Q15/00 , A61K8/0229 , A61K8/042 , A61K8/342 , A61K8/365 , A61K8/39 , A61K8/42 , A61K8/44 , A61K8/585 , A61K8/60 , A61K8/86 , A61K8/891 , A61K8/894
摘要： Disclosed are anhydrous antiperspirant compositions comprising from about 0.5% to about 60% by weight of particulate antiperspirant active; from about 1% to about 15% by weight of a solid non-polymeric gellant; from about 10% to about 80% by weight of an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm.sup.3).sup.0.5 ; and from about 0.0001% to about 5.0% by weight of a solid nucleating agent wherein the molar ratio of the solid non-polymeric gellant to the nucleating agent is from about 10:1 to about 1000:1. These antiperspirant compositions provide improved low residue performance and improved antiperspirant efficacy.
摘要翻译： 公开了无水止汗组合物，其包含约0.5重量％至约60重量％的颗粒止汗剂活性物质; 约1重量％至约15重量％的固体非聚合胶凝剂; 约10重量％至约80重量％的平均溶解度参数为约3至约13（cal / cm 3）0.5的无水液体载体; 和约0.0001重量％至约5.0重量％的固体成核剂，其中固体非聚合物胶凝剂与成核剂的摩尔比为约10:1至约1000:1。 这些止汗组合物提供改善的低残留性能和改善的止汗效力。
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9.发明授权
公开(公告)号：US5840286A
公开(公告)日：1998-11-24
申请号：US771088
申请日：1996-12-20
IPC分类号： A61K8/00 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/42 , A61K8/44 , A61K8/58 , A61Q15/00 , C08L83/04 , A61K7/37 , A61K7/00
CPC分类号： A61K8/042 , A61K8/0229 , A61K8/342 , A61K8/365 , A61K8/39 , A61K8/42 , A61K8/585 , A61Q15/00 , A61K2800/31
摘要： Disclosed are methods of making anhydrous antiperspirant gel-solid stick compositions comprising an particulate antiperspirant active; a solid non-polymeric gellant that is substantially free of dibenzylidene alditol, n-acyl amino acid derivatives, organic polymeric gellants, and inorganic thickening agents; and an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm.sup.3).sup.05,wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram.multidot.force to about 5,000 gram.multidot.force, a ratio of an elastic to viscous moduli of from about 0.1 to about 100. The refractive indices of the particulate antiperspirant active, solid non-polymeric gellant, and anhydrous liquid carrier are not matched. The solid non-polymeric gellant is preferably a crystalline material having an average particle size of less than about 1 .mu.m, and/or has an elongated particle morphology having an aspect ratio of greater than about 2. These antiperspirant gel-solid stick compositions made in accordance with the methods herein provide improved low residue performance, efficacy and aesthetics.
摘要翻译： 公开了制备包含颗粒止汗活性物质的无水止汗凝胶 - 固体棒组合物的方法; 基本上不含二亚苄基糖醇，正酰基氨基酸衍生物，有机聚合物胶凝剂和无机增稠剂的固体非聚合物胶凝剂; 和平均溶解度参数为约3至约13（cal / cm 3）05的无水液体载体，其中组合物的可见残留指数为约11至约30L值，产品硬度为约500 克力至约5,000克力，弹性粘度模量的比例为约0.1至约100.颗粒止汗剂活性固体非聚合物胶凝剂和无水液体载体的折射率不匹配。 固体非聚合物胶凝剂优选是平均粒度小于约1μm的结晶材料，和/或具有长宽比大于约2的细长颗粒形态。制备这些止汗凝胶 - 固体棒组合物 根据本文的方法提供了改善的低残留性能，有效性和美观性。
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10.发明授权Low residue antiperspirant gel-solid stick compositions containing select gellants 失效含有选择胶凝剂的低残留止汗凝胶固体棒组合物
公开(公告)号：US5750096A
公开(公告)日：1998-05-12
申请号：US771091
申请日：1996-12-20
申请人： Gerald John Guskey
发明人： Gerald John Guskey
CPC分类号： A61Q15/00 , A61K8/0229 , A61K8/042 , A61K8/365 , A61K8/37 , A61K8/42 , A61K2800/31
摘要： Disclosed are anhydrous antiperspirant gel-solid stick compositions which comprise a particulate antiperspirant active; a solid non-polymeric gellant selected from the group consisting of 12-hydroxystearic acid, esters of 12-hydroxystearic acid, amides of 12-hydroxystearic acid, and combinations thereof, and an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm.sup.3).sup.0.5, wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram.force to about 5,000 gram.force, a ratio of an elastic to viscous moduli of from about 0.1 to about 100. The refractive indices of the particulate antiperspirant active, solid non-polymeric gellant, and anhydrous liquid carrier are not matched. The solid non-polymeric gellant is preferably a crystalline material having an average particle size of less than about 1 .mu.m, and/or having an elongated particle morphology having an aspect ratio of greater than about 2. These antiperspirant gel-solid stick compositions provide improved low residue performance, efficacy and aesthetics.
摘要翻译： 公开了包含颗粒止汗活性物质的无水止汗凝胶 - 固体棒组合物; 选自12-羟基硬脂酸，12-羟基硬脂酸的酯，12-羟基硬脂酸的酰胺及其组合的固体非聚合物胶凝剂，以及平均溶解度参数为约3至 约13（cal / cm 3）0.5，其中组合物具有约11至约30L值的可见残留指数，约500克力至约5,000克力的产品硬度，弹性 粘度模量为约0.1至约100.颗粒止汗剂活性固体非聚合物胶凝剂和无水液体载体的折射率不匹配。 固体非聚合物胶凝剂优选是平均粒度小于约1μm的结晶材料和/或具有长宽比大于约2的细长颗粒形态。这些止汗凝胶 - 固体棒组合物提供 改善了低残留性能，有效性和美观性。
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