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公开(公告)号：US07235669B2
公开(公告)日：2007-06-26
申请号：US11354769
申请日：2006-02-15
申请人： Gerhard Hoefle , Hans Reichenbach , Klaus Gerth , Ingo Hardt , Florenz Sasse , Heinrich Steinmetz
发明人： Gerhard Hoefle , Hans Reichenbach , Klaus Gerth , Ingo Hardt , Florenz Sasse , Heinrich Steinmetz
IPC分类号： C07D417/06
CPC分类号： C07D413/06 , C07D277/24 , C07D417/06 , C07D493/04
摘要： The invention concerns compounds which can be obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2.
摘要翻译： 本发明涉及通过发酵DSM 6773，特别是埃坡霉素A1，A2，A8，A9，B10，C1，C2，C3，C4，C5，C6，C7，C8，C9，D1，D2，D5，G1 ，G2，H1，H2，I1，I2，I3，I4，I5，I6和K以及反式埃坡霉素C1和C2。
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公开(公告)号：US06624310B1
公开(公告)日：2003-09-23
申请号：US09719932
申请日：2001-03-21
申请人： Gerhard Hoefle , Hans Reichenbach , Klaus Gerth , Ingo Hardt , Florenz Sasse , Heinrich Steinmetz
发明人： Gerhard Hoefle , Hans Reichenbach , Klaus Gerth , Ingo Hardt , Florenz Sasse , Heinrich Steinmetz
IPC分类号： C07D49304
CPC分类号： C07D413/06 , C07D277/24 , C07D417/06 , C07D493/04
摘要： The invention relates to compounds which are obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2.
摘要翻译： 本发明涉及通过发酵DSM6773，特别是埃坡霉素A1，A2，A8，A9，B10，C1，C2，C3，C4，C5，C6，C7，C8，C9，D1，D2，D5，G1 ，G2，H1，H2，I1，I2，I3，I4，I5，I6和K以及反式埃坡霉素C1和C2。
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公开(公告)号：US5604249A
公开(公告)日：1997-02-18
申请号：US487382
申请日：1995-06-07
申请人： Gerhard H ofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
发明人： Gerhard H ofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
IPC分类号： A01N43/78 , A01N63/02 , C07D417/14 , G07D417/14
CPC分类号： A01N43/78 , A01N63/02 , C07D417/14
摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.
摘要翻译： 本发明涉及以下通式I的化合物，其特别是称为噻唑的式Ia化合物（Ia）其药学上可接受的酸加成盐，其制备方法 以及可用于作物保护的治疗组合物和组合物。
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公开(公告)号：US5610038A
公开(公告)日：1997-03-11
申请号：US487385
申请日：1995-06-07
申请人： Gerhard Hofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
发明人： Gerhard Hofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
IPC分类号： A01N43/78 , A01N63/02 , C07D417/14 , C12P17/16
CPC分类号： A01N43/78 , A01N63/02 , C07D417/14
摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.
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公开(公告)号：US5622979A
公开(公告)日：1997-04-22
申请号：US487384
申请日：1995-06-07
申请人： Gerhard H ofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
发明人： Gerhard H ofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
IPC分类号： A01N43/78 , A01N63/02 , C07D417/14
CPC分类号： A01N43/78 , A01N63/02 , C07D417/14
摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.
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公开(公告)号：US07759375B2
公开(公告)日：2010-07-20
申请号：US12434078
申请日：2009-05-01
IPC分类号： A61K31/427 , C07D277/24
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
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公开(公告)号：US20110136185A1
公开(公告)日：2011-06-09
申请号：US12961447
申请日：2010-12-06
IPC分类号： C12P17/16 , C07D277/30
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
摘要翻译： 本发明涉及埃坡霉素C，D，E和F，其制备及其用于生产用于植物保护的治疗组合物和组合物的用途。
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公开(公告)号：US20090270466A1
公开(公告)日：2009-10-29
申请号：US12434078
申请日：2009-05-01
IPC分类号： A61K31/427 , C07D415/00
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
摘要翻译： 本发明涉及埃坡霉素C，D，E和F，其制备及其用于生产用于植物保护的治疗组合物和组合物的用途。
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公开(公告)号：US08076490B2
公开(公告)日：2011-12-13
申请号：US12961447
申请日：2010-12-06
IPC分类号： C07D277/22
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
摘要翻译： 本发明涉及埃坡霉素C，D，E和F，其制备及其用于生产用于植物保护的治疗组合物和组合物的用途。
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公开(公告)号：US20050090535A1
公开(公告)日：2005-04-28
申请号：US10988328
申请日：2004-11-12
IPC分类号： A01N43/78 , A01N43/90 , A01N63/02 , A61K31/425 , A61K31/427 , A61P35/00 , C07D417/06 , C07D493/04 , C12P1/04 , C12P17/08 , C12P17/16 , C12P17/18 , C12R1/01 , C07D417/02
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
摘要翻译： 本发明涉及埃坡霉素C，D，E和F，它们的制备及其用于生产用于植物保护的治疗组合物和组合物的用途。
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