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公开(公告)号：US5610038A
公开(公告)日：1997-03-11
申请号：US487385
申请日：1995-06-07
申请人： Gerhard Hofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
发明人： Gerhard Hofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
IPC分类号： A01N43/78 , A01N63/02 , C07D417/14 , C12P17/16
CPC分类号： A01N43/78 , A01N63/02 , C07D417/14
摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.
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公开(公告)号：US5096922A
公开(公告)日：1992-03-17
申请号：US512963
申请日：1990-04-23
申请人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
发明人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
IPC分类号： C07D323/00 , A61K31/357 , A61K31/365 , A61P31/04 , A61P31/12 , C07D493/22 , C07H17/08 , C12P17/18 , C12P19/62 , C12R1/01
CPC分类号： C07D493/22 , C07H17/08 , C12P19/623
摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration;R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium cellulosum and are effective antibiotics.
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公开(公告)号：US4987072A
公开(公告)日：1991-01-22
申请号：US907446
申请日：1986-09-11
申请人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
发明人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
IPC分类号： C07D323/00 , A61K31/357 , A61K31/365 , A61P31/04 , A61P31/12 , C07D493/22 , C07H17/08 , C12P17/18 , C12P19/62 , C12R1/01
CPC分类号： C07D493/22 , C07H17/08 , C12P19/623
摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or .beta.-glucopyranosyloxy, and to the hydrates and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium celulosum and are effective antiobiotics.
摘要翻译： 本发明涉及式（I）的环状抗生素，其中前缀R表示相邻碳原子上的取代基为R构型; 前缀S表示相邻碳原子上的取代基为S构型; R1是氢或羟基，R2是羟基或β-吡喃葡萄糖基氧基，以及其水合物和盐，特别是药学上可接受的盐。 式Ⅰ化合物是通过使用种类Sorangium celulosum的菌株So ce 12（NCIB 12134）进行发酵而制备的，并且是有效的抗生素。
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公开(公告)号：US5023184A
公开(公告)日：1991-06-11
申请号：US85438
申请日：1987-08-13
申请人： Hans Reichenbach , Klaus Gerth , Herbert Irschik , Brigitte Kunze , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Rolf Jansen , Wolfram Trowitzsch-Kienast , Heinrich Steinmetz
发明人： Hans Reichenbach , Klaus Gerth , Herbert Irschik , Brigitte Kunze , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Rolf Jansen , Wolfram Trowitzsch-Kienast , Heinrich Steinmetz
IPC分类号： A61K31/495 , A61P31/04 , A61P35/00 , C07D471/18 , C12P17/18 , C12R1/01
CPC分类号： C07D471/18 , C12P17/182 , C12R1/01
摘要： The invention relates to novel polycyclic alkaloids of formula ##STR1## in which R.sup.1 represents hydrogen or hydroxy, R.sup.2 represents hydrogen or acyl and A and B, independently of one another, each represents C.dbd.O or C--OH, and wherein the dashed line represents a C.dbd.C double bond at the position of the middle bond when A or B represents C.dbd.O, or at the position of the two outer bonds when A or B represents C--OH, a process for the manufacture of these compounds by fermentation of a novel microorganism of the species Myxococcus xanthus, the novel microorganism itself, pharmacetical preparations that contain the novel compounds, and the use of the novel compounds as antibiotics and as tumour-inhibiting agents and for the manufacture of pharmaceutical preparations.
摘要翻译： 本发明涉及式（I）的新型多环生物碱，其中R 1表示氢或羟基，R 2表示氢或酰基，A和B彼此独立地表示C = O或C-OH，并且其中 当A或B表示C = O时，虚线表示中间键的位置处的C = C双键，或者当A或B表示C-OH时，在两个外键的位置处，制造 这些化合物通过发酵黄连球菌的新型微生物，新型微生物本身，含有新化合物的药物制剂，以及使用新化合物作为抗生素和作为肿瘤抑制剂和用于制备药物制剂。
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公开(公告)号：US5093358A
公开(公告)日：1992-03-03
申请号：US563776
申请日：1990-08-07
CPC分类号： A01N43/90
摘要： Compounds of the formula I ##STR1## in which either R is methyl and there is a double bond in the 9,10-position, or in which R is hydrogen and there is a single bond in the 9,10-position, are highly active against Acarina which damage plants.
摘要翻译： 其中R为甲基并且在9,10-位具有双键或其中R为氢且在9,10-位具有单键的式I的化合物（I） ，对于损害植物的Acarina具有高度的活性。
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公开(公告)号：US4954517A
公开(公告)日：1990-09-04
申请号：US405382
申请日：1989-09-08
IPC分类号： A01N43/90 , C07D493/08 , C07D493/18 , C07H19/01
CPC分类号： C07D493/08 , A01N43/90 , C07H19/01
摘要： A macrocyclic compound of the formula I, ##STR1## in which the substituents have the following meaning: X is hydrogen or methyl, Y is hydrogen, --CHO, --COCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 NH.sub.2, benzyl, methyl or a silyl group, and A--B--C is the following C.sub.3 -chain members: ##STR2## in which R.sub.1, R.sub.2 and R.sub.3, independently of one another, are hydrogen, methyl, --CHO, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 NH.sub.2 or a silyl group, and R.sub.4 and R.sub.5 are hydrogen, halogen or --COO(C.sub.1 --C.sub.3) alkyl, is suitable for controlling and preventing plant diseases. A compound of this type can be employed in a customary manner in the form of plant-protecting agents formulated with carrier substances and extenders.
摘要翻译： 式I的大环化合物，其中取代基具有以下含义：X是氢或甲基，Y是氢，-CHO，-COCH 3，-COCH 2 OCH 3，-COCH 2 OCH 3，-COCH 2 NH 2，苄基， 甲基或甲硅烷基，ABC是以下C3链成员：其中R1，R2和R3彼此独立地为氢，甲基，-CHO，-COCH2OCH3，-COCH2OCH3， - COCH2NH2或甲硅烷基，R4和R5是氢，卤素或-COO（C1-C3）烷基，适用于防治植物病害。 这种类型的化合物可以以常规方式以用载体物质和增量剂配制的植物保护剂的形式使用。
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公开(公告)号：US4997820A
公开(公告)日：1991-03-05
申请号：US405376
申请日：1989-09-08
摘要： Novel macrocyclic compounds of the formual I ##STR1## where the dotted line in the 9,10-position is a saturated bond or a double bond, alternatively, and R is hydrogen, methyl or certain acyl radicals, and R.sub.o is hydrogen, halogen, azido, thiol, hydroxyl or --OY, where Y is, among other radicals, an ether radical, a silyl group, a sulfonyl group, a sugar radical or a (thiol)acyl radical, and R being methyl if there is a double bond in the 9,10-position, have microbicidal properties for the control of phytopathogenic microorganisms. They can be employed in the customary formulation for the control of plant disease.
摘要翻译： 其中9,10位的虚线是饱和键或双键的式I（I）的新型大环化合物，或者R是氢，甲基或某些酰基，Ro是氢 卤素，叠氮基，硫醇，羟基或-OY，其中Y是醚基，甲硅烷基，磺酰基，糖基或（硫醇）酰基等基团，R是甲基，如果有 在9,10位的双键具有控制植物病原微生物的杀菌性。 它们可以用于控制植物病害的习惯制剂。
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公开(公告)号：US4940804A
公开(公告)日：1990-07-10
申请号：US405379
申请日：1989-09-08
IPC分类号： C07D493/08 , A01N43/90 , C07H19/01
摘要： Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
摘要翻译： 衍生的式I（I）的大环化合物其中R是氢，甲基或某些酰基，9,10-位的虚线是饱和键，或者在R是甲基的情况下也是 双键，X是酮基，或取代或未取代的肟，腙或缩氨基脲代表用于防治植物病害的有效杀微生物剂。 它们可以作为农药的常规制剂使用。
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公开(公告)号：US5026878A
公开(公告)日：1991-06-25
申请号：US602825
申请日：1990-10-25
IPC分类号： C07D493/08 , A01N43/90 , C07H19/01
摘要： Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
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公开(公告)号：US4987149A
公开(公告)日：1991-01-22
申请号：US485120
申请日：1990-02-23
IPC分类号： C07D493/08 , A01N43/90 , C07H19/01
摘要： Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
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