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公开(公告)号:US07482605B2
公开(公告)日:2009-01-27
申请号:US10853850
申请日:2004-05-25
申请人: Gerhard Kraft , Ulrich Weber , Sebastian Kraft , Stephan Kraft
发明人: Gerhard Kraft , Ulrich Weber , Sebastian Kraft , Stephan Kraft
CPC分类号: G21K1/046 , A61N5/1042 , A61N2005/1087 , A61N2005/1095 , G21K1/04 , G21K1/10
摘要: An energy filter device for beams which are used in the course of ion beam therapy, wherein at least one passive modulator is provided. The modulator can comprise a scattering film for the beams and a collimator with an opening for controlling the beams, or a magnetic filter and an absorber, or a nonlinear filter and an apparatus for clipping the intensity of individual energy levels of the beams.
摘要翻译: 一种用于在离子束治疗过程中使用的光束的能量过滤装置,其中提供至少一个无源调制器。 调制器可以包括用于光束的散射膜和具有用于控制光束的开口的准直器,或磁性滤光器和吸收体,或非线性滤光器以及用于限制光束的各个能级的强度的装置。
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公开(公告)号:US20050029471A1
公开(公告)日:2005-02-10
申请号:US10853850
申请日:2004-05-25
申请人: Gerhard Kraft , Ulrich Weber , Sebastian Kraft , Stephan Kraft
发明人: Gerhard Kraft , Ulrich Weber , Sebastian Kraft , Stephan Kraft
CPC分类号: G21K1/046 , A61N5/1042 , A61N2005/1087 , A61N2005/1095 , G21K1/04 , G21K1/10
摘要: An energy filter device for beams which are used in the course of ion beam therapy, wherein at least one passive modulator is provided. The modulator comprises a scattering film for the beams and a collimator with an opening for controlling the beams.
摘要翻译: 一种用于在离子束治疗过程中使用的光束的能量过滤装置,其中提供至少一个无源调制器。 调制器包括用于光束的散射膜和具有用于控制光束的开口的准直器。
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公开(公告)号:US06683318B1
公开(公告)日:2004-01-27
申请号:US09786698
申请日:2001-07-10
申请人: Thomas Haberer , Michael Kraemer , Gerhard Kraft , Wilma Kraft-Weyrather , Dieter Schardt , Michael Scholz , Ulrich Weber , Aleksiy Dolinski , Hartmut Eickhoff , Bernhard Franczak , Udo Krause , Juergen Klabunde , Ludwig Dahl , Marius Pavlovic , Ulrich Ratzinger , Bernhard Schlitt , Joerg Pawelke , Rainer Hinz , Wolfgang Enghardt
发明人: Thomas Haberer , Michael Kraemer , Gerhard Kraft , Wilma Kraft-Weyrather , Dieter Schardt , Michael Scholz , Ulrich Weber , Aleksiy Dolinski , Hartmut Eickhoff , Bernhard Franczak , Udo Krause , Juergen Klabunde , Ludwig Dahl , Marius Pavlovic , Ulrich Ratzinger , Bernhard Schlitt , Joerg Pawelke , Rainer Hinz , Wolfgang Enghardt
IPC分类号: A61N501
CPC分类号: A61N5/1079 , A61N5/10 , A61N5/1043 , A61N5/1081 , A61N2005/1052 , A61N2005/1087 , G21K5/10
摘要: An ion beam therapy system and method for operating the system includes a source of ions (300), an accelerator system (400) and an ion beam transport system (60) for directing an ion beam to a plurality of treatment stations (100) to treat patients. The ion beam transport system (60) includes a gantry (8) carrying a vertical deflection system (45) and horizontal deflection system (55) positioned upstream from a last bending magnet (65) so as to provide a parallel scanning mode by an edge focusing effect.
摘要翻译: 用于操作该系统的离子束治疗系统和方法包括离子源(300),加速器系统(400)和离子束传输系统(60),用于将离子束引导到多个处理站(100)至 治疗病人。 离子束输送系统(60)包括承载垂直偏转系统(45)的台架(8)和位于最后弯曲磁体(65)上游的水平偏转系统(55),以便通过边缘 聚焦效果。
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公开(公告)号:US06710362B2
公开(公告)日:2004-03-23
申请号:US10239685
申请日:2003-01-08
申请人: Gerhard Kraft , Ulrich Weber
发明人: Gerhard Kraft , Ulrich Weber
IPC分类号: A61N500
CPC分类号: A61N5/1049 , A61N5/1043 , A61N5/1067 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095
摘要: The invention relates to an apparatus and a method for irradiating tumor tissue (3) of a patient (10) by means of an ion beam (2). For that purpose, the apparatus has a deflecting device (1) for the ion beam (2) for slice-wise and area-wise scanning of the tumor tissue (3) and an ion beam energy control device for slice-wise and depth-wise scanning of the ion beam (2). An electromechanically driven ion-braking device (11, 12) is provided as a depth-wise scanning adaptation apparatus (5) for adapting the range of the ion beam (2) and has faster depth-wise adaptation than the energy control device of an accelerator. The movement of a patient is monitored by means of a movement detection device (7) for detecting a temporal and positional change in the location of the tumor tissue (3) in a treatment space (8). A control device controls the deflecting device (1) and the depth-wise adaptation apparatus (5) for adjusting the ion beam direction and ion beam range, respectively, when scanning the tumor tissue (3) in the course of temporal and positional change in the location of the tumor tissue (3) in the treatment space (8).
摘要翻译: 本发明涉及一种通过离子束(2)照射患者(10)的肿瘤组织(3)的装置和方法。 为此,该装置具有用于离子束(2)的偏转装置(1),用于对肿瘤组织(3)进行切片和区域扫描,以及用于切片和深度扫描的离子束能量控制装置, 扫描离子束(2)。 提供一种机电驱动的离子制动装置(11,12)作为深度扫描适应装置(5),用于使离子束(2)的范围适应,并具有比其能量控制装置更深的深度适应性 加速器。 通过移动检测装置(7)来监视患者的运动,用于检测治疗空间(8)中肿瘤组织(3)的位置的时间和位置变化。 当在时间和位置变化的过程中扫描肿瘤组织(3)时,控制装置控制偏转装置(1)和深度适应装置(5),用于分别调节离子束方向和离子束范围 肿瘤组织(3)在治疗空间(8)中的位置。
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公开(公告)号:US06891177B1
公开(公告)日:2005-05-10
申请号:US09890897
申请日:2000-02-11
申请人: Gerhard Kraft , Ulrich Weber
发明人: Gerhard Kraft , Ulrich Weber
IPC分类号: A61N5/10 , G21K1/04 , G21K3/00 , G21K5/00 , G21K5/04 , G21K1/00 , G21K1/02 , H01J5/18 , H01J29/46
CPC分类号: G21K1/10 , A61N5/1042 , A61N5/1043 , A61N2005/1087 , A61N2005/1095 , G21K1/04 , G21K1/046 , G21K5/04
摘要: The invention relates to an ion beam scanning system having an ion source device, an ion acceleration system and an ion beam guidance system comprising an ion beam outlet window for a converging centered ion beam, and a mechanical alignment system for the target volume to be scanned. For that purpose, the ion acceleration system can be set to an acceleration of the ions required to obtain a maximum depth of penetration. The scanning system also has energy absorption means arranged in the path of the ion beam between the target volume and the ion beam outlet window transverse to the center of the ion beam. The energy absorption means can be displaced transverse to the center of the ion beam in order to vary the energy of the ion beam, so enabling, in the target volume, depth modulation of the ion beam, which is effected by means of a linear motor and the transverse displacement of the energy absorption means, with depth-staggered scanning of volume elements of the target volume in rapid succession. The invention relates also to a method of ion beam scanning and a method of operating an ion beam scanning system using a gantry system.
摘要翻译: 本发明涉及一种具有离子源装置,离子加速系统和离子束引导系统的离子束扫描系统,该离子束引导系统包括用于会聚中心离子束的离子束出口窗口和用于待扫描的目标体积的机械对准系统 。 为此,可以将离子加速系统设定为获得最大穿透深度所需离子的加速度。 扫描系统还具有布置在离子束的路径中的能量吸收装置,该离子束在目标体积和垂直于离子束中心的离子束出射窗口之间。 能量吸收装置可以横向于离子束的中心位移,以便改变离子束的能量,从而使目标体积中的离子束的深度调制能够通过线性电动机 以及能量吸收装置的横向位移,其中快速连续地对目标体积的体积元素进行深度交错的扫描。 本发明还涉及离子束扫描的方法和使用龙门架系统操作离子束扫描系统的方法。
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公开(公告)号:US08405050B2
公开(公告)日:2013-03-26
申请号:US12678562
申请日:2008-09-25
申请人: Christoph Bert , Gerhard Kraft , Eike Rietzel , Alexander Gemmel
发明人: Christoph Bert , Gerhard Kraft , Eike Rietzel , Alexander Gemmel
IPC分类号: G01J1/00
CPC分类号: A61N5/103 , A61N5/1037 , A61N5/1043 , A61N5/1067 , A61N2005/1061 , A61N2005/1072 , A61N2005/1087
摘要: A method of determining an actual, especially an actual effective, radiation dose distribution of a moving target volume includes detecting first and further positions of volume elements of the target volume in a first and at least one further motional state of the moving target volume, determining transformation parameters by transformation of the first positions into the further positions, irradiating the moving target volume in accordance with an irradiation plan which comprises a plurality of raster points to be irradiated, wherein during the irradiation of a raster point it is detected which of the motional states is occupied by the moving target volume, assigning raster points to subirradiation plans and determining the actual effective dose for each of the plurality of volume elements, in each case from contributions from the raster points of the subirradiation plans using the transformation parameters. Calculation and application of correction parameters which compensate for changes, caused by movement, to the position of the Bragg maximum and to the biologically effective dose applied.
摘要翻译: 确定移动目标体积的实际的,特别是实际有效的辐射剂量分布的方法包括:检测目标体积的体积元素在移动目标体积的第一和至少一个另外的运动状态中的第一和另外的位置,确定 通过将第一位置变换为其他位置,根据包括要照射的多个光栅点的照射方案照射移动目标体积,在光栅点的照射期间检测哪个运动目标体积, 状态由移动目标体积占据,将光栅点分配给子辐射计划,并且在每个情况下确定多个体积元素中的每一个的实际有效剂量,这取决于来自使用变换参数的子照射计划的光栅点的贡献。 校正参数的计算和应用,补偿由运动引起的布拉格最大位置和施加的生物有效剂量的变化。
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公开(公告)号:US20120025076A1
公开(公告)日:2012-02-02
申请号:US13262949
申请日:2010-04-06
申请人: Gerhard Kraft
发明人: Gerhard Kraft
IPC分类号: G01N23/00
CPC分类号: G01T1/29 , A61N5/1049 , A61N2005/1052 , A61N2005/1087 , G01T1/169
摘要: A detector device detects the penetration depth of a particle beam applied to a target volume. The detector device includes a first detection device and a second detection device. The second detection device is configured to detect photons that are formed in the target volume and is disposed behind the first detection device with respect to a direction of the particle beam.
摘要翻译: 检测器装置检测施加到目标体积的粒子束的穿透深度。 检测器装置包括第一检测装置和第二检测装置。 第二检测装置被配置为检测形成在目标体积中并相对于粒子束的方向设置在第一检测装置后面的光子。
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公开(公告)号:US20100301235A1
公开(公告)日:2010-12-02
申请号:US12678562
申请日:2008-09-25
申请人: Christoph Bert , Gerhard Kraft , Eike Rietzel , Alexander Gemmel
发明人: Christoph Bert , Gerhard Kraft , Eike Rietzel , Alexander Gemmel
IPC分类号: A61N5/10
CPC分类号: A61N5/103 , A61N5/1037 , A61N5/1043 , A61N5/1067 , A61N2005/1061 , A61N2005/1072 , A61N2005/1087
摘要: A method of determining an actual, especially an actual effective, radiation dose distribution of a moving target volume includes detecting first and further positions of volume elements of the target volume in a first and at least one further motional state of the moving target volume, determining transformation parameters by transformation of the first positions into the further positions, irradiating the moving target volume in accordance with an irradiation plan which comprises a plurality of raster points to be irradiated, wherein during the irradiation of a raster point it is detected which of the motional states is occupied by the moving target volume, assigning raster points to subirradiation plans and determining the actual effective dose for each of the plurality of volume elements, in each case from contributions from the raster points of the subirradiation plans using the transformation parameters. Calculation and application of correction parameters which compensate for changes, caused by movement, to the position of the Bragg maximum and to the biologically effective dose applied.
摘要翻译: 确定移动目标体积的实际的,特别是实际有效的辐射剂量分布的方法包括:检测目标体积的体积元素在移动目标体积的第一和至少一个另外的运动状态中的第一和另外的位置,确定 通过将第一位置变换为其他位置,根据包括要照射的多个光栅点的照射方案照射移动目标体积,在光栅点的照射期间检测哪个运动目标体积, 状态由移动目标体积占据,将光栅点分配给子辐射计划,并且在每个情况下确定多个体积元素中的每一个的实际有效剂量,这取决于来自使用变换参数的子照射计划的光栅点的贡献。 校正参数的计算和应用,补偿由运动引起的布拉格最大位置和施加的生物有效剂量的变化。
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公开(公告)号:US08426814B2
公开(公告)日:2013-04-23
申请号:US13262949
申请日:2010-04-06
申请人: Gerhard Kraft
发明人: Gerhard Kraft
IPC分类号: G01J1/00
CPC分类号: G01T1/29 , A61N5/1049 , A61N2005/1052 , A61N2005/1087 , G01T1/169
摘要: A detector device detects the penetration depth of a particle beam applied to a target volume. The detector device includes a first detection device and a second detection device. The second detection device is configured to detect photons that are formed in the target volume and is disposed behind the first detection device with respect to a direction of the particle beam.
摘要翻译: 检测器装置检测施加到目标体积的粒子束的穿透深度。 检测器装置包括第一检测装置和第二检测装置。 第二检测装置被配置为检测形成在目标体积中并相对于粒子束的方向设置在第一检测装置后面的光子。
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公开(公告)号:US20130092839A1
公开(公告)日:2013-04-18
申请号:US13805676
申请日:2011-05-26
申请人: Gerhard Kraft , Nami Saito , Dieter Schardt
发明人: Gerhard Kraft , Nami Saito , Dieter Schardt
CPC分类号: G21K5/10 , A61B6/00 , A61N5/1043 , A61N5/1049 , A61N5/1077 , A61N2005/1054 , A61N2005/1087 , G21K5/02 , G21K5/04
摘要: A particle beam generating device includes at least one accelerator unit for generating a particle beam and at least one emission unit for the output of the at least one particle beam onto a workpiece. The device is configured to release at least two particle beams including hadronic particles with at least one of a different mass or a different charge.
摘要翻译: 粒子束产生装置包括用于产生粒子束的至少一个加速器单元和用于将至少一个粒子束输出到工件上的至少一个发射单元。 该装置被配置为释放至少两个粒子束,包括具有不同质量或不同电荷中的至少一种的强子粒子。
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