公开(公告)号：US20140121261A1

公开(公告)日：2014-05-01

申请号：US13829594

申请日：2013-03-14

Applicant: GERON CORPORATION

Inventor： Sergei M. GRYAZNOV ,  Daria Zielinska ,  Ronald A. Pruzan ,  Jeffrey N. Lindquist

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/31 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2310/345 ,  C12N2310/3515 ,  C12N2310/3517 ,  C12N2320/10 ,  C12N2320/30

Abstract: Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same.

Abstract translation: 本文提供的是可以有效预防或减少c-myc蛋白表达以及降低体外和哺乳动物细胞增殖性疾病体内模型中细胞增殖的总体速率的反义寡核苷酸以及使用该方法。

公开(公告)号：US20240300992A1

公开(公告)日：2024-09-12

申请号：US18490328

申请日：2023-10-19

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12

CPC classification number: C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

公开(公告)号：US20240034748A1

公开(公告)日：2024-02-01

申请号：US18074179

申请日：2022-12-02

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/16 ,  C07H19/06 ,  C07H19/12 ,  C07H19/10

CPC classification number: C07H19/16 ,  C07H19/06 ,  C07H19/12 ,  C07H19/10

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

公开(公告)号：US20200377543A1

公开(公告)日：2020-12-03

申请号：US16944903

申请日：2020-07-31

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/16 ,  C07H19/12 ,  C07H19/10 ,  C07H19/06

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

公开(公告)号：US09771581B2

公开(公告)日：2017-09-26

申请号：US14957463

申请日：2015-12-02

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Daria Zielinska ,  Ronald A. Pruzan ,  Jeffrey N. Lindquist

IPC: C07H21/04 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/31 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2310/345 ,  C12N2310/3515 ,  C12N2310/3517 ,  C12N2320/10 ,  C12N2320/30

Abstract: Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same.

公开(公告)号：US20160362440A1

公开(公告)日：2016-12-15

申请号：US15155781

申请日：2016-05-16

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/16 ,  C07H19/06

CPC classification number: C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

Abstract translation: 描述了正交保护的3'-氨基核苷单体及其合成的有效方法。 该方法在未保护的核苷碱基存在下采用3'-氨基的选择性保护。

公开(公告)号：US09365606B2

公开(公告)日：2016-06-14

申请号：US14276381

申请日：2014-05-13

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/12

CPC classification number: C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

Abstract translation: 描述了正交保护的3'-氨基核苷单体及其合成的有效方法。 该方法在未保护的核苷碱基存在下采用3'-氨基的选择性保护。

公开(公告)号：US10738073B2

公开(公告)日：2020-08-11

申请号：US16024221

申请日：2018-06-29

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/16 ,  C07H19/06 ,  C07H19/12 ,  C07H19/10

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

公开(公告)号：US10035815B2

公开(公告)日：2018-07-31

申请号：US15155781

申请日：2016-05-16

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/06 ,  C07H19/16 ,  C07H19/12 ,  C07H19/10

CPC classification number: C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

公开(公告)号：US20230089101A1

公开(公告)日：2023-03-23

申请号：US17824377

申请日：2022-05-25

Applicant: Geron Corporation

Inventor： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC: C07H19/16 ,  C07H19/06 ,  C07H19/12 ,  C07H19/10

Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.