公开(公告)号：US08208997B2

公开(公告)日：2012-06-26

申请号：US10592024

申请日：2005-04-18

申请人： Gert Nilsson ,  Folke Sjöberg

发明人： Gert Nilsson ,  Folke Sjöberg

IPC分类号： A61B5/02

CPC分类号： A61B5/0261

摘要： This invention relates to the non-invasive determination of the degree of vasoactivity in the microcirculation in a tissue caused by a drug, disease, injury normal or pathological regulation. More specifically, the invention relates to a method of determining the influence on microcirculation in living tissue from an irritative agent, drugs, disease, injuries normal or pathological regulation including, illuminating a tissue surface with polarized light, collecting the backscattered light through a polarizing filter, detecting the backscattered and polarized light by a photo-sensitive array, transferring the collected information in digital form to a computing device, separating the collected information into at least two data matrixes, each representing a specific wavelength range and generating an output data matrix by processing corresponding values in at least two data matrixes by an algorithm, wherein each value in said output data matrix represents the amount of influence on the microcirculation in a source point of the tissue. Thereby a representation of the tissue microcirculation is obtained.

摘要翻译： 本发明涉及由药物，疾病，损伤正常或病理调节引起的组织微循环中血管活性程度的非侵入性测定。 更具体地说，本发明涉及一种确定活体组织中微循环对刺激剂，药物，疾病，损伤正常或病理调节的影响的方法，包括用偏振光照射组织表面，通过偏振滤光片收集反向散射光 通过光敏阵列检测反向散射和偏振光，将收集的数字形式的信息传送到计算设备，将收集的信息分离成至少两个数据矩阵，每个数据矩阵表示特定波长范围，并通过以下方式生成输出数据矩阵： 通过算法处理至少两个数据矩阵中的相应值，其中所述输出数据矩阵中的每个值表示对组织的源点中的微循环的影响量。 从而获得组织微循环的表示。

公开(公告)号：US4590948A

公开(公告)日：1986-05-27

申请号：US689489

申请日：1985-01-07

申请人： Gert Nilsson

发明人： Gert Nilsson

IPC分类号： A61B5/00 ,  A61B5/026 ,  A61B5/02

CPC分类号： A61B5/0261

摘要： In a method and an apparatus for measuring the superficial blood flow in tissue, a section of the tissue is irradiated with monochromatic light from a laser source. Light scattered by moving blood cells and adjacent stationary structure within a part of the irradiated section is collected and passed to a photo-detector arrangement, which produces an output signal containing fluctuating signal components, a Doppler signal, deriving from interference between light components having differing frequencies due to having been scattered by moving blood cells and thereby subject to frequency shifts. The Doppler signal contains information concerning the number of blood cells present and the velocity at which they move. By means of a signal processor, there is derived from the Doppler signal a signal which is linearly related to the blood flow expressed as the product of the number of blood cells and their average velocity of movement, and a signal which is linearly related to the number of blood cells present.

摘要翻译： 在用于测量组织中浅表血流的方法和装置中，用来自激光源的单色光照射组织的一部分。 收集通过在照射部分的一部分内通过移动血细胞和相邻固定结构而散射的光，该光检测器装置产生包含波动信号分量的输出信号，多普勒信号，其来源于具有不同 由于通过移动血细胞而被散射并因此经受频移。 多普勒信号包含有关存在的血细胞数和移动速度的信息。 借助于信号处理器，从多普勒信号得出与血流线性相关的信号，其表示为血细胞数和它们的平均移动速度的乘积，和与 存在血细胞数。

公开(公告)号：US06629973B1

公开(公告)日：2003-10-07

申请号：US09889449

申请日：2001-07-16

申请人： Karin Wårdell ,  Ola Eriksson ,  Gert Nilsson

发明人： Karin Wårdell ,  Ola Eriksson ,  Gert Nilsson

IPC分类号： A61B1818

CPC分类号： A61B18/148 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00761 ,  A61B2018/00791

摘要： The present invention relates to an apparatus for destroying a predetermined defined volume (10) in a tissue, such as generating controlled coagulation, so-called lesion, in the brain. More particularly, the apparatus comprises a main unit (1) for transmitting a tissue-destroying medium comprising a control unit (3) for controlling the medium transmission, and a transferring means (4), such as an electrode, which is connected to said main unit and adapted to be inserted into the predetermined volume for transferring the transmitted medium to the volume. The apparatus according to the invention is characterised in that it further comprises a measuring means (5-8) for measuring at least one optical characteristic of the predetermined volume, the optical characteristic varying with the size of the destroyed volume, the measuring means being connected to said control unit for controlling the supply of the tissue-destroying medium on the basis of the measured optical characteristic.

摘要翻译： 本发明涉及一种用于在组织中破坏预定的限定体积（10）的设备，例如在脑中产生受控制的凝血，所谓的病变。 更具体地说，该装置包括用于传送组织破坏介质的主单元（1），该组件破坏介质包括用于控制介质传输的控制单元（3），和一个与所述介质传输连接的传送装置（如电极） 并且适于插入到预定的容积中以将传送的介质传送到体积。 根据本发明的装置的特征在于，它还包括用于测量预定体积的至少一个光学特性的测量装置（5-8），所述光学特性随着破坏的体积的大小而变化，所述测量装置被连接 到所述控制单元，用于基于所测量的光学特性控制组织破坏介质的供应。

公开(公告)号：US5927997A

公开(公告)日：1999-07-27

申请号：US858370

申请日：1997-05-19

申请人： Anders Ruland ,  Claes von Scheele ,  Gert Nilsson ,  Goran Pehrsson ,  Johan Uggmark

发明人： Anders Ruland ,  Claes von Scheele ,  Gert Nilsson ,  Goran Pehrsson ,  Johan Uggmark

IPC分类号： G06F1/18 ,  G06F1/16 ,  G09F9/00 ,  H01R12/71 ,  H01R13/24 ,  H01R13/72 ,  H01R35/04 ,  H04M1/02 ,  H01R39/00

CPC分类号： H04M1/0216 ,  G06F1/1616 ,  G06F1/1679 ,  G06F1/1681 ,  G06F1/1683 ,  H01R13/2414 ,  H01R23/68

摘要： The present invention relates to a device for connecting two electrical circuits (2,17;15,16) by a connection which permits that the two circuits easily can be separated and reunited again at the same time as interference and scratching noise in the connection mechanism are avoided. A first carrier (14, 28) is movable around a shaft (1), which is fastened onto a second carrier (7, 29). The first carrier (14, 28) can easily be removed from the shaft (1) and refitted again. The first carrier (14, 28) has a projecting part (8, 23, 30), which presses against an electrically conducting elastomer (4,18a-l, 21, 33) localized on the second carrier (7, 29). On the projecting part (8, 23, 30) there is an electrically conducting part (9, 20a-l, 24a-h), which is connected to a first electrical circuit (2,17) localized on the first carrier (14, 28). The electrically conducting elastomer (4,18a-l, 21, 33) is connected to a second electrical circuit (15,16) localized on the second carrier (7, 29). By means of co-operation between the projecting part (8, 23, 30) and the elastomer (4,18a-l, 21,33), an electrical connection between the first (2,17) and the second circuit (15,16) is achieved.

摘要翻译： 本发明涉及一种用于通过连接连接两个电路（2,17; 15,16）的装置，该连接允许两个电路容易地在连接机构中的干扰和划伤噪声的同时被再次分离 被避免。 第一行星架（14,28）可围绕轴（1）移动，轴（1）被固定在第二行星架（7,29）上。 第一托架（14,28）可以容易地从轴（1）移除并再次重新安装。 第一载体（14,28）具有突出部分（8,23,30），该突出部分压靠位于第二载体（7,29）上的导电弹性体（4,18a-1,21,33）。 在突出部分（8,23,30）上，具有导电部分（9,20a-1,24a-h），其连接到局部在第一载体（14）上的第一电路（2,17） 28）。 导电弹性体（4,18a-1,21,33）连接到位于第二载体（7,29）上的第二电路（15,16）。 通过突出部分（8,23,30）和弹性体（4,18a-1,23,33）之间的协作，第一（2,17）和第二电路（15）之间的电连接 16）。

公开(公告)号：US5339817A

公开(公告)日：1994-08-23

申请号：US852145

申请日：1992-04-30

申请人： Gert Nilsson

发明人： Gert Nilsson

IPC分类号： G01P5/00 ,  A61B5/026 ,  A61B5/0285 ,  A61B6/00

CPC分类号： A61B5/0261

摘要： The invention is directed to a system for the measurement and presentation of flow movements in a fluid to determine blood perfusion in superficial blood vessels of a body organ. The system includes a laser light source (1) generating a laser beam, apparatus for directing the laser beam onto a body part to be examined and for guided movement of the beam over the body part. The beam is moved over the body part in a predetermined scanning pattern (8). The system further includes a receiving part for the beam reflected from the body part, and apparatus for detecting broadening of the frequency of a reflected light beam caused by a Doppler effect. This results in measuring the magnitude of superficial blood circulation in the body part (5) at points scanned by the beam.

摘要翻译： PCT No.PCT / SE90 / 00705 Sec。 一九九二年四月三十日 102（e）日期1992年4月30日PCT 1990年10月30日PCT PCT。 公开号WO91 / 06244 日期1991年5月16日。本发明涉及一种用于测量和呈现流体中的流动运动以确定身体器官的浅表血管中的血液灌注的系统。 该系统包括产生激光束的激光光源（1），用于将激光束引导到待检查的主体部分上的装置，以及用于该光束在身体部分上引导的移动。 光束以预定的扫描图案（8）在身体部分上移动。 该系统还包括用于从身体部分反射的束的接收部分，以及用于检测由多普勒效应引起的反射光束的频率变宽的装置。 这导致在由梁扫描的点处测量身体部分（5）中的表面血液循环的大小。

公开(公告)号：US20070146686A1

公开(公告)日：2007-06-28

申请号：US10592024

申请日：2005-04-18

申请人： Gert Nilsson ,  Folke Sjoberg

发明人： Gert Nilsson ,  Folke Sjoberg

IPC分类号： G01N33/48 ,  A61B19/00

CPC分类号： A61B5/0261

摘要： This invention relates to the non-invasive determination of the degree of vasoactivity in the microcirculation in a tissue caused by a drug, disease, injury normal or pathological regulation. More specifically, the invention relates to a method of determining the influence on microcirculation in living tissue from an irritative agent, drugs, disease, injuries normal or pathological regulation including, illuminating a tissue surface with polarized light, collecting the backscattered light through a polarizing filter, detecting the backscattered and polarized light by a photo-sensitive array, transferring the collected information in digital form to a computing device, separating the collected information into at least two data matrixes, each representing a specific wavelength range and generating an output data matrix by processing corresponding values in at least two data matrixes by an algorithm, wherein each value in said output data matrix represents the amount of influence on the microcirculation in a source point of the tissue. Thereby a representation of the tissue microcirculation is obtained.

摘要翻译： 本发明涉及由药物，疾病，损伤正常或病理调节引起的组织微循环中血管活性程度的非侵入性测定。 更具体地说，本发明涉及一种确定活体组织中微循环对刺激剂，药物，疾病，损伤正常或病理调节的影响的方法，包括用偏振光照射组织表面，通过偏振滤光片收集反向散射光 通过光敏阵列检测反向散射和偏振光，将收集的数字形式的信息传送到计算设备，将收集的信息分离成至少两个数据矩阵，每个数据矩阵表示特定波长范围，并通过以下方式生成输出数据矩阵： 通过算法处理至少两个数据矩阵中的对应值，其中所述输出数据矩阵中的每个值表示对组织的源点中的微循环的影响量。 从而获得组织微循环的表示。

公开(公告)号：US06635210B2

公开(公告)日：2003-10-21

申请号：US09789173

申请日：2001-02-20

申请人： Gert Nilsson ,  Michael Persson

发明人： Gert Nilsson ,  Michael Persson

IPC分类号： B29C4514

CPC分类号： B29C45/14 ,  B29C51/00 ,  B29L2031/3431 ,  B29L2031/3437 ,  H04M1/0202 ,  Y10T428/13

摘要： A method of manufacturing a shell element (13) for an electronic device, said shell element (13) having a front part(5) and at least one part that is angled in relation to said front part (5). The shell element (13) further comprises a formed sheet (6) that constitutes at least a part of the outer surface of said front part (5) and at least a part of said at least one part that is angled in relation to the front of the shell element (13). The method comprises the steps of first forming a sheet (1) to a desired shape including a part that is angled in relation to a front part (5) and then injection molding a plastics material on the back of the formed sheet (6). At least one opening (7) is provided in the angled part of the formed sheet (6) before the plastics material is injection molded on the back of the formed sheet (6) and the at least one opening (7) is left open during the injection molding of the plastics material on the back of the formed sheet (6). A shell element manufactured by this method is also disclosed.

摘要翻译： 一种用于电子设备的壳体元件（13）的制造方法，所述壳体元件（13）具有前部（5）和至少一个与所述前部（5）成一定角度的部分。 外壳元件（13）还包括构成所述前部（5）的外表面的至少一部分的成形片（6），并且所述至少一个部分的至少一部分相对于前部 的壳元件（13）。 该方法包括以下步骤：首先将片材（1）形成为包括相对于前部（5）倾斜的部分的期望形状，然后在成形片材（6）的后部上注塑塑料材料。 在将塑料材料注射成型在成形片材（6）的背面上之后，至少一个开口（7）设置在成形片材（6）的成角度部分中，并且至少一个开口（7）在 在成型片（6）的背面上注塑塑料材料。 还公开了通过该方法制造的壳单元。

公开(公告)号：US5921922A

公开(公告)日：1999-07-13

申请号：US732217

申请日：1996-12-18

申请人： Gert Nilsson ,  Folke Sjoberg

发明人： Gert Nilsson ,  Folke Sjoberg

IPC分类号： G01N27/26 ,  G01N27/416 ,  A61B5/14 ,  G01N27/30

CPC分类号： G01N27/302

摘要： A method and an equipment for determining components, particularly pH, pO.sub.2 and pCO.sub.2 in blood. In order to facilitate the determination of blood gases, one sensor is used for measurement of more than one component. The components are measured at the same measuring point, using an electrode based on antimony. The electrode potential is measured both with and without a known voltage applied over the electrode.

摘要翻译： PCT No.PCT / SE95 / 00446 Sec。 371日期：1996年12月18日 102（e）日期1996年12月18日PCT提交1995年4月24日PCT公布。 WO95 / 29401 PCT出版物 日期1995年11月2日一种用于测定血液中成分，特别是pH，pO2和pCO2的方法和设备。 为了便于血液气体的测定，使用一个传感器来测量多于一个的组分。 在相同的测量点使用基于锑的电极测量组分。 在电极上施加和不使用已知电压来测量电极电位。

公开(公告)号：US5361769A

公开(公告)日：1994-11-08

申请号：US39410

申请日：1993-04-21

申请人： Gert Nilsson

发明人： Gert Nilsson

IPC分类号： A61B5/0285 ,  A61B5/026 ,  G01P5/00 ,  G01P5/26 ,  G01P13/00

CPC分类号： G01P5/26 ,  A61B5/0261

摘要： The invention relates to a method and to a system for reducing the distance-dependent amplification factor when measuring fluid flow movements with the aid of an image-producing laser-Doppler technique, in particular when measuring blood perfusion through tissue. A laser beam source (1) directs a laser beam (2) onto a measurement object (5), which scatters and reflects the beam (2). The reflected light is received by a detector (9) which senses the broadening in frequency caused by the Doppler effect. One or more lenses (12: 15, 16) are placed in the path of the beam (2) and are intended to maintain constant the number of coherence areas on the detecting surface of the detector and independent of the distance between detector and measurement object.

摘要翻译： PCT No.PCT / SE92 / 00570 Sec。 371日期：1993年4月21日 102（e）日期1993年4月21日PCT提交1992年8月21日PCT公布。 出版物WO93 / 03667 日期1993年3月4日。本发明涉及一种在借助于成像激光多普勒技术测量流体流动时减小距离相关放大因子的方法和系统，特别是当测量血液灌注通过 组织。 激光束源（1）将激光束（2）引导到测量对象（5）上，测量对象（5）散射并反射光束（2）。 反射光被检测器（9）接收，检测器（9）感测由多普勒效应引起的频率变宽。 一个或多个透镜（12：15,16）被放置在光束（2）的路径中，并且旨在保持检测器的检测表面上的相干区域的数量不变，并且与检测器和测量对象之间的距离无关 。