公开(公告)号：US20050043528A1

公开(公告)日：2005-02-24

申请号：US10912362

申请日：2004-08-06

申请人： Gil Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles Kunsch

发明人： Gil Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles Kunsch

IPC分类号： B82B1/00 ,  A61K39/09 ,  A61P31/04 ,  C07K14/24 ,  C07K14/315 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/566 ,  C07H21/04

CPC分类号： C07K14/24 ,  C07K14/315

摘要： The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

摘要翻译： 本发明涉及来自粪肠球菌的新基因及其编码的多肽。 还提供载体，宿主细胞，抗体及其制备方法。 本发明还涉及用于鉴定粪肠球菌多肽活性的激动剂和拮抗剂的筛选方法。 本发明还涉及在生物样品中检测肠球菌核酸，多肽和抗体的诊断方法。 本发明还涉及用于预防或减轻肠球菌感染的新型疫苗。

公开(公告)号：US06913907B2

公开(公告)日：2005-07-05

申请号：US10206576

申请日：2002-07-29

申请人： Gil H. Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles A. Kunsch

发明人： Gil H. Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles A. Kunsch

IPC分类号： B82B1/00 ,  A61K39/09 ,  A61P31/04 ,  C07K14/24 ,  C07K14/315 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/566 ,  C07H21/04 ,  C12N15/00 ,  C12P21/06

CPC分类号： C07K14/24 ,  C07K14/315

摘要： The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

摘要翻译： 本发明涉及来自粪肠球菌的新基因及其编码的多肽。 还提供载体，宿主细胞，抗体及其制备方法。 本发明还涉及用于鉴定粪肠球菌多肽活性的激动剂和拮抗剂的筛选方法。 本发明还涉及在生物样品中检测肠球菌核酸，多肽和抗体的诊断方法。 本发明还涉及用于预防或减轻肠球菌感染的新型疫苗。

公开(公告)号：US06448043B1

公开(公告)日：2002-09-10

申请号：US09071035

申请日：1998-05-04

申请人： Gil H. Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles A. Kunsch

发明人： Gil H. Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles A. Kunsch

IPC分类号： C07H2104

CPC分类号： C07K14/24 ,  C07K14/315

摘要： The present invention relates to a novel gene from E. faecalis, EF040, and the encoded polypeptides. Also provided are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis EF040 polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus EF040 nucleic acids, encoded polypeptides and anti-EF040 antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

摘要翻译： 本发明涉及来自粪肠球菌的新基因，EF040和编码的多肽。 还提供了载体，宿主细胞，抗体及其制备方法。 本发明进一步涉及用于鉴定粪肠球菌EF040多肽活性的激动剂和拮抗剂的筛选方法。 本发明还涉及在生物样品中检测肠球菌EF040核酸，编码多肽和抗EF040抗体的诊断方法。 本发明还涉及用于预防或减轻肠球菌感染的新型疫苗。