公开(公告)号：US20100105653A1

公开(公告)日：2010-04-29

申请号：US12545322

申请日：2009-08-21

申请人： Gilbert Besong ,  Christopher Thomas Brain ,  Clinton A. Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Huo ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Mortenson ,  Troy Smith ,  Moo Je Sung ,  Steven Woodhead ,  Wojciech Wrona

发明人： Gilbert Besong ,  Christopher Thomas Brain ,  Clinton A. Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Huo ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Mortenson ,  Troy Smith ,  Moo Je Sung ,  Steven Woodhead ,  Wojciech Wrona

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61K31/551 ,  C12N5/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。 还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。 此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

公开(公告)号：US09416136B2

公开(公告)日：2016-08-16

申请号：US14158358

申请日：2014-01-17

申请人： Gilbert Besong ,  Christopher Thomas Brain ,  Clinton A Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Hou ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Mortenson ,  Troy Smith ,  Moo Je Sung ,  Steven Woodhead ,  Wojciech Wrona ,  Bharat Lagu

发明人： Gilbert Besong ,  Christopher Thomas Brain ,  Clinton A Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Hou ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Mortenson ,  Troy Smith ,  Moo Je Sung ,  Steven Woodhead ,  Wojciech Wrona ,  Bharat Lagu

IPC分类号： A61K31/519 ,  A61P35/04 ,  C07D487/04 ,  C07D487/08

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

公开(公告)号：US20140135312A1

公开(公告)日：2014-05-15

申请号：US14158358

申请日：2014-01-17

申请人： Gilbert BESONG ,  Christopher Thomas Brain ,  Clinton A. Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Huo ,  Steven Howard ,  Yue Ll ,  Yipin Lu ,  Paul Mortenston ,  Troy Smith ,  Moo Je Sung ,  Steven Woodhead ,  Wojciech Wrona ,  Bharat Lagu

发明人： Gilbert BESONG ,  Christopher Thomas Brain ,  Clinton A. Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Huo ,  Steven Howard ,  Yue Ll ,  Yipin Lu ,  Paul Mortenston ,  Troy Smith ,  Moo Je Sung ,  Steven Woodhead ,  Wojciech Wrona ,  Bharat Lagu

IPC分类号： C07D487/08 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。 还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。 此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

公开(公告)号：US20110152244A1

公开(公告)日：2011-06-23

申请号：US13060154

申请日：2009-08-20

申请人： Gilbert Besong ,  Christopher Thomas Brain ,  Clinton A. Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Huo ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Morteson ,  Troy Smith ,  Moo Sung ,  Steven Woodhead ,  Wojciech Wrona

发明人： Gilbert Besong ,  Christopher Thomas Brain ,  Clinton A. Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Huo ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Morteson ,  Troy Smith ,  Moo Sung ,  Steven Woodhead ,  Wojciech Wrona

IPC分类号： C07D487/04 ,  A61K31/497 ,  A61K31/519 ,  A61K31/551 ,  A61K31/5377 ,  A61K31/501 ,  C12N9/99 ,  A61P35/04 ,  A61P29/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。 还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。 此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

公开(公告)号：US20070124604A1

公开(公告)日：2007-05-31

申请号：US11010477

申请日：2004-12-14

申请人： Andy Feldstein ,  Robert Woodward ,  Gregory Smith ,  Barry Weinberger ,  Troy Smith ,  Shawn Long ,  Michael Wexler

发明人： Andy Feldstein ,  Robert Woodward ,  Gregory Smith ,  Barry Weinberger ,  Troy Smith ,  Shawn Long ,  Michael Wexler

IPC分类号： G06F1/00

CPC分类号： H04M11/066

摘要： An improved data modem (IDM) and method includes a communication processor module, a mass storage module, a power converter module, and one or more DSP modules. The communication processor module utilizes commercial off-the-shelf components as well as electrically programmable logic devices (EPLD), which are programmed to provide a watchdog timer, programmable interrupt controller, flash page addressing, ISA bus decoder and controller, and various circuits and logic.

摘要翻译： 改进的数据调制解调器（IDM）和方法包括通信处理器模块，大容量存储模块，功率转换器模块和一个或多个DSP模块。 通信处理器模块使用商业现成的组件以及电可编程逻辑器件（EPLD），其被编程为提供看门狗定时器，可编程中断控制器，闪存寻址，ISA总线解码器和控制器以及各种电路和 逻辑。

公开(公告)号：US07296165B2

公开(公告)日：2007-11-13

申请号：US11010477

申请日：2004-12-14

申请人： Andy A. Feldstein ,  Robert A. Woodward ,  Gregory N. Smith ,  Barry P. Weinberger ,  Troy Smith ,  Shawn M. Long ,  Michael M. Wexler

发明人： Andy A. Feldstein ,  Robert A. Woodward ,  Gregory N. Smith ,  Barry P. Weinberger ,  Troy Smith ,  Shawn M. Long ,  Michael M. Wexler

IPC分类号： G06F1/00 ,  G06F11/00

CPC分类号： H04M11/066

摘要： An improved data modem (IDM) and method includes a communication processor module, a mass storage module, a power converter module, and one or more DSP modules. The communication processor module utilizes commercial off-the-shelf components as well as electrically programmable logic devices (EPLD), which are programmed to provide a watchdog timer, programmable interrupt controller, flash page addressing, ISA bus decoder and controller, and various circuits and logic.

摘要翻译： 改进的数据调制解调器（IDM）和方法包括通信处理器模块，大容量存储模块，功率转换器模块和一个或多个DSP模块。 通信处理器模块使用商业现成的组件以及电可编程逻辑器件（EPLD），其被编程为提供看门狗定时器，可编程中断控制器，闪存寻址，ISA总线解码器和控制器以及各种电路和 逻辑。

公开(公告)号：US20130042453A1

公开(公告)日：2013-02-21

申请号：US13213125

申请日：2011-08-19

申请人： Peter Alexander Szpara ,  Timothy John Reed ,  Troy Smith ,  Julie Anne Sunstein ,  Wayne Uhrick

发明人： Peter Alexander Szpara ,  Timothy John Reed ,  Troy Smith ,  Julie Anne Sunstein ,  Wayne Uhrick

IPC分类号： B23P21/00 ,  B23P11/00

CPC分类号： F16C25/06 ,  F16C19/182 ,  F16C19/548 ,  F16C2229/00 ,  F16C2361/61 ,  F16H2057/02043 ,  F16H2057/0221 ,  Y10T29/49776 ,  Y10T29/53061

摘要： The present disclosure relates to pinion assembly preloading systems. Disclosed are systems including a press actuator configured to apply an axial force against a pinion assembly; a force sensor configured to measure a reaction force at the pinion assembly; and a controller configured to control the press actuator according to a change in the reaction force.

摘要翻译： 本公开涉及小齿轮组件预加载系统。 公开了包括压力致动器的系统，其构造成对小齿轮组件施加轴向力; 力传感器，构造成测量小齿轮组件处的反作用力; 以及控制器，其被配置为根据反作用力的变化来控制所述按压致动器。

公开(公告)号：US07293128B2

公开(公告)日：2007-11-06

申请号：US11010478

申请日：2004-12-14

申请人： Andy A. Feldstein ,  Robert A. Woodward ,  Gregory N. Smith ,  Barry P. Weinberger ,  Troy Smith ,  Shawn M. Long ,  Michael M. Wexler

发明人： Andy A. Feldstein ,  Robert A. Woodward ,  Gregory N. Smith ,  Barry P. Weinberger ,  Troy Smith ,  Shawn M. Long ,  Michael M. Wexler

IPC分类号： G06F13/00

CPC分类号： H04M11/066

摘要： An improved data modem (IDM) and method includes a communication processor module, a mass storage module, a power converter module, and one or more DSP modules. The communication processor module utilizes commercial off-the-shelf components as well as electrically programmable logic devices (EPLD), which are programmed to provide a watchdog timer, programmable interrupt controller, flash page addressing, ISA bus decoder and controller, and various circuits and logic.

公开(公告)号：US06839792B2

公开(公告)日：2005-01-04

申请号：US10142875

申请日：2002-05-13

申请人： Andy A. Feldstein ,  Robert A. Woodward ,  Gregory N. Smith ,  Barry P. Weinberger ,  Troy Smith ,  Shawn Long ,  Michael M. Wexler

发明人： Andy A. Feldstein ,  Robert A. Woodward ,  Gregory N. Smith ,  Barry P. Weinberger ,  Troy Smith ,  Shawn Long ,  Michael M. Wexler

IPC分类号： G06F1/12 ,  G06F13/00 ,  G06F13/36 ,  H04M11/06

CPC分类号： H04M11/066

摘要： An improved data modem (IDM) and method includes a communication processor module, a mass storage module, a power converter module, and one or more DSP modules. The communication processor module utilizes commercial off-the-shelf components as well as programmable logic devices (EPLD), which are programmed to provide a watchdog timer, programmable interrupt controller, flash page addressing, ISA bus decoder and controller, and various circuits and logic.

公开(公告)号：US08957068B2

公开(公告)日：2015-02-17

申请号：US14347481

申请日：2012-09-26

申请人： Thomas Raymond Caferro ,  Young Shin Cho ,  Abran Q. Costales ,  Huangshu Lei ,  Francois Lenoir ,  Julian Roy Levell ,  Gang Liu ,  Mark G. Palermo ,  Keith Bruce Pfister ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  Troy Smith ,  James Clifford Sutton ,  Bakary-Barry Toure ,  Fan Yang ,  Qian Zhao

发明人： Thomas Raymond Caferro ,  Young Shin Cho ,  Abran Q. Costales ,  Huangshu Lei ,  Francois Lenoir ,  Julian Roy Levell ,  Gang Liu ,  Mark G. Palermo ,  Keith Bruce Pfister ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  Troy Smith ,  James Clifford Sutton ,  Bakary-Barry Toure ,  Fan Yang ,  Qian Zhao

IPC分类号： C07D413/04 ,  C07D413/14 ,  A61K31/506 ,  C07D487/04 ,  C07D471/04 ,  C07D487/08 ,  C07D417/14 ,  C07D498/10

CPC分类号： C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D498/10 ,  C07D513/04

摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。 本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。 本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。