-
1.发明授权Use of (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propy lamine to increase gastric discharge in a subject 失效（+） - 1 - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基正丙胺用于增加受试者胃排出量
公开(公告)号：US5266599A
公开(公告)日：1993-11-30
申请号：US931994
申请日：1992-08-19
申请人： Gilbert G. Aubard , Alain P. Calvet , Agnes Grouhel , Henri Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman
发明人： Gilbert G. Aubard , Alain P. Calvet , Agnes Grouhel , Henri Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman
IPC分类号： C07C217/48 , A61K31/135
CPC分类号： C07C217/48 , Y10S514/928
摘要： (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine of formula ##STR1## is a medicament of use in gastroenterology.
摘要翻译： 式（IMA）的（+） - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基正丙胺是用于胃肠病学的药物。
-
2.发明授权
公开(公告)号：US5017723A
公开(公告)日：1991-05-21
申请号：US484493
申请日：1990-02-26
申请人： Gilbert G. Aubard , Alain P. Calvet , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman , Claude D. Soulard , James P. Hudspeth , Yuan Lin
发明人： Gilbert G. Aubard , Alain P. Calvet , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman , Claude D. Soulard , James P. Hudspeth , Yuan Lin
IPC分类号： C07C211/28 , C07C211/29 , C07C217/58 , C07C217/60 , C07C217/74 , C07C255/42 , C07C255/43 , C07C265/08 , C07D307/52 , C07D333/20 , C07D409/06
CPC分类号： C07D409/06 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/60 , C07C217/74 , C07C255/42 , C07C255/43 , C07C265/08 , C07D307/52 , C07D333/20 , C07C2101/02
摘要： Substituted ethylamines of the formula ##STR1## wherein R.sub.1 is phenyl optionally mono-, di- or trisubstituted by halogen, lower alkyl, lower haloalkyl or lower alkoxy, or is an aromatic heterocycle having 5 to 7 chains wherein the heteroatom is nitrogen, oxygen or sulfur,R.sub.2 is lower alkyl,R.sub.3 and R.sub.4, each independently, represent hydrogen, lower alkyl or lower alkenyl,R.sub.5 is phenyl optionally mono-, di- or trisubstituted by halogen or lower alkoxy or is an aromatic heterocycle having 5 to 7 chains wherein the heteroatom is nitrogen, oxygen or sulfur andQ represents a --CH.dbd.CH-- ethylene group or a 1,2-diyl ##STR2## propane group, their acid addition salts and their optically active forms. These substituted ethylamines have psycotropic properties and are useful as medicines.
摘要翻译： 下式的取代的乙胺（I）其中R1是任选被卤素，低级烷基，低级卤代烷基或低级烷氧基单取代，二取代或三取代的苯基，或是具有5至7个链的芳族杂环，其中杂原子是氮 ，氧或硫，R 2是低级烷基，R 3和R 4各自独立地代表氢，低级烷基或低级烯基，R 5是任选地被卤素或低级烷氧基单，二或三取代的苯基，或者是具有5至 7个链，其中杂原子是氮，氧或硫，Q表示-CH = CH-亚乙基或1,2-二基丙烷基，它们的酸加成盐及其光学活性形式。 这些取代的乙胺具有抗菌性，可用作药物。
-
3.发明授权N-cycloalkylalkylamines, process for their preparation, their use as a medicament and their synthesis intermediates 失效N-环丙基甲基亚胺，其制备方法，作为药物及其合成中间体的使用
公开(公告)号：US5089639A
公开(公告)日：1992-02-18
申请号：US645405
申请日：1991-01-24
申请人： Gilbert G. Aubard , Alain P. Calvet , Jean-Pierre Defaux , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois F. Roman , James P. Hudspeth , Yuan Lin
发明人： Gilbert G. Aubard , Alain P. Calvet , Jean-Pierre Defaux , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois F. Roman , James P. Hudspeth , Yuan Lin
IPC分类号： A61K31/135 , A61P1/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , C07C57/42 , C07C57/58 , C07C67/00 , C07C209/00 , C07C211/27 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/62 , C07C217/64 , C07C233/03 , C07C233/05 , C07C233/08 , C07C233/12 , C07C233/13 , C07C233/21 , C07C241/00 , C07C255/24 , C07C255/30 , C07C255/42 , C07C265/06 , C07C265/08
CPC分类号： C07C265/08 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/62 , C07C233/03 , C07C233/05 , C07C233/12 , C07C233/13 , C07C233/21 , C07C255/42 , C07C2101/02 , C07C2101/04 , C07C2101/08 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： N-Cycloalkylalkylamines of formula I: ##STR1## in which: R1 is phenyl which is optionally mono-, di- or trisubstituted by halogens or lower alkyl, haloalkyl or lower alkoxy radicals, or is an aromatic heterocyclic radical having 5 to 7 chain members, in which the hetero atom is nitrogen, oxygen or sulphur,R2 is lower alkyl,R3 is hydrogen or lower alkyl,m has the value of 1 or 2,R4 is cycloalkyl --CH(CH2)n, in which a carbon atom may carry a radical Rx, which is lower alkyl or phenyl; and in which n has the values from 2 to 5,R5 is phenyl, which can be mono-, di- or trisubstituted by halogens or by lower alkoxy radicals, andQ represents an ethylene-1,2-diyl group --CH.dbd.CH-- or a cyclopropane-1,2-diyl group ##STR2##
-
4.发明授权(+)-1-[(3 ,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-N-propylamine, process for preparing it and its therapeutical use 失效（+） - 1 - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基-N-丙胺，其制备方法及其治疗用途
公开(公告)号：US5245080A
公开(公告)日：1993-09-14
申请号：US931957
申请日：1992-08-19
IPC分类号： C07C217/48
CPC分类号： C07C217/48
摘要： (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine of formula ##STR1## is a medicament of use in gastroenterology.
摘要翻译： 式（IMA）的（+） - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基正丙胺是用于胃肠病学的药物。
-
5.发明授权Aminoethylimidazole and cytoprotective and gastric antisecretory composition containing the same 失效氨基乙基咪唑和细胞保护作用及含胃酸分泌物组合物
公开(公告)号：US4734428A
公开(公告)日：1988-03-29
申请号：US872481
申请日：1986-06-10
申请人： Gilbert G. Aubard , Jacques Bure , Agnes G. Grouhel , Jean-Louis Junien , Veronique J. Lelievre , Xavier B. Pascaud , Claude P. Roux
发明人： Gilbert G. Aubard , Jacques Bure , Agnes G. Grouhel , Jean-Louis Junien , Veronique J. Lelievre , Xavier B. Pascaud , Claude P. Roux
IPC分类号： A61K31/415 , A61P1/04 , C07D233/61 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Aminoethyl imidazole of formula: ##STR1## in which R.sub.1 is a lower alkyl, R.sub.2 is a phenyl or phenoxy radical, optionally substituted by a halogen atom or a lower alkoxy radical, R.sub.3,R.sub.4 and R.sub.5 are a hydrogen atom or a lower alkyl radical and x, y and z have the value 0 or 1, but the values of y and z cannot be the same, together with their acid addition salts with acids.Cytoprotective medicament.
摘要翻译： 其中R 1是低级烷基，R 2是任选被卤素原子或低级烷氧基取代的苯基或苯氧基的氨基乙基咪唑，其中R 3，R 4和R 5是氢原子或低级烷基 并且x，y和z的值为0或1，但y和z的值不能与其与酸的酸加成盐一起相同。 细胞保护性药物。
-
6.发明授权N-cycloalkylalkylamines, process for their preparation, their use as medicament and their synthesis intermediates 失效N-环烷基烷基胺，其制备方法，它们作为药物及其合成中间体的用途
公开(公告)号：US5034419A
公开(公告)日：1991-07-23
申请号：US484403
申请日：1990-02-26
申请人： Gilbert G. Aubard , Alain P. Calvet , Jean-Pierre DeFaux , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier Pascaud , Francois F. Roman , James P. Hudspeth , Yuan Lin
发明人： Gilbert G. Aubard , Alain P. Calvet , Jean-Pierre DeFaux , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier Pascaud , Francois F. Roman , James P. Hudspeth , Yuan Lin
IPC分类号： A61K31/135 , A61P1/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , C07C57/42 , C07C57/58 , C07C67/00 , C07C209/00 , C07C211/27 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/62 , C07C217/64 , C07C233/03 , C07C233/05 , C07C233/08 , C07C233/12 , C07C233/13 , C07C233/21 , C07C241/00 , C07C255/24 , C07C255/30 , C07C255/42 , C07C265/06 , C07C265/08
CPC分类号： C07C265/08 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/62 , C07C233/03 , C07C233/05 , C07C233/12 , C07C233/13 , C07C233/21 , C07C255/42 , C07C2101/02 , C07C2101/04 , C07C2101/08 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： N-Cycloalkylalkylamines of formula I: ##STR1## in which: R1 is phenyl which is optionally mono-, di- or trisubstituted by halogens or lower alkyl, haloalkyl or lower alkoxy radicals, or is an aromatic heterocyclic radical having 5 to 7 chain members, in which the hetero atom is nitrogen, oxygen or sulphur,R2 is lower alkyl,R3 is hydrogen or lower alkyl,m has the value of 1 or 2,R4 is cycloalkyl --CH(CH2)n, in which a carbon atom may carry a radical Rx, which is lower alkyl or phenyl; and in which n has the values from 2 to 5,R5 is phenyl, which can be mono-, di- or trisubstituted by halogens or by lower alkoxy radicals, andQ represents an ethylene-1,2-diyl group --CH.dbd.CH-- or a cyclopropane-1,2-diyl group ##STR2##
摘要翻译： 式I的N-环烷基烷基胺：其中：R 1是任选被卤素或低级烷基，卤代烷基或低级烷氧基单取代，二取代或三取代的苯基，或是具有5-7个链的芳族杂环基 成员，其中杂原子是氮，氧或硫，R2是低级烷基，R3是氢或低级烷基，m的值是1或2，R4是环烷基-CH（CH2）n，其中碳原子 可以携带基团Rx，它是低级烷基或苯基; 并且其中n具有2至5的值，R 5是苯基，其可以被卤素或低级烷氧基单取代，二取代或三取代，并且Q表示乙烯-1,2-二基-CH = CH - 或环丙烷-1,2-二基
-
公开(公告)号：US4761400A
公开(公告)日：1988-08-02
申请号：US816617
申请日：1986-01-06
申请人： Bernard J. M. Doat , Jean-Francois J. Letavernier , Gilbert G. Aubard , Jean B. Llull , Alain P. Calvet , Jean-Louis Junien
发明人： Bernard J. M. Doat , Jean-Francois J. Letavernier , Gilbert G. Aubard , Jean B. Llull , Alain P. Calvet , Jean-Louis Junien
CPC分类号： A61K31/70 , A61K47/36 , A61K9/0056
摘要： Lactulose-based laxative composition which is in the form of a jelly with a viscosity at 20.degree. C. measured on the Brookfield viscosimeter between 15,000 and 30,000 centipoises, a refractive index at 20.degree. C. between 1.430 and 1.445 and a pH between 3 and 4.
摘要翻译： 乳果糖基的泻药组合物为粘稠度为20℃的果冻形式，在Brookfield粘度计上测定为15,000至30,000厘泊，折射率为20℃，介于1.430和1.445之间，pH在3和 4。
-
8.发明授权Hydrocortisone-17-oxo-21-thioesters, their preparation and their uses as medicaments 失效氢化可的松-17-氧代-21-硫酯，它们的制备及其作为药物的用途
公开(公告)号：US5021408A
公开(公告)日：1991-06-04
申请号：US71315
申请日：1987-07-09
申请人： Gilbert G. Aubard , Agnes G. Grouhel , Jean-Louis Junien , Claude P. Roux , Dieran R. Torossian
发明人： Gilbert G. Aubard , Agnes G. Grouhel , Jean-Louis Junien , Claude P. Roux , Dieran R. Torossian
CPC分类号： C07J31/006
摘要： 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflamatory agents.
-
公开(公告)号：US4933331A
公开(公告)日：1990-06-12
申请号：US794737
申请日：1985-11-04
申请人： Gilbert G. Aubard , Agnes G. Grouhel , Jean-Louis Junien , Claude P. Roux , Dieran R. Torossian
发明人： Gilbert G. Aubard , Agnes G. Grouhel , Jean-Louis Junien , Claude P. Roux , Dieran R. Torossian
CPC分类号： C07J31/006
摘要： 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflammatory agents.
摘要翻译： 3,20-二酮-11β-羟基孕-4-烯-22-硫代乙酸酯-17-丁酸酯和3,20-二酮-11β-羟基孕-4-烯-21-硫代丙酸酯-17-丁酸酯是抗炎的 代理商
-
公开(公告)号：US4301163A
公开(公告)日：1981-11-17
申请号：US164931
申请日：1980-07-01
IPC分类号： A61K31/13 , A61K31/135 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61P23/00 , A61P25/04 , C07C67/00 , C07C213/00 , C07C217/04 , C07C217/48 , C07D213/24 , C07D213/30 , C07D213/64 , C07D213/65 , C07C87/28 , C07D213/36
CPC分类号： C07D213/30 , C07D213/64 , C07D213/65
摘要： Amino-ether oxides of formula: ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 and R.sub.3 which are the same or different are hydrogen or lower alkyl, R.sub.4 is a phenyl or phenoxy nucleus optionally monosubstituted to trisubstituted by substituents which are the same or different, halogen or lower alkoxy, R.sub.5 is a phenyl radical optionally monosubstituted to trisubstituted by substituents which are the same or different, halogen, lower alkyl, lower alkoxy or nitro, a pyridyl radical or a lower alkyl radical, n is equal to zero, 1 or 2 and p is an integer from 0 to 9, m and q are equal to zero or 1.Local and spasmolytic anaesthetics.
摘要翻译： 下式的氨基醚氧化物：其中R 1是低级烷基，R 2和R 3相同或不同的是氢或低级烷基，R 4是苯基或苯氧基，任选地被相同或不同的取代基单取代至三取代的苯基或苯氧基， 不同的卤素或低级烷氧基，R5是任选被相同或不同的取代基单取代至三取代的苯基，卤素，低级烷基，低级烷氧基或硝基，吡啶基或低级烷基，n等于零， 1或2，p为0至9的整数，m和q等于零或1.局部和解痉麻醉剂。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.038 秒)
