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1.发明授权
公开(公告)号：US5017723A
公开(公告)日：1991-05-21
申请号：US484493
申请日：1990-02-26
申请人： Gilbert G. Aubard , Alain P. Calvet , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman , Claude D. Soulard , James P. Hudspeth , Yuan Lin
发明人： Gilbert G. Aubard , Alain P. Calvet , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman , Claude D. Soulard , James P. Hudspeth , Yuan Lin
IPC分类号： C07C211/28 , C07C211/29 , C07C217/58 , C07C217/60 , C07C217/74 , C07C255/42 , C07C255/43 , C07C265/08 , C07D307/52 , C07D333/20 , C07D409/06
CPC分类号： C07D409/06 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/60 , C07C217/74 , C07C255/42 , C07C255/43 , C07C265/08 , C07D307/52 , C07D333/20 , C07C2101/02
摘要： Substituted ethylamines of the formula ##STR1## wherein R.sub.1 is phenyl optionally mono-, di- or trisubstituted by halogen, lower alkyl, lower haloalkyl or lower alkoxy, or is an aromatic heterocycle having 5 to 7 chains wherein the heteroatom is nitrogen, oxygen or sulfur,R.sub.2 is lower alkyl,R.sub.3 and R.sub.4, each independently, represent hydrogen, lower alkyl or lower alkenyl,R.sub.5 is phenyl optionally mono-, di- or trisubstituted by halogen or lower alkoxy or is an aromatic heterocycle having 5 to 7 chains wherein the heteroatom is nitrogen, oxygen or sulfur andQ represents a --CH.dbd.CH-- ethylene group or a 1,2-diyl ##STR2## propane group, their acid addition salts and their optically active forms. These substituted ethylamines have psycotropic properties and are useful as medicines.
摘要翻译： 下式的取代的乙胺（I）其中R1是任选被卤素，低级烷基，低级卤代烷基或低级烷氧基单取代，二取代或三取代的苯基，或是具有5至7个链的芳族杂环，其中杂原子是氮 ，氧或硫，R 2是低级烷基，R 3和R 4各自独立地代表氢，低级烷基或低级烯基，R 5是任选地被卤素或低级烷氧基单，二或三取代的苯基，或者是具有5至 7个链，其中杂原子是氮，氧或硫，Q表示-CH = CH-亚乙基或1,2-二基丙烷基，它们的酸加成盐及其光学活性形式。 这些取代的乙胺具有抗菌性，可用作药物。
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2.发明授权N-cycloalkylalkylamines, process for their preparation, their use as a medicament and their synthesis intermediates 失效N-环丙基甲基亚胺，其制备方法，作为药物及其合成中间体的使用
公开(公告)号：US5089639A
公开(公告)日：1992-02-18
申请号：US645405
申请日：1991-01-24
申请人： Gilbert G. Aubard , Alain P. Calvet , Jean-Pierre Defaux , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois F. Roman , James P. Hudspeth , Yuan Lin
发明人： Gilbert G. Aubard , Alain P. Calvet , Jean-Pierre Defaux , Claude J. Gouret , Agnes M. Grouhel , Henry L. Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois F. Roman , James P. Hudspeth , Yuan Lin
IPC分类号： A61K31/135 , A61P1/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , C07C57/42 , C07C57/58 , C07C67/00 , C07C209/00 , C07C211/27 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/62 , C07C217/64 , C07C233/03 , C07C233/05 , C07C233/08 , C07C233/12 , C07C233/13 , C07C233/21 , C07C241/00 , C07C255/24 , C07C255/30 , C07C255/42 , C07C265/06 , C07C265/08
CPC分类号： C07C265/08 , C07C211/28 , C07C211/29 , C07C217/58 , C07C217/62 , C07C233/03 , C07C233/05 , C07C233/12 , C07C233/13 , C07C233/21 , C07C255/42 , C07C2101/02 , C07C2101/04 , C07C2101/08 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： N-Cycloalkylalkylamines of formula I: ##STR1## in which: R1 is phenyl which is optionally mono-, di- or trisubstituted by halogens or lower alkyl, haloalkyl or lower alkoxy radicals, or is an aromatic heterocyclic radical having 5 to 7 chain members, in which the hetero atom is nitrogen, oxygen or sulphur,R2 is lower alkyl,R3 is hydrogen or lower alkyl,m has the value of 1 or 2,R4 is cycloalkyl --CH(CH2)n, in which a carbon atom may carry a radical Rx, which is lower alkyl or phenyl; and in which n has the values from 2 to 5,R5 is phenyl, which can be mono-, di- or trisubstituted by halogens or by lower alkoxy radicals, andQ represents an ethylene-1,2-diyl group --CH.dbd.CH-- or a cyclopropane-1,2-diyl group ##STR2##
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3.发明授权Use of (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propy lamine to increase gastric discharge in a subject 失效（+） - 1 - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基正丙胺用于增加受试者胃排出量
公开(公告)号：US5266599A
公开(公告)日：1993-11-30
申请号：US931994
申请日：1992-08-19
申请人： Gilbert G. Aubard , Alain P. Calvet , Agnes Grouhel , Henri Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman
发明人： Gilbert G. Aubard , Alain P. Calvet , Agnes Grouhel , Henri Jacobelli , Jean-Louis Junien , Xavier B. Pascaud , Francois J. Roman
IPC分类号： C07C217/48 , A61K31/135
CPC分类号： C07C217/48 , Y10S514/928
摘要： (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine of formula ##STR1## is a medicament of use in gastroenterology.
摘要翻译： 式（IMA）的（+） - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基正丙胺是用于胃肠病学的药物。
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公开(公告)号：US5082937A
公开(公告)日：1992-01-21
申请号：US584150
申请日：1990-09-18
IPC分类号： A61K31/55 , A61P1/04 , A61P3/04 , A61P25/00 , A61P25/04 , A61P43/00 , C07D471/06 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： Benzodiazepines of formula ##STR1## in which R.sup.9 is hydrogen or chlorine, R10 is phenyl, possibly substituted, R11 is hydrogen, R12 is oxygen or sulphur, R13 is an NH group, Ar is aromatic or heteroaromatic comprising one or more rings and in which, in particular, A is an ethylene or trimethylene bridge; e is 1 or 2; which are gastrin antagonists and/or central antagonists of cholecystokinin.
摘要翻译： 式（I）的苯并二氮杂其中R 9为氢或氯，R 10为苯基，可能被取代，R 11为氢，R 12为氧或硫，R 13为NH基，Ar为包含一个或多个环的芳族或杂芳族 其中A特别是乙烯或三亚甲基桥; e为1或2; 其为胃泌素拮抗剂和/或胆囊收缩素的中枢拮抗剂。
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5.发明授权Benzodiazepines, process and intermediates for the preparation thereof and their application in therapy 失效苯二氮卓类，其制备方法和中间体及其在治疗中的应用
公开(公告)号：US4929614A
公开(公告)日：1990-05-29
申请号：US337940
申请日：1989-04-14
IPC分类号： A61K31/55 , A61P1/00 , A61P1/16 , A61P25/00 , A61P25/04 , A61P25/18 , C07D471/06 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： Benzodiazepines of formula ##STR1## in which R.sub.1 is H of halogen, R.sub.2 is H or halogen, Ar is indolyl, phenyl, naphthyl, indolyl monosubstituted with a halogen or with a methoxy or phenyl mono-, di- or trisubstituted with a halogen or with a methoxy or with a trifluoromethyl group, and n is 2 or 3; and their optical isomers.
摘要翻译： 式（I）的苯并二氮杂其中R 1为H的卤素，R 2为H或卤素，Ar为吲哚基，苯基，萘基，被卤素单取代的吲哚基或与甲氧基或苯基单 - ，二 - 或三 - 卤素或甲氧基或三氟甲基，n为2或3; 和它们的光学异构体。
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6.发明授权(+)-1-[(3 ,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-N-propylamine, process for preparing it and its therapeutical use 失效（+） - 1 - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基-N-丙胺，其制备方法及其治疗用途
公开(公告)号：US5245080A
公开(公告)日：1993-09-14
申请号：US931957
申请日：1992-08-19
IPC分类号： C07C217/48
CPC分类号： C07C217/48
摘要： (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine of formula ##STR1## is a medicament of use in gastroenterology.
摘要翻译： 式（IMA）的（+） - [（3,4,5-三甲氧基） - 苄氧基甲基] -1-苯基-N，N-二甲基正丙胺是用于胃肠病学的药物。
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7.发明授权Aminoethylimidazole and cytoprotective and gastric antisecretory composition containing the same 失效氨基乙基咪唑和细胞保护作用及含胃酸分泌物组合物
公开(公告)号：US4734428A
公开(公告)日：1988-03-29
申请号：US872481
申请日：1986-06-10
申请人： Gilbert G. Aubard , Jacques Bure , Agnes G. Grouhel , Jean-Louis Junien , Veronique J. Lelievre , Xavier B. Pascaud , Claude P. Roux
发明人： Gilbert G. Aubard , Jacques Bure , Agnes G. Grouhel , Jean-Louis Junien , Veronique J. Lelievre , Xavier B. Pascaud , Claude P. Roux
IPC分类号： A61K31/415 , A61P1/04 , C07D233/61 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Aminoethyl imidazole of formula: ##STR1## in which R.sub.1 is a lower alkyl, R.sub.2 is a phenyl or phenoxy radical, optionally substituted by a halogen atom or a lower alkoxy radical, R.sub.3,R.sub.4 and R.sub.5 are a hydrogen atom or a lower alkyl radical and x, y and z have the value 0 or 1, but the values of y and z cannot be the same, together with their acid addition salts with acids.Cytoprotective medicament.
摘要翻译： 其中R 1是低级烷基，R 2是任选被卤素原子或低级烷氧基取代的苯基或苯氧基的氨基乙基咪唑，其中R 3，R 4和R 5是氢原子或低级烷基 并且x，y和z的值为0或1，但y和z的值不能与其与酸的酸加成盐一起相同。 细胞保护性药物。
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8.发明授权Use of fedotozine in the treatment of functional states of intestinal obstructions 失效使用fedotozine治疗肠梗阻功能状态
公开(公告)号：US5362756A
公开(公告)日：1994-11-08
申请号：US937127
申请日：1992-08-31
IPC分类号： C07C217/48 , A61K31/135
CPC分类号： C07C217/48
摘要： A process for inhibiting functional ileus in a patient, which consists of administering a therapeutically effective dose of (+)-1-1[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N dimethylpropylamine or the addition salt thereof with (-)-tartaric acid is disclosed.
摘要翻译： 一种用于抑制患者功能性肠梗阻的方法，其包括施用治疗有效剂量的（+） - 1-1 [（3,4,5-三甲氧基）苄氧基甲基] -1-苯基-N，N二甲基丙胺或加成 公开了其与（ - ） - 酒石酸的盐。
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