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10 条记录 (耗时 0.078 秒)

    1-[2-(arylsulphonylamino)-1-oxoethyl]piperidine derivatives, their preparation and their therapeutic application
    1.
    发明授权
    1-[2-(arylsulphonylamino)-1-oxoethyl]piperidine derivatives, their preparation and their therapeutic application 失效
    1- [2-（芳基磺酰基氨基）-1-氧代乙基]哌啶衍生物，其制备及其治疗应用

    公开(公告)号：US5453430A

    公开(公告)日：1995-09-26

    申请号：US37972

    申请日：1993-03-29

    申请人： Gilbert Lassalle ,  Thomas Purcell ,  Daniel Galtier ,  Paul H. Williams ,  Frederic Galli

    发明人： Gilbert Lassalle ,  Thomas Purcell ,  Daniel Galtier ,  Paul H. Williams ,  Frederic Galli

    IPC分类号： A61K31/415 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/47 ,  A61P7/02 ,  C07D233/54 ,  C07D233/64 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07K5/078 ,  C07D403/14

    CPC分类号： C07D233/64 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07K5/06139

    摘要： Compounds of formula (I) ##STR1## wherein R represents a ##STR2## group in which R.sub.2 is a hydrogen atom, a (C.sub.1 -C.sub.4)alkoxycarbonyl group, a carboxylic group, a sodium carboxylate group, a --CH.sub.2 OR.sub.4 group R.sub.4 being a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group or a (C.sub.1 -C.sub.4)acyl group, an amide group of the formula --CONR.sub.5 R.sub.6, or a --CN.sub.4 R.sub.5 group, R.sub.5 being a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group and R.sub.6 being a hydrogen atom, a (C.sub.1 -C.sub.4)alkyl group, a hydroxy group or a (C.sub.1 -C.sub.4)alkoxy group, and R.sub.3 is a (C.sub.1 -C.sub.4)alkyl group,R.sub.1 represents either a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group,X represents either a sulphur atom, an oxygen atom or a methylene group, n=1 or 2 andAr represents either a naphthalen-1-yl group substituted by a di(C.sub.1 -C.sub.4)alkylamino group, or a 6,7-di(C.sub.1 -C.sub.4)alkoxynaphthalen-1-yl group, or a quinolin-8-yl group substituted at 3 by a (C.sub.1 -C.sub.4)alkyl group, or a 1,2,3,4-tetrahydroquinolin-8-yl group substituted at 3 by a (C.sub.1 -C.sub.4)alkyl, or a 1H-indazol-7-yl group and pharmaceutically acceptable organic or inorganic salts thereof.Application in therapy.

    摘要翻译： 式（I）化合物其中R表示其中R 2为氢原子，（C 1 -C 4）烷氧基羰基，羧基，羧酸钠基团，-CH 2 OR 4基团 R4是氢原子或（C1-C4）烷基或（C1-C4）酰基，式-CONR5R6的酰胺基或-CN4R5基，R5是氢原子或（C1-C4） ）烷基，R6为氢原子，（C1-C4）烷基，羟基或（C1-C4）烷氧基，R3为（C1-C4）烷基，R1为氢原子 或（C1-C4）烷基，X表示硫原子，氧原子或亚甲基，n = 1或2，Ar表示被二（C1-C4）烷基取代的萘-1-基， 烷基氨基或6,7-二（C1-C4）烷氧基萘-1-基或在3个被（C1-C4）烷基取代的喹啉-8-基）或1,2,3 （C 1 -C 4）烷基取代的4-四氢喹啉-8-基，或1H-吲唑-7-基和药学上可接受的组 其酸性或无机盐。 应用于治疗。

    Fast-cycling dwarf Bassica oleracea
    3.
    发明授权
    Fast-cycling dwarf Bassica oleracea 失效
    快速循环矮化Bassica oleracea

    公开(公告)号：US5107064A

    公开(公告)日：1992-04-21

    申请号：US111421

    申请日：1987-10-22

    申请人： Paul H. Williams ,  Alex W. May

    发明人： Paul H. Williams ,  Alex W. May

    IPC分类号： A01H5/00

    CPC分类号： A01H5/00

    摘要： This invention relates to a novel dwarf Brassica oleracea plant and a useful variety of rapid-cycling B. oleracea containing the single recessive mutant gene for the dwarf phenotype homozygously. The single gene (dwfl) is produced by mutagenesis and selection and is useful for producing novel types and varieties of dwarf Brassica plants for ornamental or agricultural purposes.

    摘要翻译： 本发明涉及一种新颖的矮化甘蓝植物，以及含有矮秆表型纯合的单一隐性突变基因的快速循环甘蓝的有用品种。 单一基因（dwfl）通过诱变和选择产生，可用于生产用于观赏或农业目的的矮化芸苔属植物的新型和品种。

    GARMENT COMPRISING A DETACHABLE AND EXCHANGEABLE FASHION STRIP
    5.
    发明申请
    GARMENT COMPRISING A DETACHABLE AND EXCHANGEABLE FASHION STRIP 审中-公开

    公开(公告)号：US20190116899A1

    公开(公告)日：2019-04-25

    申请号：US15755381

    申请日：2016-06-22

    申请人： Paul H. Williams ,  Silas H. Williams

    发明人： Paul H. Williams ,  Silas H. Williams

    IPC分类号： A41D27/08 ,  A41D1/06 ,  A41D1/02 ,  A41D27/10 ,  A41D15/00

    摘要： A garment incorporates a detachable garment strip. The garment has a first series of releasable fasteners attached to a garment part, and a second series of releasable fasteners attached to the garment part and spaced apart from the first series of releasable fasteners. The detachable garment strip is designed to overlie the garment part between the first and second series of releasable fasteners. The garment strip has first and second strip edges, a third series of releasable fasteners attached along the first strip edge, and a fourth series of releasable fasteners attached along the second strip edge.

    Valve to shaft assembly
    6.
    发明申请
    Valve to shaft assembly 审中-公开
    阀轴组装

    公开(公告)号：US20090001308A1

    公开(公告)日：2009-01-01

    申请号：US11821974

    申请日：2007-06-26

    申请人： Dominic N. Dalo ,  David C. Shuler ,  Frank A. Nicholas ,  David A. Chinnici ,  Paul H. Williams ,  Edward A. Cary

    发明人： Dominic N. Dalo ,  David C. Shuler ,  Frank A. Nicholas ,  David A. Chinnici ,  Paul H. Williams ,  Edward A. Cary

    IPC分类号： F16K1/22

    CPC分类号： F16K1/223 ,  F02B31/06 ,  F02D9/106 ,  F02D9/1095 ,  Y02T10/146

    摘要： A valve to shaft assembly includes a butterfly-type valve, a pair of bushings receiving the valve and holding the valve in axial position within a housing, and a shaft engaging the valve and the bushings and rotating the bushings in the housing. The bushings include features to hold the valve in position in the bore prior to assembly of the valve and, furthermore, act as rotating bearing surfaces for the valve. The valve to shaft assembly process may be simplified, especially where multiple valves are assembled to a single common drive shaft, such as in a port face charge motion control valve. Furthermore, the valve to shaft assembly provides an axial degree of freedom between valve, drive shaft, and bore, which allows the valve to float on the axis of the drive shaft, to facilitate self centering of the valve in the valve housing.

    摘要翻译： 阀到轴组件包括蝶形阀，一对接收阀并且将阀保持在壳体内的轴向位置的衬套，以及接合阀和衬套的轴并且将衬套旋转到壳体中。 衬套包括在组装阀门之前将阀保持在孔中的位置的特征，此外，还用作用于阀的旋转轴承表面。 可以简化阀到轴组装过程，特别是在多个阀组装到单个公共驱动轴（诸如端口面充气运动控制阀）中的情况下。 此外，阀到轴组件提供阀，驱动轴和孔之间的轴向自由度，其允许阀在驱动轴的轴线上浮动，以便于阀在阀壳中的自对中。

    Method and apparatus for assembling a vane-type valve
    7.
    发明授权
    Method and apparatus for assembling a vane-type valve 失效
    用于组装叶片式阀的方法和装置

    公开(公告)号：US07118092B2

    公开(公告)日：2006-10-10

    申请号：US11074960

    申请日：2005-03-08

    申请人： Frank A. Nicholas ,  Ashish Singh ,  Curtis D. Lamb ,  Paul H. Williams

    发明人： Frank A. Nicholas ,  Ashish Singh ,  Curtis D. Lamb ,  Paul H. Williams

    IPC分类号： F16K1/22

    CPC分类号： F16K1/22 ,  F16K27/0218 ,  Y10T137/0525 ,  Y10T137/6048

    摘要： A vane-type throttle valve assembly including a body having a passage therethrough and a pivotable shaft transverse of the passage and supporting a vane for variably restricting the flow of material through the passage. The shaft is disposed in opposing bores in the valve body. Each bore includes an access slot. The valve is assembled by inserting an integrated shaft and vane into the passage, engaging the ends of the shaft into the access slots, and translating the shaft ends in the access slots until the ends of the shaft are positioned in the bores. The shaft is retained in the bores by bushings inserted from outside the valve body. In a currently preferred embodiment, the access slots are formed over an angle from an axis of the bores, and the shaft ends are entered into the bores by rotating the shaft and vane about the passage axis.

    摘要翻译： 一种叶片式节气门组件，其包括具有通过其的通道的主体和横向于通道的可枢转轴，并且支撑叶片以可变地限制材料流过通道。 轴设置在阀体中的相对的孔中。 每个孔包括一个通道槽。 通过将一体的轴和叶片插入通道中来组装阀门，将轴的端部接合到进入狭槽中，并将轴端平移在进入狭槽中，直到轴的端部定位在孔中。 通过从阀体外部插入的衬套将轴保持在孔中。 在当前优选的实施例中，进入狭缝形成在与孔的轴线成一定角度上，并且轴端通过使轴和叶片围绕通道轴线旋转而进入孔中。

    Adjustable shoe
    8.
    发明授权
    Adjustable shoe 失效
    可调鞋

    公开(公告)号：US4969277A

    公开(公告)日：1990-11-13

    申请号：US935962

    申请日：1986-11-28

    申请人： Paul H. Williams

    发明人： Paul H. Williams

    IPC分类号： A43B3/26

    CPC分类号： A43B3/26

    摘要： An adjustable shoe to properly fit a wear's heel, midfoot, forefoot and toes. The lower edges of first and second body members are securely attached to the first and second side edges, respectively, of a sole member from a point conterminous with the midline of the toe end of the sole member to points on the first and second side edges, respectively, of the sole member spaced from the midline of the heel end of the sole. A first attachment structure adjustably secures the heel end portions of the body members relative to one another. A second attachment structure adjustably secures the forefoot portions of the body members relative to one another.

    摘要翻译： 一个可调节的鞋子，以适应佩戴的脚跟，中足，前脚掌和脚趾。 第一和第二主体构件的下边缘分别从与鞋底构件的趾端的中线连续的点牢固地附接到鞋底构件的第一和第二侧边缘，以在第一和第二侧边缘上的点 分别与鞋底的鞋跟端的中线间隔开。 第一附接结构可调节地相对于彼此固定身体构件的后跟端部。 第二附接结构可相对于彼此可调节地固定身体构件的前脚部分。

    Educational kit for fast cycling plants
    10.
    发明授权
    Educational kit for fast cycling plants 失效
    快速骑自行车的教育套件

    公开(公告)号：US4950166A

    公开(公告)日：1990-08-21

    申请号：US323209

    申请日：1989-03-13

    申请人： Paul H. Williams

    发明人： Paul H. Williams

    IPC分类号： G09B23/00 ,  G09B23/38

    CPC分类号： G09B23/38 ,  G09B23/00

    摘要： An educational kit for the classroom study of plants including a compact plant growth environment and a seed of fast-cycling Brassica plants. The fast-cycling plants grow in compact areas and have generation cycle times of sixty days or less making them convenient for classroom study. Various experiments on plant growth, physiology and genetics can be performed with the kits.

    摘要翻译： 一种用于植物课堂学习的教学套件，包括紧凑的植物生长环境和快速芸苔属植物的种子。 快速循环工厂在紧凑的地区生长，发电周期为六十天以内，方便课堂学习。 可以使用试剂盒进行植物生长，生理和遗传学的各种实验。