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公开(公告)号：US4260610A
公开(公告)日：1981-04-07
申请号：US957659
申请日：1978-11-03
IPC分类号： C07D409/12 , A61K31/495 , A61K31/505 , A61P9/08 , A61P9/12 , A61P25/00 , A61P29/00 , C07D327/00 , C07D327/04 , C07D411/12 , C07D417/12 , C07D411/14 , C07D417/14
CPC分类号： C07D327/04
摘要： Disubstituted piperazines of the formula: ##STR1## in which: n is 1 or 2,X is oxygen and Y is sulfur or sulfonyl or X and Y are both sulfur or sulfonyl, andHet is a 5- or 6-membered heterocyclic radical having from 1 to 3 hetero atoms inclusive selected from nitrogen and sulfur and optionally substituted by one or more alkyl each having from 1 to 5 carbon atoms inclusive.These compounds may be used as medicines, especially in the treatment of central nervous system disorders and Parkinson's disease.
摘要翻译： 下式的二取代哌嗪：其中：n为1或2，X为氧，Y为硫或磺酰基或X和Y均为硫或磺酰基，Het为具有5或6元杂环基， 包括选自氮和硫的1至3个杂原子，并且任选被一个或多个包含1至5个碳原子的烷基取代。 这些化合物可以用作药物，特别是用于治疗中枢神经系统障碍和帕金森病。
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公开(公告)号：US4010267A
公开(公告)日：1977-03-01
申请号：US562226
申请日：1975-03-26
IPC分类号： A61K31/495 , A61P9/08 , A61P25/26 , C07D317/46 , C07D317/72 , C07D405/12 , C07D417/12 , C07D295/08
CPC分类号： C07D317/72 , C07D317/46 , Y10S514/929
摘要： Benzodioxole compounds of the formula: vasodilator ##STR1## WHEREIN R.sub.1 is hydrogen, lower alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl,R.sub.2 is lower-alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl, orR.sub.1 + r.sub.2 are --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.6 -- andHet is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinazolinyl, 1,3,5 triazinyl or 1,3-thiazolyl, each being optionally substituted by lower-alkyl, lower-alkoxy, hydroxyl or phenyl.These compounds are used as medicines especially as peripheral vasocilator agent and central nervous system stimulant.
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公开(公告)号：US4177272A
公开(公告)日：1979-12-04
申请号：US864204
申请日：1977-12-27
IPC分类号： C07D403/04 , A61K31/495 , A61K31/496 , A61P9/00 , A61P9/12 , A61P25/00 , C07D249/14 , C07D271/06 , C07D271/07 , C07D285/08 , C07D285/12 , C07D285/135 , C07D317/00 , C07D319/00 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , A61K31/50
CPC分类号： C07D271/07 , C07D249/14 , C07D285/08 , C07D285/135
摘要： Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, .DELTA..sup.3 -chromenyl, thiochromanyl or .DELTA..sup.3 -thiochromenyl,X is nitrogen and simultaneously Y is oxygen or sulfur, orX is sulfur, imino (NH) or methylimino (N CH.sub.3) and simultaneously Y is nitrogen, andR is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl.These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.
摘要翻译： 下式的二取代哌嗪其中：苯并[b]呋喃基，苯并[b]噻吩基，苯并二恶唑基，苯并二氧杂环戊烷基，苯并二恶环庚烷基，香豆素基，苯并二氢吡喃基，DELTA 3-苯并二氢吡喃基， ，X是氮，同时Y是氧或硫，或X是硫，亚氨基（NH）或甲基亚氨基（N CH3），同时Y是氮，R是氢，低级烷基，苯基，卤代苯基，低级烷基苯基或低级 烷氧基苯基。 这些化合物具有有趣的药理和治疗特性，可用作药物，特别是用于治疗高血压，外周血管疾病和帕金森病。
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公开(公告)号：US4100286A
公开(公告)日：1978-07-11
申请号：US741740
申请日：1976-11-15
IPC分类号： A61K31/505 , A61K31/52 , A61P9/00 , A61P21/02 , A61P25/00 , A61P25/08 , C07D239/48 , C07D473/00 , C07D473/34 , C07D473/40 , C07D487/04
CPC分类号： C07D487/04 , C07D239/48 , C07D473/00 , C07D473/34 , C07D473/40
摘要： Heterocyclic compounds of the formula: ##STR1## WHEREIN ONE OF Y and Z is CH, the other being N, A is a straight or branched saturated hydrocarbon chain from C.sub.2 to C.sub.6 inclusive, X is chlorine, hydroxy, alkoxy or alkylthio each from C.sub.1 to C.sub.5 inclusive, R is hydrogen, alkyl, hydroxyalkyl or dihydroxyalkyl each from C.sub.1 to C.sub.3 inclusive, R' is halogen, alkyl or alkoxy each from C.sub.1 to C.sub.3 inclusive and n is 0, 1 or 2.These compounds, their optical isomers and their physiologically tolerable salts are used as medicines especially in the treatment of central nervous system disorders.
摘要翻译： 下式的杂环化合物：Y和Z之一为CH，另一个为N，A为C2至C6的直链或支链饱和烃链，其中X为氯，羟基，烷氧基或烷硫基，各自为C1 为C 5，R为氢，烷基，羟基烷基或二羟基烷基，各自为C 1〜C 3，其中R 1为卤素，烷基或烷氧基，各自为C 1〜C 3，其中n为0,1或2。
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公开(公告)号：US3954765A
公开(公告)日：1976-05-04
申请号：US512461
申请日：1974-10-07
IPC分类号： C07D417/12 , A61K31/495 , A61P9/08 , A61P9/12 , A61P25/00 , A61P25/04 , B01J23/00 , C07B61/00 , C07D295/04 , C07D311/04 , C07D417/14 , C07D295/12
CPC分类号： C07D417/14
摘要： Piperazine derivatives of the formula: ##SPC1##Wherein n is 0 or 1, X is oxygen or sulfur, R and R', which are the same or different, are hydrogen or lower alkyl and: ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicine especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and pain.
摘要翻译： 下式的哌嗪衍生物：
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公开(公告)号：US4112092A
公开(公告)日：1978-09-05
申请号：US785855
申请日：1977-04-08
IPC分类号： C07D277/20 , A61K31/54 , A61P9/08 , A61P9/10 , A61P25/00 , C07D277/42 , C07D417/04 , A61K31/495
CPC分类号： C07D417/04
摘要： Naphthyl derivatives of the formula: ##STR1## wherein: R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, andR.sub.2 and R.sub.3, which are the same or different, are hydrogen, lower alkyl or phenyl,Or R.sub.2 and R.sub.3 joined together are --CH .dbd. CH -- CH .dbd. CH--.These compounds are used as medicines, especially in the treatment of disorders of central nervous system (CNS), Parkinson's disease and cardiovascular disorders.
摘要翻译： 下式的萘衍生物：其中：
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7.发明授权N-Coumaranyl and chromanyl -methyl-or sulfur analogs thereof-N'- thiazolyl piperazines 失效N-香叶基和苯并二氢吡喃基 - 甲基或硫磺类似物-N {40-噻唑基哌嗪
公开(公告)号：US3944551A
公开(公告)日：1976-03-16
申请号：US454665
申请日：1974-03-25
IPC分类号： C07D307/79 , A61K31/495 , A61K31/50 , A61K31/505 , A61P9/08 , A61P9/12 , A61P25/08 , B01J23/00 , C07B61/00 , C07D213/74 , C07D295/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D417/14 , C07D295/12
CPC分类号： C07D409/06 , C07D417/14 , Y10S514/843 , Y10S514/929
摘要： Disubstituted piperazines of the formula: ##SPC1##Wherein:n is 1 or 2;X is oxygen or sulfur;R is hydrogen or lower alkyl;Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl, quinazolyl, thiazolyl or benzothiazolyl, each optionally substituted by one or more lower alkyl, lower alkoxy, phenyl, amino, mono or di-lower-alkylamino, or hydroxy, and, ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicines especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and as antipregnancy drugs.
摘要翻译： 下式的二取代哌嗪：
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8.发明授权Pharmaceutical compositions containing a gamma-resorcylic acid derivative in the treatment of thrombosis 失效含有γ-间苯二酚衍生物的治疗血栓形成的药物组合物
公开(公告)号：US4132787A
公开(公告)日：1979-01-02
申请号：US688533
申请日：1976-05-21
CPC分类号： A61K31/60 , Y10S514/824
摘要： Pharmaceutical compositions containing as active principle a .gamma.-resorcylic acid derivative of the formula: ##STR1## or a physiologically tolerable salt thereof. These pharmaceutical compositions are used especially in the treatment of thromboembolic diseases and arteriosclerosis.
摘要翻译： 作为活性成分的药物组合物含有下式的γ-反式间苯二甲酸衍生物或其生理上可耐受的盐。
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公开(公告)号：US3970663A
公开(公告)日：1976-07-20
申请号：US615452
申请日：1975-09-22
申请人： Gilbert Regnier , Roger Canevari , Xavier Pascaud
发明人： Gilbert Regnier , Roger Canevari , Xavier Pascaud
IPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D213/56
CPC分类号： C07D401/12 , C07D239/42 , C07D403/12 , Y10S514/926
摘要： Heterocyclic amides of the formula: ##EQU1## wherein: X is N or CH;n is O or 1 andR is ##EQU2## wherein: R.sub.1 is hydrogen or methyl, R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar - A- or ##EQU3## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methylenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.
摘要翻译： 式：CO-NH-（CH2）n-RH2N的杂环酰胺其中：
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公开(公告)号：US3970661A
公开(公告)日：1976-07-20
申请号：US465931
申请日：1974-05-01
申请人： Gilbert Regnier , Roger Canevari , Xavier Pascaud
发明人： Gilbert Regnier , Roger Canevari , Xavier Pascaud
IPC分类号： C07D213/81 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/455 , A61K31/505 , A61K31/535 , A61P1/04 , A61P25/00 , C07D213/82 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/14 , C07D213/75
CPC分类号： C07D213/82 , C07D239/42 , C07D401/12 , C07D403/12 , Y10S514/927
摘要： Heterocyclic amides of the formula: ##SPC1##Wherein:X is N or CH;n is O or 1 andR is ##EQU1## or ##SPC2##Wherein:R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar -- A-- or Ar ##EQU2## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methlenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.
摘要翻译： 下式的杂环酰胺：
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