公开(公告)号：US20240043427A1

公开(公告)日：2024-02-08

申请号：US17997594

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07K16/2827 ,  C07K16/2818 ,  A61K45/06

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US12110294B2

公开(公告)日：2024-10-08

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC classification number: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present disclosure provides pyrimidine dione compounds of Formula I






and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.

公开(公告)号：US20230039553A1

公开(公告)日：2023-02-09

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US20240279186A1

公开(公告)日：2024-08-22

申请号：US18428316

申请日：2024-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:






or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US11919869B2

公开(公告)日：2024-03-05

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20230183189A1

公开(公告)日：2023-06-15

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.