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    Cell penetrating peptides for intracellular delivery of molecules
    1.
    发明授权
    Cell penetrating peptides for intracellular delivery of molecules 有权
    细胞穿透肽用于分子的细胞内递送

    公开(公告)号：US07943581B2

    公开(公告)日：2011-05-17

    申请号：US12346000

    申请日：2008-12-30

    申请人： Gilles Divita ,  Frederic Heitz ,  Catherine May Morris ,  Gudrun Aldrian-Herrada

    发明人： Gilles Divita ,  Frederic Heitz ,  Catherine May Morris ,  Gudrun Aldrian-Herrada

    IPC分类号： A61K38/10 ,  A61K48/00 ,  A61K47/00

    CPC分类号： C07K14/00

    摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8(SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.

    摘要翻译： 本发明涉及包含由GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8（SEQ ID No：1）组成的氨基酸序列的细胞穿透肽，其中X1为A，L或G，X2为W或无，X3为R或K，X4为K， L或S，X 5为L或K，X 6为R或W，X 7为K或S，X 8为A，V或Q，X 9为W，F或Y.这些CPP可用作递送核酸 酸和/或蛋白质和/或肽在体外或体内。

    Cell penetrating peptides for intracellular delivery of molecules
    2.
    发明授权
    Cell penetrating peptides for intracellular delivery of molecules 有权
    细胞穿透肽用于分子的细胞内递送

    公开(公告)号：US07579318B2

    公开(公告)日：2009-08-25

    申请号：US11294421

    申请日：2005-12-06

    申请人： Gilles Divita ,  Frédéric Heitz ,  Catherine May Morris ,  Gudrun Aldrian-Herrada

    发明人： Gilles Divita ,  Frédéric Heitz ,  Catherine May Morris ,  Gudrun Aldrian-Herrada

    IPC分类号： A61K38/00

    CPC分类号： C07K14/00

    摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.

    摘要翻译： 本发明涉及包含由GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8（SEQ ID No：1）组成的氨基酸序列的细胞穿透肽，其中X1为A，L或G，X2为W或无，X3为R或K，X4为K， L或S，X 5为L或K，X 6为R或W，X 7为K或S，X 8为A，V或Q，X 9为W，F或Y.这些CPP可用作递送核酸 酸和/或蛋白质和/或肽在体外或体内。