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    Stents made of biodegradable and non-biodegradable materials
    1.
    发明申请
    Stents made of biodegradable and non-biodegradable materials 审中-公开
    可生物降解和不可生物降解材料制成的支架

    公开(公告)号：US20070219626A1

    公开(公告)日：2007-09-20

    申请号：US11717797

    申请日：2007-03-13

    申请人： Giovanni Rolando ,  Maria Curcio ,  Andrea Grignani ,  Paolo Gaschino

    发明人： Giovanni Rolando ,  Maria Curcio ,  Andrea Grignani ,  Paolo Gaschino

    IPC分类号： A61F2/90

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/825 ,  A61F2002/91541 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0031

    摘要： A stent comprising a plurality of annular elements aligned in the longitudinal direction of extension of the stent and selectively expandable between a radially-contracted condition and a radially-expanded condition as well as a series of connecting elements that extend in the longitudinal direction of extension of the stent to connect the annular elements. The annular elements and the connecting elements are made, respectively, of non-biodegradable material and of biodegradable material. The structure of the stent thus comprises a part of non-biodegradable material, destined to remain long-term at the site of implantation, and a part of biodegradable material, destined to disappear within a longer or shorter period after implantation.

    摘要翻译： 一种支架，其包括沿支架的延伸方向的长度方向排列的多个环形元件，并且可选地在径向收缩状态和径向扩张状态之间扩张，以及一系列连接元件， 支架连接环形元件。 环形元件和连接元件分别由不可生物降解的材料和可生物降解材料制成。 因此，支架的结构包括一部分不可生物降解的材料，注定在植入位置长期保留，并且一部分可生物降解的材料注定在植入后较长或较短的时期内消失。

    Actuating device for catheters
    3.
    发明授权
    Actuating device for catheters 有权
    导管用驱动装置

    公开(公告)号：US07278998B2

    公开(公告)日：2007-10-09

    申请号：US10761950

    申请日：2004-01-21

    申请人： Paolo Gaschino ,  Laura Ghione ,  Maria Curcio ,  Giovanni Rolando

    发明人： Paolo Gaschino ,  Laura Ghione ,  Maria Curcio ,  Giovanni Rolando

    IPC分类号： A61F2/04

    CPC分类号： A61F2/95 ,  A61F2002/9517 ,  A61M25/0113

    摘要： An actuating device for a catheter comprising at least one first part and one second part, which are able to more relative to each other, the actuating device comprising: (i) a slide which can be connected to one of said first part and said second part of the catheter; (ii) a slider, which can be actuated for moving said slide and moving said first part and said second part relative to each other; and (iii) a speed-change mechanism, which is set between said slider and said slide.

    摘要翻译： 一种用于导管的致动装置，包括至少一个能够相对于彼此相对的第一部分和一个第二部分，所述致动装置包括：（i）滑动件，其可以连接到所述第一部分和所述第二部分之一 部分导管; （ii）滑块，其可以被致动以移动所述滑块并使所述第一部件和所述第二部件相对于彼此移动; 和（iii）设置在所述滑块和所述滑块之间的变速机构。

    Method and device for cellular therapy
    4.
    发明申请
    Method and device for cellular therapy 审中-公开
    细胞治疗的方法和装置

    公开(公告)号：US20070065418A1

    公开(公告)日：2007-03-22

    申请号：US11524087

    申请日：2006-09-20

    申请人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Andrea Grignani

    发明人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Andrea Grignani

    IPC分类号： A61M31/00 ,  A61M37/00 ,  A61K35/12

    CPC分类号： A61M25/1011 ,  A61K35/12 ,  A61M25/1027 ,  A61M2025/1086 ,  A61M2025/1088

    摘要： A device and method for performing a therapeutic treatment at a treatment site in a patient's vessel, the device configured to be introduced by means of a catheter, the device including an expandable portion capable of being expanded between a contracted position and a deployed position at the treatment site, such as to achieve an angioplasty treatment at the site, and a conveyor portion capable of receiving cells for cellular therapy and delivering the cells to the treatment site such that the angioplasty and cellular therapy procedures are performed substantially simultaneously.

    摘要翻译： 一种用于在患者血管的治疗部位进行治疗性处置的装置和方法，所述装置被构造成通过导管引入，所述装置包括能够在收缩位置和展开位置之间扩张的可扩张部分 治疗部位，例如在现场实现血管成形术治疗，以及能够接收细胞用于细胞治疗并将细胞递送到治疗部位的输送部分，使得血管成形术和细胞治疗程序基本上同时进行。

    Stents for angioplasty
    5.
    发明授权
    Stents for angioplasty 有权
    血管成形术支架

    公开(公告)号：US06451049B2

    公开(公告)日：2002-09-17

    申请号：US09410303

    申请日：1999-10-01

    申请人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Paolo Gaschino

    发明人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Paolo Gaschino

    IPC分类号： A61F206

    CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91541 ,  A61F2002/9155 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0036

    摘要： This invention is a stent having a substantially tubular body defining a longitudinal axis comprising first and second adjacent annular segments, each segment defining a substantially sinusoidal shape having a plurality of peaks and valleys, the peaks of the first segment extending toward the second segment and being aligned longitudinally with the valleys of the second segment. The stent has a plurality of bridge elements having a U-shaped portion between first and second connector arms, the first connector arm of one bridge element being connected between a first peak and a first valley of the first segment and the second connector arm being connected between a first peak and a first valley of the second segment in a manner such that the U-shaped portion extends in the direction of the first peak of the first segment and the first valley of the second segment. The bridge elements may be connected to the segments at points spaced 360° apart along the sinusoidal shape of the segments. The segments and bridge elements are configured such that when compression, flexure, and torsion forces are applied to the stent they generate first maximum stress regions, second maximum stress regions and third maximum stress regions which do not overlap.

    摘要翻译： 本发明是一种支架，其具有限定纵向轴线的基本上管状的主体，该纵向轴线包括第一和第二相邻的环形段，每个段限定具有多个峰和谷的基本正弦形状，第一段的峰向第二段延伸， 与第二段的谷部纵向对齐。 支架具有在第一和第二连接器臂之间具有U形部分的多个桥接元件，一个桥接元件的第一连接臂连接在第一段的第一峰与第一谷之间，第二连接臂连接 在第二段的第一峰和第一谷之间以使得U形部分沿第一段的第一峰和第二段的第一谷的方向延伸的方式。 桥接元件可以沿着分段的正弦形状间隔360°的点处连接到段。 段和桥元件构造成使得当压缩，弯曲和扭转力施加到支架时，它们产生不重叠的第一最大应力区域，第二最大应力区域和第三最大应力区域。

    Angioplasty stents
    7.
    发明授权
    Angioplasty stents 有权
    血管成形术支架

    公开(公告)号：US06699281B2

    公开(公告)日：2004-03-02

    申请号：US10198054

    申请日：2002-07-18

    申请人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Paolo Gaschino

    发明人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Paolo Gaschino

    IPC分类号： A61F206

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/9155 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0068

    摘要： A stent for use at an implant site in a vessel having recesses containing one or more active agents. The stent is a tubular body having a plurality of sinusoidal shaped annular elements and connection elements. The recesses are formed so as to leave substantially unaltered the bending moments of these elements. The recesses may be continuous or discontinuous and may be distributed uniformly or nonuniformly.

    摘要翻译： 一种在具有含有一种或多种活性剂的凹陷的容器中的植入部位处使用的支架。 支架是具有多个正弦形环形元件和连接元件的管状体。 凹部形成为使得这些元件的弯矩基本上不变。 凹部可以是连续的或不连续的，并且可以均匀地或不均匀地分布。

    System for in situ positioning of cardiac valve prostheses without occluding blood flow
    10.
    发明授权
    System for in situ positioning of cardiac valve prostheses without occluding blood flow 有权
    用于心脏瓣膜假体原位定位而不堵塞血流的系统

    公开(公告)号：US08057539B2

    公开(公告)日：2011-11-15

    申请号：US11612974

    申请日：2006-12-19

    申请人： Laura Ghione ,  Giovanni Righini ,  Eric Manasse ,  Giovanni Rolando ,  Paolo Gaschino ,  Dong Ik Shin

    发明人： Laura Ghione ,  Giovanni Righini ,  Eric Manasse ,  Giovanni Rolando ,  Paolo Gaschino ,  Dong Ik Shin

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2436 ,  A61F2/2412

    摘要： An instrument for positioning a cardiac valve prosthesis in a vessel includes a wire element to slidingly guide the valve prosthesis towards an implantation site and an expandable element coupled to the wire element. The expandable element is expandable in the vessel to position the wire element in association with the implantation site. A method for positioning a cardiac valve prosthesis includes securing a delivery instrument at an appropriate location at the implantation site and delivering the valve prosthesis to the implantation site using the delivery instrument.

    摘要翻译： 用于将心脏瓣膜假体定位在血管中的仪器包括用于将瓣膜假体滑动地引向植入部位的线元件和联接到线元件的可扩张元件。 可膨胀元件在容器中是可扩张的，以便与植入部位相关联地定位线元件。 用于定位心脏瓣膜假体的方法包括将输送器械固定在植入部位的适当位置，并使用输送器械将瓣膜假体输送到植入部位。