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公开(公告)号：US20070219626A1
公开(公告)日：2007-09-20
申请号：US11717797
申请日：2007-03-13
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558 , A61F2230/0054 , A61F2250/0031
摘要： A stent comprising a plurality of annular elements aligned in the longitudinal direction of extension of the stent and selectively expandable between a radially-contracted condition and a radially-expanded condition as well as a series of connecting elements that extend in the longitudinal direction of extension of the stent to connect the annular elements. The annular elements and the connecting elements are made, respectively, of non-biodegradable material and of biodegradable material. The structure of the stent thus comprises a part of non-biodegradable material, destined to remain long-term at the site of implantation, and a part of biodegradable material, destined to disappear within a longer or shorter period after implantation.
摘要翻译： 一种支架，其包括沿支架的延伸方向的长度方向排列的多个环形元件，并且可选地在径向收缩状态和径向扩张状态之间扩张，以及一系列连接元件， 支架连接环形元件。 环形元件和连接元件分别由不可生物降解的材料和可生物降解材料制成。 因此，支架的结构包括一部分不可生物降解的材料，注定在植入位置长期保留，并且一部分可生物降解的材料注定在植入后较长或较短的时期内消失。
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公开(公告)号：US20070065418A1
公开(公告)日：2007-03-22
申请号：US11524087
申请日：2006-09-20
CPC分类号： A61M25/1011 , A61K35/12 , A61M25/1027 , A61M2025/1086 , A61M2025/1088
摘要： A device and method for performing a therapeutic treatment at a treatment site in a patient's vessel, the device configured to be introduced by means of a catheter, the device including an expandable portion capable of being expanded between a contracted position and a deployed position at the treatment site, such as to achieve an angioplasty treatment at the site, and a conveyor portion capable of receiving cells for cellular therapy and delivering the cells to the treatment site such that the angioplasty and cellular therapy procedures are performed substantially simultaneously.
摘要翻译： 一种用于在患者血管的治疗部位进行治疗性处置的装置和方法，所述装置被构造成通过导管引入，所述装置包括能够在收缩位置和展开位置之间扩张的可扩张部分 治疗部位，例如在现场实现血管成形术治疗，以及能够接收细胞用于细胞治疗并将细胞递送到治疗部位的输送部分，使得血管成形术和细胞治疗程序基本上同时进行。
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公开(公告)号：US06451049B2
公开(公告)日：2002-09-17
申请号：US09410303
申请日：1999-10-01
申请人： Franco Vallana , Giovanni Rolando , Maria Curcio , Paolo Gaschino
发明人： Franco Vallana , Giovanni Rolando , Maria Curcio , Paolo Gaschino
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2002/9155 , A61F2002/91583 , A61F2230/0054 , A61F2250/0036
摘要： This invention is a stent having a substantially tubular body defining a longitudinal axis comprising first and second adjacent annular segments, each segment defining a substantially sinusoidal shape having a plurality of peaks and valleys, the peaks of the first segment extending toward the second segment and being aligned longitudinally with the valleys of the second segment. The stent has a plurality of bridge elements having a U-shaped portion between first and second connector arms, the first connector arm of one bridge element being connected between a first peak and a first valley of the first segment and the second connector arm being connected between a first peak and a first valley of the second segment in a manner such that the U-shaped portion extends in the direction of the first peak of the first segment and the first valley of the second segment. The bridge elements may be connected to the segments at points spaced 360° apart along the sinusoidal shape of the segments. The segments and bridge elements are configured such that when compression, flexure, and torsion forces are applied to the stent they generate first maximum stress regions, second maximum stress regions and third maximum stress regions which do not overlap.
摘要翻译： 本发明是一种支架，其具有限定纵向轴线的基本上管状的主体，该纵向轴线包括第一和第二相邻的环形段，每个段限定具有多个峰和谷的基本正弦形状，第一段的峰向第二段延伸， 与第二段的谷部纵向对齐。 支架具有在第一和第二连接器臂之间具有U形部分的多个桥接元件，一个桥接元件的第一连接臂连接在第一段的第一峰与第一谷之间，第二连接臂连接 在第二段的第一峰和第一谷之间以使得U形部分沿第一段的第一峰和第二段的第一谷的方向延伸的方式。 桥接元件可以沿着分段的正弦形状间隔360°的点处连接到段。 段和桥元件构造成使得当压缩，弯曲和扭转力施加到支架时，它们产生不重叠的第一最大应力区域，第二最大应力区域和第三最大应力区域。
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公开(公告)号：US07344563B2
公开(公告)日：2008-03-18
申请号：US10790649
申请日：2004-03-01
申请人： Franco Vallana , Giovanni Rolando , Maria Curcio , Paolo Gaschino
发明人： Franco Vallana , Giovanni Rolando , Maria Curcio , Paolo Gaschino
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/9155 , A61F2002/91583 , A61F2230/0054 , A61F2250/0068
摘要： A stent for use at an implant site in a vessel having recesses containing one or more active agents. The stent is a tubular body having a plurality of sinusoidal shaped annular elements and connection elements. The recesses are formed so as to leave substantially unaltered the bending moments of these elements. The recesses may be continuous or discontinuous and may be distributed uniformly or nonuniformly.
摘要翻译： 一种在具有含有一种或多种活性剂的凹陷的容器中的植入部位处使用的支架。 支架是具有多个正弦形环形元件和连接元件的管状体。 凹部形成为使得这些元件的弯矩基本上不变。 凹部可以是连续的或不连续的，并且可以均匀地或不均匀地分布。
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公开(公告)号：US07278998B2
公开(公告)日：2007-10-09
申请号：US10761950
申请日：2004-01-21
申请人： Paolo Gaschino , Laura Ghione , Maria Curcio , Giovanni Rolando
发明人： Paolo Gaschino , Laura Ghione , Maria Curcio , Giovanni Rolando
IPC分类号： A61F2/04
CPC分类号： A61F2/95 , A61F2002/9517 , A61M25/0113
摘要： An actuating device for a catheter comprising at least one first part and one second part, which are able to more relative to each other, the actuating device comprising: (i) a slide which can be connected to one of said first part and said second part of the catheter; (ii) a slider, which can be actuated for moving said slide and moving said first part and said second part relative to each other; and (iii) a speed-change mechanism, which is set between said slider and said slide.
摘要翻译： 一种用于导管的致动装置，包括至少一个能够相对于彼此相对的第一部分和一个第二部分，所述致动装置包括：（i）滑动件，其可以连接到所述第一部分和所述第二部分之一 部分导管; （ii）滑块，其可以被致动以移动所述滑块并使所述第一部件和所述第二部件相对于彼此移动; 和（iii）设置在所述滑块和所述滑块之间的变速机构。
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公开(公告)号：US20120323312A1
公开(公告)日：2012-12-20
申请号：US13596653
申请日：2012-08-28
CPC分类号： A61F2/86 , A61F2/91 , A61F2250/0068
摘要： The present invention provides a stent for implantation at a site within a human or animal body comprising: an expandable body having an inner surface and an outer surface; and treatment agents applied to the outer surface of the expandable body, the treatment agents comprising a combination of Paclitaxel and FK506 or their derivatives or analogues.
摘要翻译： 本发明提供一种用于植入人体或动物体内的部位的支架，包括：具有内表面和外表面的可扩张体; 以及施加到可膨胀体的外表面的处理剂，所述处理剂包含紫杉醇和FK506或其衍生物或类似物的组合。
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公开(公告)号：US06699281B2
公开(公告)日：2004-03-02
申请号：US10198054
申请日：2002-07-18
申请人： Franco Vallana , Giovanni Rolando , Maria Curcio , Paolo Gaschino
发明人： Franco Vallana , Giovanni Rolando , Maria Curcio , Paolo Gaschino
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/9155 , A61F2002/91583 , A61F2230/0054 , A61F2250/0068
摘要： A stent for use at an implant site in a vessel having recesses containing one or more active agents. The stent is a tubular body having a plurality of sinusoidal shaped annular elements and connection elements. The recesses are formed so as to leave substantially unaltered the bending moments of these elements. The recesses may be continuous or discontinuous and may be distributed uniformly or nonuniformly.
摘要翻译： 一种在具有含有一种或多种活性剂的凹陷的容器中的植入部位处使用的支架。 支架是具有多个正弦形环形元件和连接元件的管状体。 凹部形成为使得这些元件的弯矩基本上不变。 凹部可以是连续的或不连续的，并且可以均匀地或不均匀地分布。
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公开(公告)号：US20050209681A1
公开(公告)日：2005-09-22
申请号：US11051645
申请日：2005-02-04
CPC分类号： A61F2/86 , A61F2/91 , A61F2250/0068
摘要： The present invention provides a stent for implantation at a site within a human or animal body comprising: an expandable body having an inner surface and an outer surface; and treatment agents applied to the outer surface of the expandable body, the treatment agents comprising a combination of Paclitaxel and FK506 or their derivatives or analogues.
摘要翻译： 本发明提供一种用于植入人体或动物体内的部位的支架，包括：具有内表面和外表面的可扩张体; 以及施加到可膨胀体的外表面的处理剂，所述处理剂包含紫杉醇和FK506或其衍生物或类似物的组合。
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公开(公告)号：US20060030937A1
公开(公告)日：2006-02-09
申请号：US11249970
申请日：2005-10-13
IPC分类号： A61F2/06
CPC分类号： A61K9/0024 , A61F2250/0068 , A61L31/16 , A61L2300/624
摘要： A carrier for delivering at least one active principle at an intraluminal site. The carrier includes a carrier body, such as a stent. The carrier body is provided with one or more reservoirs. The reservoirs contain nanoparticles which convey at least one active principle. The nanoparticles also comprise a substance having characteristics of preferential affinity attraction to a desired region at the intraluminal site. The nanoparticles can migrate toward the preferred region.
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10.发明授权公开(公告)号：US09011898B2
公开(公告)日：2015-04-21
申请号：US13825074
申请日：2011-09-19
CPC分类号： A61L31/16 , A61L27/54 , A61L29/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/432 , A61L2300/602
摘要： Composition for delivery of at least one active principle at the implantation site of an implant device, including: at least one active principle, and at least a first excipient combined with the at least one active principle, wherein the at least a first excipient is selected among fatty acids with a linear or branched, saturated chain, including a number of carbon atoms between 14 and 36.
摘要翻译： 用于在植入装置的植入部位输送至少一种活性成分的组合物，包括：至少一种活性成分，和至少一种与所述至少一种活性成分组合的第一赋形剂，其中至少选择第一赋形剂 在具有直链或支链饱和链的脂肪酸中，包括14至36之间的多个碳原子。
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