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公开(公告)号：US20070065418A1
公开(公告)日：2007-03-22
申请号：US11524087
申请日：2006-09-20
CPC分类号： A61M25/1011 , A61K35/12 , A61M25/1027 , A61M2025/1086 , A61M2025/1088
摘要： A device and method for performing a therapeutic treatment at a treatment site in a patient's vessel, the device configured to be introduced by means of a catheter, the device including an expandable portion capable of being expanded between a contracted position and a deployed position at the treatment site, such as to achieve an angioplasty treatment at the site, and a conveyor portion capable of receiving cells for cellular therapy and delivering the cells to the treatment site such that the angioplasty and cellular therapy procedures are performed substantially simultaneously.
摘要翻译： 一种用于在患者血管的治疗部位进行治疗性处置的装置和方法，所述装置被构造成通过导管引入，所述装置包括能够在收缩位置和展开位置之间扩张的可扩张部分 治疗部位，例如在现场实现血管成形术治疗，以及能够接收细胞用于细胞治疗并将细胞递送到治疗部位的输送部分，使得血管成形术和细胞治疗程序基本上同时进行。
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公开(公告)号：US20060030937A1
公开(公告)日：2006-02-09
申请号：US11249970
申请日：2005-10-13
IPC分类号： A61F2/06
CPC分类号： A61K9/0024 , A61F2250/0068 , A61L31/16 , A61L2300/624
摘要： A carrier for delivering at least one active principle at an intraluminal site. The carrier includes a carrier body, such as a stent. The carrier body is provided with one or more reservoirs. The reservoirs contain nanoparticles which convey at least one active principle. The nanoparticles also comprise a substance having characteristics of preferential affinity attraction to a desired region at the intraluminal site. The nanoparticles can migrate toward the preferred region.
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3.发明申请公开(公告)号：US20110066228A1
公开(公告)日：2011-03-17
申请号：US12951712
申请日：2010-11-22
IPC分类号： A61F2/82
CPC分类号： A61K9/0024 , A61F2250/0068 , A61L31/16 , A61L2300/624
摘要： A carrier for delivering at least one active principle at an intraluminal site. The carrier includes a carrier body, such as a stent. The carrier body is provided with one or more reservoirs. The reservoirs contain nanoparticles which convey at least one active principle. The nanoparticles also comprise a substance having characteristics of preferential affinity attraction to a desired region at the intraluminal site. The nanoparticles can migrate toward the preferred region.
摘要翻译： 用于在管腔内部位输送至少一种活性成分的载体。 载体包括载体如支架。 载体主体设置有一个或多个储存器。 储层包含至少一种有效原理的纳米颗粒。 纳米颗粒还包含具有对腔内部位所需区域的优先亲和力吸引特性的物质。 纳米颗粒可以朝向优选区域迁移。
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公开(公告)号：US20120323312A1
公开(公告)日：2012-12-20
申请号：US13596653
申请日：2012-08-28
CPC分类号： A61F2/86 , A61F2/91 , A61F2250/0068
摘要： The present invention provides a stent for implantation at a site within a human or animal body comprising: an expandable body having an inner surface and an outer surface; and treatment agents applied to the outer surface of the expandable body, the treatment agents comprising a combination of Paclitaxel and FK506 or their derivatives or analogues.
摘要翻译： 本发明提供一种用于植入人体或动物体内的部位的支架，包括：具有内表面和外表面的可扩张体; 以及施加到可膨胀体的外表面的处理剂，所述处理剂包含紫杉醇和FK506或其衍生物或类似物的组合。
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公开(公告)号：US20070219626A1
公开(公告)日：2007-09-20
申请号：US11717797
申请日：2007-03-13
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558 , A61F2230/0054 , A61F2250/0031
摘要： A stent comprising a plurality of annular elements aligned in the longitudinal direction of extension of the stent and selectively expandable between a radially-contracted condition and a radially-expanded condition as well as a series of connecting elements that extend in the longitudinal direction of extension of the stent to connect the annular elements. The annular elements and the connecting elements are made, respectively, of non-biodegradable material and of biodegradable material. The structure of the stent thus comprises a part of non-biodegradable material, destined to remain long-term at the site of implantation, and a part of biodegradable material, destined to disappear within a longer or shorter period after implantation.
摘要翻译： 一种支架，其包括沿支架的延伸方向的长度方向排列的多个环形元件，并且可选地在径向收缩状态和径向扩张状态之间扩张，以及一系列连接元件， 支架连接环形元件。 环形元件和连接元件分别由不可生物降解的材料和可生物降解材料制成。 因此，支架的结构包括一部分不可生物降解的材料，注定在植入位置长期保留，并且一部分可生物降解的材料注定在植入后较长或较短的时期内消失。
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公开(公告)号：US20050209681A1
公开(公告)日：2005-09-22
申请号：US11051645
申请日：2005-02-04
CPC分类号： A61F2/86 , A61F2/91 , A61F2250/0068
摘要： The present invention provides a stent for implantation at a site within a human or animal body comprising: an expandable body having an inner surface and an outer surface; and treatment agents applied to the outer surface of the expandable body, the treatment agents comprising a combination of Paclitaxel and FK506 or their derivatives or analogues.
摘要翻译： 本发明提供一种用于植入人体或动物体内的部位的支架，包括：具有内表面和外表面的可扩张体; 以及施加到可膨胀体的外表面的处理剂，所述处理剂包含紫杉醇和FK506或其衍生物或类似物的组合。
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公开(公告)号：US20130280315A1
公开(公告)日：2013-10-24
申请号：US13825074
申请日：2011-09-19
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61L27/54 , A61L29/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/432 , A61L2300/602
摘要： Composition for delivery of at least one active principle at the implantation site of an implant device, including: at least one active principle, and at least a first excipient combined with the at least one active principle, wherein the at least a first excipient is selected among fatty acids with a linear or branched, saturated chain, including a number of carbon atoms between 14 and 36.
摘要翻译： 用于在植入装置的植入部位输送至少一种活性成分的组合物，包括：至少一种活性成分，和至少一种与所述至少一种活性成分组合的第一赋形剂，其中至少选择第一赋形剂 在具有直链或支链饱和链的脂肪酸中，包括14至36之间的多个碳原子。
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8.发明授权公开(公告)号：US09011898B2
公开(公告)日：2015-04-21
申请号：US13825074
申请日：2011-09-19
CPC分类号： A61L31/16 , A61L27/54 , A61L29/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/432 , A61L2300/602
摘要： Composition for delivery of at least one active principle at the implantation site of an implant device, including: at least one active principle, and at least a first excipient combined with the at least one active principle, wherein the at least a first excipient is selected among fatty acids with a linear or branched, saturated chain, including a number of carbon atoms between 14 and 36.
摘要翻译： 用于在植入装置的植入部位输送至少一种活性成分的组合物，包括：至少一种活性成分，和至少一种与所述至少一种活性成分组合的第一赋形剂，其中至少选择第一赋形剂 在具有直链或支链饱和链的脂肪酸中，包括14至36之间的多个碳原子。
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公开(公告)号：US08084076B2
公开(公告)日：2011-12-27
申请号：US12027347
申请日：2008-02-07
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0068 , A61L31/084 , A61L2300/416 , A61L2300/606
摘要： A process for depositing an active substance on selected regions of the surface of a stent, comprising: (i) providing the active substance in at least one form selected from the group consisting of a powder and a paste; and (ii) depositing the active substance on the selected regions of the surface of the stent.Preferably, the active substance comprises or consists essentially of FK506, such as FK506 in the form of a powder with a grain size smaller than 15 micron or a paste with a base of FK506 with a viscosity not lower than 100,000 to 120,000 cps.
摘要翻译： 一种用于在支架表面的选定区域上沉积活性物质的方法，包括：（i）提供活性物质至少一种选自粉末和糊剂的形式; 和（ii）将活性物质沉积在支架表面的选定区域上。 优选地，活性物质包含或基本上由FK506，例如粒度小于15微米的粉末形式的FK506或具有粘度不低于100,000至120,000cps的FK506基料的糊剂组成或组成。
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公开(公告)号：US20080140186A1
公开(公告)日：2008-06-12
申请号：US12027347
申请日：2008-02-07
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0068 , A61L31/084 , A61L2300/416 , A61L2300/606
摘要： A process for depositing an active substance on selected regions of the surface of a stent, comprising: (i) providing the active substance in at least one form selected from the group consisting of a powder and a paste; and (ii) depositing the active substance on the selected regions of the surface of the stent.Preferably, the active substance comprises or consists essentially of FK506, such as FK506 in the form of a powder with a grain size smaller than 15 micron or a paste with a base of FK506 with a viscosity not lower than 100,000 to 120,000 cps.
摘要翻译： 一种用于在支架表面的选定区域上沉积活性物质的方法，包括：（i）提供活性物质至少一种选自粉末和糊剂的形式; 和（ii）将活性物质沉积在支架表面的选定区域上。 优选地，活性物质包含或基本上由FK506，例如粒度小于15微米的粉末形式的FK506或具有粘度不低于100,000至120,000cps的FK506基料的糊剂组成或组成。
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