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公开(公告)号：US20070092518A1
公开(公告)日：2007-04-26
申请号：US11496129
申请日：2006-07-31
申请人： Glen Evans , Katya McLane , Gopalan Raghunathan
发明人： Glen Evans , Katya McLane , Gopalan Raghunathan
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , C07K16/464 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Novel TNFα antibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to treat TNFα-related diseases are also disclosed.
摘要翻译： 公开了新的TNFα抗体多肽和核酸。 还公开了利用多肽治疗TNFα相关疾病的方法。
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公开(公告)号：US20090012266A1
公开(公告)日：2009-01-08
申请号：US12189237
申请日：2008-08-11
申请人： Glen A. Evans , Katya McLane , Gopalan Raghunathan
发明人： Glen A. Evans , Katya McLane , Gopalan Raghunathan
CPC分类号： C07K16/241 , C07K16/464 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Novel TNFα antibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to treat TNFα-related diseases are also disclosed.
摘要翻译： 公开了新的TNFα抗体多肽和核酸。 还公开了利用多肽治疗TNFα相关疾病的方法。
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公开(公告)号：US07790871B2
公开(公告)日：2010-09-07
申请号：US12189237
申请日：2008-08-11
申请人： Glen A. Evans , Katya McLane , Gopalan Raghunathan
发明人： Glen A. Evans , Katya McLane , Gopalan Raghunathan
IPC分类号： C12N15/00 , C07H21/04 , C07K16/00 , A61K39/395
CPC分类号： C07K16/241 , C07K16/464 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Novel TNFα antibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to treat TNFα-related diseases are also disclosed.
摘要翻译： 公开了新的TNFα抗体多肽和核酸。 还公开了利用多肽治疗TNFα相关疾病的方法。
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公开(公告)号：US07560108B2
公开(公告)日：2009-07-14
申请号：US11496129
申请日：2006-07-31
申请人： Glen A. Evans , Katya McLane , Gopalan Raghunathan
发明人： Glen A. Evans , Katya McLane , Gopalan Raghunathan
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/00 , C12N5/00
CPC分类号： C07K16/241 , C07K16/464 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Novel TNFα antibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to treat TNFα-related diseases are also disclosed.
摘要翻译： 公开了新的TNFα抗体多肽和核酸。 还公开了利用多肽治疗TNFα相关疾病的方法。
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5.发明授权CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds 有权衍生自将供体环合成接枝到CH2支架上的CH2结构域模板分子公开(公告)号：US09156917B2
公开(公告)日：2015-10-13
申请号：US13370831
申请日：2012-02-10
CPC分类号： C07K16/461 , C07K16/005 , C07K16/42 , C07K2317/524 , C07K2317/92 , C07K2317/94 , C40B30/04 , G01N33/6854
摘要： Novel CH2 domain template molecules wherein donor loops from a database of domains are transferred to a CH2 domain scaffold. At least one or up to three loops from a donor are transferred to the CH2 domain. The donor loops may be chosen based on length, e.g., the donor loop may have a length that is similar to that of a structural loop in the CH2 domain scaffold.
摘要翻译： 其中将来自结构域数据库的供体环转移到CH2结构域支架的新型CH2结构域模板分子。 来自供体的至少一个或多达三个环被转移到CH2结构域。 可以基于长度来选择供体环，例如，供体环可以具有与CH2结构域支架中的结构环的长度相似的长度。
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公开(公告)号：US20100074901A1
公开(公告)日：2010-03-25
申请号：US12251518
申请日：2008-10-15
申请人： Marc Hubert Mercken , Jacqueline M. Benson , Sun-Yung S. Jung , Haiyan Jiang , Gopalan Raghunathan , Lionella Borozdina-Birch
发明人： Marc Hubert Mercken , Jacqueline M. Benson , Sun-Yung S. Jung , Haiyan Jiang , Gopalan Raghunathan , Lionella Borozdina-Birch
IPC分类号： A61K39/395 , G01N33/567 , C12P21/06 , C12N5/00 , C12N5/02 , C12N1/00 , C07K16/18 , C07H21/04 , C12P21/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to at least one novel human anti-amyloid antibody, including isolated nucleic acids that encode at least one anti-amyloid antibody, amyloid, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的人抗淀粉样蛋白抗体，包括编码至少一种抗淀粉样蛋白抗体，淀粉样蛋白，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。
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7.发明申请公开(公告)号：US20060159695A1
公开(公告)日：2006-07-20
申请号：US11261356
申请日：2005-10-28
申请人： Alfred Delvecchio , Ping Tsui , Patrick Branigan , Leslee Conrad , Nicole Day , Changbao Liu , Raymond Sweet , Sheng-Jiun Wu , Jose Melero , Jinquan Luo , Gabriela Canziani , Mark Tornetta , Gopalan Raghunathan , Venkata Koka
发明人： Alfred Delvecchio , Ping Tsui , Patrick Branigan , Leslee Conrad , Nicole Day , Changbao Liu , Raymond Sweet , Sheng-Jiun Wu , Jose Melero , Jinquan Luo , Gabriela Canziani , Mark Tornetta , Gopalan Raghunathan , Venkata Koka
CPC分类号： C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K47/60 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2760/18522 , C12N2760/18534
摘要： Anti-Respiratory Syncytial Virus (RSV) monoclonal antibodies, RSV F protein antigens and their uses are disclosed.
摘要翻译： 公开了抗呼吸道合胞病毒（RSV）单克隆抗体，RSV F蛋白抗原及其用途。
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公开(公告)号：US20060115475A1
公开(公告)日：2006-06-01
申请号：US11291140
申请日：2005-11-30
申请人： Jill Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Mouhamadou Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Mouhamadou Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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9.发明申请TOLL LIKE RECEPTOR 3 ANTAGONISTS, METHODS AND USES 审中-公开TOLL LIKE RECEPTOR 3 ANTAGONISTS，METHODS AND USES公开(公告)号：US20140255388A1
公开(公告)日：2014-09-11
申请号：US13799476
申请日：2013-03-13
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Lamine Mbow , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Lamine Mbow , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/74 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US20130189250A1
公开(公告)日：2013-07-25
申请号：US13803887
申请日：2013-03-14
申请人： Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
发明人： Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
IPC分类号： C07K16/46
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
摘要翻译： 本发明涉及能够预防组织因子（凝血因子F3）信号传导但不干扰因子VII结合或FX与组织因子结合并且不延长凝血时间的抗体的人源化形式。 本发明的抗体可用于治疗相关细胞表达组织因子和组织因子信号传导的病症，例如肿瘤进展。
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