公开(公告)号：US08759759B2

公开(公告)日：2014-06-24

申请号：US13079740

申请日：2011-04-04

申请人： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

发明人： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC分类号： H01J49/00

CPC分类号： H01J49/423

摘要： The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

摘要翻译： 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US20120248307A1

公开(公告)日：2012-10-04

申请号：US13079740

申请日：2011-04-04

申请人： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

发明人： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC分类号： H01J49/34

CPC分类号： H01J49/423

摘要： The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

摘要翻译： 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US09105456B2

公开(公告)日：2015-08-11

申请号：US13576294

申请日：2011-01-26

申请人： Gongyu Jiang ,  Hui Mu ,  Li Ding

发明人： Gongyu Jiang ,  Hui Mu ,  Li Ding

IPC分类号： H01J49/06 ,  H01J49/00 ,  H01J49/42 ,  G01N30/72

CPC分类号： H01J49/063 ,  G01N30/7206 ,  H01J49/004 ,  H01J49/062 ,  H01J49/4215 ,  H01J49/4225

摘要： A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

摘要翻译： 在本发明中提供串联质谱仪。 质谱仪包括离子源，位于离子源下游侧的四极质量过滤器，设置在质量过滤器下游侧的线性离子阱和置于离子阱侧面的离子检测器 置于真空环境中。 仪器可以通过与线性离子阱配合的四极质谱仪获得满足标准光谱库检索标准的MS，实现轴向碰撞和共振激励两种模式下的任何多级MS，并预测和优化样品的流入量和类型 在离子阱分析模式下由四极杆。 还提供串联质谱分析方法，可重复提供前体离子选择，离子加速，实现高能碰撞解离，低离子质量鉴定效应。

公开(公告)号：US20120292498A1

公开(公告)日：2012-11-22

申请号：US13576294

申请日：2011-01-26

申请人： Gongyu Jiang ,  Hui Mu ,  Li Ding

发明人： Gongyu Jiang ,  Hui Mu ,  Li Ding

IPC分类号： H01J49/02 ,  H01J49/26

CPC分类号： H01J49/063 ,  G01N30/7206 ,  H01J49/004 ,  H01J49/062 ,  H01J49/4215 ,  H01J49/4225

摘要： A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

摘要翻译： 在本发明中提供串联质谱仪。 质谱仪包括离子源，位于离子源下游侧的四极质量过滤器，设置在质量过滤器下游侧的线性离子阱和置于离子阱侧面的离子检测器 置于真空环境中。 仪器可以通过与线性离子阱配合的四极质谱仪获得满足标准光谱库检索标准的MS，实现轴向碰撞和共振激励两种模式下的任何多级MS，并预测和优化样品的流入量和类型 在离子阱分析模式下由四极杆。 还提供串联质谱分析方法，可重复提供前体离子选择，离子加速，实现高能碰撞解离，低离子质量鉴定效应。

公开(公告)号：US08507848B1

公开(公告)日：2013-08-13

申请号：US13357470

申请日：2012-01-24

申请人： Li Ding ,  Gongyu Jiang ,  Wenjian Sun

发明人： Li Ding ,  Gongyu Jiang ,  Wenjian Sun

IPC分类号： H01J49/42 ,  H01J49/34 ,  H01J49/04

CPC分类号： H01J49/065 ,  H01J49/066

摘要： This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.

摘要翻译： 本发明提供了一种离子导向装置，其包括在空间上交叉的多层拉伸线电极。 这些线电极沿离子导向装置中限定的离子引导轴分布。 每层线电极包含至少两根与引导轴距离一定距离的线电极，并相对于相邻层上的线电极以一定角度旋转。 离子导向器包含多层线电极以形成笼状离子导向通道，并将这些线电极的安装框架保持在离子引导通道外部，从而减少离子导向装置的气流的干扰。 电源为每层线电极提供电压，产生将离子聚焦到引导轴的电场。