公开(公告)号：US08759759B2

公开(公告)日：2014-06-24

申请号：US13079740

申请日：2011-04-04

Applicant: Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

Inventor： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC: H01J49/00

CPC classification number: H01J49/423

Abstract: The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

Abstract translation: 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US20120248307A1

公开(公告)日：2012-10-04

申请号：US13079740

申请日：2011-04-04

Applicant: Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

Inventor： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC: H01J49/34

CPC classification number: H01J49/423

Abstract: The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

Abstract translation: 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US09105456B2

公开(公告)日：2015-08-11

申请号：US13576294

申请日：2011-01-26

Applicant: Gongyu Jiang ,  Hui Mu ,  Li Ding

Inventor： Gongyu Jiang ,  Hui Mu ,  Li Ding

IPC: H01J49/06 ,  H01J49/00 ,  H01J49/42 ,  G01N30/72

CPC classification number: H01J49/063 ,  G01N30/7206 ,  H01J49/004 ,  H01J49/062 ,  H01J49/4215 ,  H01J49/4225

Abstract: A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

Abstract translation: 在本发明中提供串联质谱仪。 质谱仪包括离子源，位于离子源下游侧的四极质量过滤器，设置在质量过滤器下游侧的线性离子阱和置于离子阱侧面的离子检测器 置于真空环境中。 仪器可以通过与线性离子阱配合的四极质谱仪获得满足标准光谱库检索标准的MS，实现轴向碰撞和共振激励两种模式下的任何多级MS，并预测和优化样品的流入量和类型 在离子阱分析模式下由四极杆。 还提供串联质谱分析方法，可重复提供前体离子选择，离子加速，实现高能碰撞解离，低离子质量鉴定效应。

公开(公告)号：US20120292498A1

公开(公告)日：2012-11-22

申请号：US13576294

申请日：2011-01-26

Applicant: Gongyu Jiang ,  Hui Mu ,  Li Ding

Inventor： Gongyu Jiang ,  Hui Mu ,  Li Ding

IPC: H01J49/02 ,  H01J49/26

CPC classification number: H01J49/063 ,  G01N30/7206 ,  H01J49/004 ,  H01J49/062 ,  H01J49/4215 ,  H01J49/4225

Abstract: A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

Abstract translation: 在本发明中提供串联质谱仪。 质谱仪包括离子源，位于离子源下游侧的四极质量过滤器，设置在质量过滤器下游侧的线性离子阱和置于离子阱侧面的离子检测器 置于真空环境中。 仪器可以通过与线性离子阱配合的四极质谱仪获得满足标准光谱库检索标准的MS，实现轴向碰撞和共振激励两种模式下的任何多级MS，并预测和优化样品的流入量和类型 在离子阱分析模式下由四极杆。 还提供串联质谱分析方法，可重复提供前体离子选择，离子加速，实现高能碰撞解离，低离子质量鉴定效应。

公开(公告)号：US08507848B1

公开(公告)日：2013-08-13

申请号：US13357470

申请日：2012-01-24

Applicant: Li Ding ,  Gongyu Jiang ,  Wenjian Sun

Inventor： Li Ding ,  Gongyu Jiang ,  Wenjian Sun

IPC: H01J49/42 ,  H01J49/34 ,  H01J49/04

CPC classification number: H01J49/065 ,  H01J49/066

Abstract: This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.

Abstract translation: 本发明提供了一种离子导向装置，其包括在空间上交叉的多层拉伸线电极。 这些线电极沿离子导向装置中限定的离子引导轴分布。 每层线电极包含至少两根与引导轴距离一定距离的线电极，并相对于相邻层上的线电极以一定角度旋转。 离子导向器包含多层线电极以形成笼状离子导向通道，并将这些线电极的安装框架保持在离子引导通道外部，从而减少离子导向装置的气流的干扰。 电源为每层线电极提供电压，产生将离子聚焦到引导轴的电场。

公开(公告)号：US20240341483A1

公开(公告)日：2024-10-17

申请号：US18300768

申请日：2023-04-14

Applicant: Li Ding

Inventor： Li Ding

IPC: A47C7/46

CPC classification number: A47C7/462

Abstract: A lumbar pillow that can move with the load bearing of the waist in 3D, comprising the lumbar pillow body, the middle part of the rear end of the lumbar pillow body is provided with a spring central axis mechanism; the spring central axis mechanism comprises the upper bottom plate, the spring and the lower bottom plate, the upper bottom plate is arranged in the middle of the rear end of the lumbar pillow body, the upper bottom plate is provided with a spring, and the other end of the spring is provided with a lower bottom plate; the middle part of the rear end of the lumbar pillow body is provided with a spring central axis mechanism, so that the upper bottom plate will be supported on the backrest of the seat, when the waist leans on the lumbar pillow, the spring will support the lumbar pillow.

公开(公告)号：US09633143B2

公开(公告)日：2017-04-25

申请号：US14110703

申请日：2012-04-05

Applicant: Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

Inventor： Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

IPC: G06G7/48 ,  G06F17/50

CPC classification number: G06F17/5009 ,  G06F17/5095

Abstract: A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.

公开(公告)号：US20130138093A1

公开(公告)日：2013-05-30

申请号：US13686952

申请日：2012-11-28

Applicant: Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

Inventor： Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

IPC: A61B18/20 ,  A61F2/14

CPC classification number: A61F2/14 ,  A61B18/20 ,  A61F2/142 ,  A61F2/1451 ,  A61F2/147 ,  A61F2/16 ,  A61F9/008 ,  A61L27/16 ,  A61L27/18 ,  A61L27/52 ,  B29D11/00355 ,  B29D11/00461 ,  B29D11/023 ,  B29K2083/00 ,  B29K2105/0061 ,  C08J7/12 ,  C08J7/123 ,  C08J2333/14 ,  C08J2339/06 ,  C08J2383/04 ,  G02B1/041 ,  G02C7/022 ,  G02C2202/12 ,  G02C2202/14

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Abstract translation: 一种光学装置，包括具有已经用激光照射的选择区域的光学水凝胶，所述激光具有0.01nJ至50nJ的脉冲能量和600nm至900nm的波长。 照射区域的特征在于折射率的正变化为0.01至0.06，并且表现出很小的或没有散射损失。 用亲水性单体制备光学水凝胶。

公开(公告)号：US20130026359A1

公开(公告)日：2013-01-31

申请号：US13634190

申请日：2011-04-22

Applicant: Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

Inventor： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

IPC: H01J49/26 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/10 ,  G01N27/622 ,  H01J49/066 ,  H01J49/161 ,  H01J49/164 ,  H01J49/165 ,  H01J49/24

Abstract: The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

Abstract translation: 本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。 气态中性分子通过解吸法在大气压下解吸。 然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。 然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

公开(公告)号：US08025892B2

公开(公告)日：2011-09-27

申请号：US10017259

申请日：2001-11-12

Applicant: Pascal E. Delrieu ,  Li Ding

Inventor： Pascal E. Delrieu ,  Li Ding

IPC: A61K31/14 ,  A61K8/02 ,  A61K9/14 ,  A61K9/50 ,  C11D1/62

CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: Gel particles or beads can be prepared by forming a hot aqueous solution of a gelling agent, and discharging the hot gelling agent solution through a discharge orifice into a cold moving stream of hydrophobic liquid so that the gelling agent solution cools rapidly and good quality gel particles coalesce in the cold hydrophobic liquid stream. The cold hydrophobic liquid stream can be contained in a conduit so that the cold hydrophobic liquid stream moves past the discharge orifice and exerts a force on hot solution in the discharge orifice, the force acting to withdraw the hot solution from the discharge orifice. Optionally, the gel particles can be crushable gel beads 10 formed of an agar complex providing cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Various active agents 16 may be bound to restraining polymer 14, for, example ascorbic acid, lactic acid or papain.

Abstract translation: 可以通过形成热胶凝剂的水溶液，并将热胶凝剂溶液通过排出孔排出到冷流动的疏水液体中，使得胶凝剂溶液快速冷却，并且优质的凝胶颗粒 在冷疏水性液体流中聚结。 冷疏水性液体流可以包含在导管中，使得冷的疏水性液体流移动通过排出孔，并且在排出孔中的热溶液上施加力，该力用于从排出孔抽出热溶液。 任选地，凝胶颗粒可以是由琼脂复合物形成的可压碎凝胶珠10，其提供用于局部递送生物或化妆活性剂的化妆品，药​​物等递送载体。 优选的琼脂珠10是具有抑制聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸 酸或木瓜蛋白酶。