公开(公告)号：USD771390S1

公开(公告)日：2016-11-15

申请号：US29522982

申请日：2015-04-06

申请人： Nathan Evan Rogers

设计人： Nathan Evan Rogers

CPC分类号： A46B15/00 ,  A46B17/04 ,  A46B17/065 ,  A46B2200/1066

公开(公告)号：US20130345193A1

公开(公告)日：2013-12-26

申请号：US13975238

申请日：2013-08-23

申请人： Jeffrey P. WHITTEN ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. WHITTEN ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D405/04 ,  C07D413/14 ,  C07D471/04 ,  C07D413/04 ,  C07D213/75 ,  C07D417/04

CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D493/10 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US08394848B2

公开(公告)日：2013-03-12

申请号：US13006701

申请日：2011-01-14

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/38

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US08383670B2

公开(公告)日：2013-02-26

申请号：US13050724

申请日：2011-03-17

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/38

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds of Formula (I): wherein A, J, Z, X, R1, and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述的是式（I）的化合物：其中A，J，Z，X，R 1和R 4在本文中定义，以及含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20120316182A1

公开(公告)日：2012-12-13

申请号：US13492574

申请日：2012-06-08

申请人： Jeffrey P. WHITTEN ,  Jonathan Grey ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

发明人： Jeffrey P. WHITTEN ,  Jonathan Grey ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

IPC分类号： A61K31/443 ,  C07D213/74 ,  A61K31/4418 ,  A61K31/497 ,  C07D417/04 ,  A61K31/4439 ,  A61K31/506 ,  A61P29/00 ,  A61P13/12 ,  A61P27/02 ,  A61P1/16 ,  A61P11/00 ,  A61P1/00 ,  A61P17/00 ,  A61P19/02 ,  A61P21/00 ,  A61P37/08 ,  A61P15/02 ,  A61P19/10 ,  A61P37/06 ,  A61P19/04 ,  A61P3/10 ,  A61P5/16 ,  A61P21/04 ,  A61P7/06 ,  A61P31/14 ,  A61P11/06 ,  A61P17/06 ,  A61P25/00 ,  A61P37/00 ,  C07D405/10

CPC分类号： C07D405/04 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  C07D213/74 ,  C07D239/47 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/10 ,  C07D417/04 ,  C07D491/04 ,  C07D491/056

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20120053210A1

公开(公告)日：2012-03-01

申请号：US13219393

申请日：2011-08-26

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/4439 ,  A61K31/423 ,  C07D417/10 ,  A61K31/428 ,  C07D409/10 ,  A61K31/416 ,  C07D413/14 ,  A61K31/4245 ,  A61K31/427 ,  C07D417/14 ,  A61P29/00 ,  A61P27/02 ,  A61P1/16 ,  A61P13/12 ,  A61P11/00 ,  A61P1/00 ,  A61P7/00 ,  A61P17/00 ,  A61P19/02 ,  A61P37/08 ,  A61P15/02 ,  A61P19/10 ,  A61P37/06 ,  A61P19/04 ,  A61P3/10 ,  A61P5/14 ,  A61P21/04 ,  A61P7/06 ,  A61P31/12 ,  A61P27/14 ,  A61P11/06 ,  A61P17/06 ,  A61P25/00 ,  A61P37/00 ,  C12N5/071 ,  C07D413/10

CPC分类号： C07D413/04 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0048 ,  A61K9/007 ,  A61K9/02 ,  A61K9/4866 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US07981925B2

公开(公告)日：2011-07-19

申请号：US12548186

申请日：2009-08-26

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/38

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US08754219B2

公开(公告)日：2014-06-17

申请号：US13643537

申请日：2011-04-27

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/44 ,  C07D221/02

CPC分类号： C07D417/12 ,  C07C233/75 ,  C07C233/80 ,  C07C233/92 ,  C07C255/60 ,  C07C2601/02 ,  C07D213/81 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US08618307B2

公开(公告)日：2013-12-31

申请号：US12883014

申请日：2010-09-15

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

IPC分类号： C07D263/58

CPC分类号： C07D409/12 ,  C07D333/38 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US08372991B2

公开(公告)日：2013-02-12

申请号：US13050356

申请日：2011-03-17

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D409/00

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds of Formula (I): wherein A, J, Z, X, R1 and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述的是式（I）的化合物：其中A，J，Z，X，R 1和R 4在本文中定义，以及含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。