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    Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal
    1.
    发明授权
    Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal 有权
    识别在PD-1介导的信号存在下上调T细胞活化的化合物的方法

    公开(公告)号：US07432059B2

    公开(公告)日：2008-10-07

    申请号：US09895837

    申请日：2001-06-28

    申请人： Gordon Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive Wood ,  Yvette Latchman ,  Arlene H. Sharpe

    发明人： Gordon Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive Wood ,  Yvette Latchman ,  Arlene H. Sharpe

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6854 ,  G01N33/5014 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/573 ,  G01N2800/52

    摘要： The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. The invention further provides methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1-mediated signal. Diagnostic and treatment methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为PD-L2核酸分子，其编码作为PD-1配体的新型B7相关分子。 本发明还提供了反义核酸分子，含有PD-L2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已导入或破坏了PD-L2基因的非人类转基因动物。 本发明进一步提供分离的PD-L2多肽，融合蛋白，抗原肽和抗-PD-L2抗体。 本发明还提供了促进或抑制PD-L2与PD-1之间相互作用的方法。 本发明还提供鉴定在PD-1介导的信号存在下上调T细胞活化的化合物的方法。 还提供了利用本发明组合物的诊断和治疗方法。

    PD-L2 Molecules: Novel PD-1 Ligands and Uses Therefor
    2.
    发明申请
    PD-L2 Molecules: Novel PD-1 Ligands and Uses Therefor 有权
    PD-L2分子：新型PD-1配体及其用途

    公开(公告)号：US20080118511A1

    公开(公告)日：2008-05-22

    申请号：US11765838

    申请日：2007-06-20

    申请人： Gordon Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive R. Wood

    发明人： Gordon Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive R. Wood

    IPC分类号： A61K39/395 ,  C12N5/00 ,  A61K38/16 ,  A61P35/00 ,  A61P37/06 ,  A61P31/00

    CPC分类号： G01N33/6854 ,  G01N33/5014 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/573 ,  G01N2800/52

    摘要： The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. Diagnostic and treatment methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为PD-L2核酸分子，其编码作为PD-1配体的新型B7相关分子。 本发明还提供了反义核酸分子，含有PD-L2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已导入或破坏了PD-L2基因的非人类转基因动物。 本发明进一步提供分离的PD-L2多肽，融合蛋白，抗原肽和抗-PD-L2抗体。 本发明还提供了促进或抑制PD-L2与PD-1之间相互作用的方法。 还提供了利用本发明组合物的诊断和治疗方法。

    Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1
    3.
    发明授权
    Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1 有权
    用抑制PD-L2和PD-1之间的相互作用的试剂上调免疫应答的方法

    公开(公告)号：US07709214B2

    公开(公告)日：2010-05-04

    申请号：US11765838

    申请日：2007-06-20

    申请人： Gordon J. Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive R. Wood

    发明人： Gordon J. Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive R. Wood

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6854 ,  G01N33/5014 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/573 ,  G01N2800/52

    摘要： The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. Diagnostic and treatment methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为PD-L2核酸分子，其编码作为PD-1配体的新型B7相关分子。 本发明还提供了反义核酸分子，含有PD-L2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已导入或破坏了PD-L2基因的非人类转基因动物。 本发明进一步提供分离的PD-L2多肽，融合蛋白，抗原肽和抗-PD-L2抗体。 本发明还提供了促进或抑制PD-L2与PD-1之间相互作用的方法。 还提供了利用本发明组合物的诊断和治疗方法。