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    Chinese herbs extract
    2.
    发明授权
    Chinese herbs extract 失效
    中药提取物

    公开(公告)号：US06399112B1

    公开(公告)日：2002-06-04

    申请号：US08750848

    申请日：1996-12-24

    申请人： Brian Anthony Whittle ,  Jonathan Brostoff ,  Yvette Latchman

    发明人： Brian Anthony Whittle ,  Jonathan Brostoff ,  Yvette Latchman

    IPC分类号： A61K3578

    CPC分类号： A61K36/804 ,  A61K36/00 ,  A61K36/185 ,  A61K36/238 ,  A61K36/48 ,  A61K36/484 ,  A61K36/538 ,  A61K36/65 ,  A61K36/716 ,  A61K36/73 ,  A61K36/75 ,  A61K36/899 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/887 ,  A61K2300/00

    摘要： This application relates to a material which is suitable for the treatment of atopic disease, non-atopic eczema or psoriasis. The material can be extracted from a freeze-dried decoction of a mixture comprising the following Chinese herbs: Radix Ledebouriella, Fructus Tribuli, Herba Potentilla chinensis, Caulis Clematis armandii, Radix Rehmannia, Radix Glycyrrhiza, Radix Paeonia rubra, Cortex Dictamni radicis, Herba Lopatheri, Spica Schizonepetae. The material comprises one or more of those components present in the freeze-dried decoction which run with Rf values in the ranges 0.00 to 0.100, 0.167 to 0.300, 0.400 to 0.533, 0.700 to 0.833 or 0.900 to 0.967 if the freeze-dried decoction is diluted in aqueous solution and subjected to chromatography on a Whatman 2 cms×55 cms×3 mm cellulose strip for 10 hours using a solvent mixture of butanol, ethanol and water in the proportions 4:1:1.

    摘要翻译： 本申请涉及适用于治疗特应性疾病，非特应性湿疹或牛皮癣的材料。 该材料可以从包含以下中草药的混合物的冷冻干燥汤中提取：枸杞，枸杞，中华Her草，铁线莲，地黄，甘草，芍药，茯苓，草本茯苓 ，Spica Schizonepetae。 该物质包含存在于冷冻干燥煎煮中的一种或多种组分，如果冷冻干燥的煎煮是在冰冷干燥汤中，则以Rf值为范围为0.00至0.100,0.167至0.300,0.400至0.533,0.700至0.833或0.900至0.967 在水溶液中稀释，并在Whatman 2 cmsx55 cmsx3 mm纤维素条上进行色谱分离，使用丁醇，乙醇和水的溶剂混合物，比例为4:1:1。

    Chinese herbs extract
    3.
    发明授权
    Chinese herbs extract 失效
    中药提取物

    公开(公告)号：US07341746B2

    公开(公告)日：2008-03-11

    申请号：US10716506

    申请日：2003-11-20

    申请人： Brian Anthony Whittle ,  Jonathan Brostoff ,  Yvette Latchman

    发明人： Brian Anthony Whittle ,  Jonathan Brostoff ,  Yvette Latchman

    IPC分类号： A61K36/00

    CPC分类号： A61K36/804 ,  A61K36/00 ,  A61K36/185 ,  A61K36/238 ,  A61K36/48 ,  A61K36/484 ,  A61K36/538 ,  A61K36/65 ,  A61K36/716 ,  A61K36/73 ,  A61K36/75 ,  A61K36/899 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/887 ,  A61K2300/00

    摘要： This application relates to a material which is suitable for the treatment of atopic disease, non-atopic eczema or psoriasis. The material can be extracted from a freeze-dried decoction of a mixture comprising the following Chinese herbs: Radix Ledebouriella, Fructus Tribuli, Herba Potentilla chinensis, Caulis Clematis armandii, Radix Rehmannia, Radix Glycyrrhiza, Radix Paeonia rubra, Cortex Dictamni radicis, Herba Lopatheri, Spica Schizonepetae. The material comprises one or more of those components present in the freeze-dried decoction which run with Rf values in the ranges 0.00 to 0.100, 0.167 to 0.300, 0.400 to 0.533, 0.700 to 0.833 or 0.900 to 0.967 if the freeze-dried decoction is diluted in aqueous solution and subjected to chromatography on a Whatman 2 cms×55 cms×3 mm cellulose strip for 10 hours using a solvent mixture of butanol, ethanol and water in the proportions 4:1:1.

    摘要翻译： 本申请涉及适用于治疗特应性疾病，非特应性湿疹或牛皮癣的材料。 该材料可以从包含以下中草药的混合物的冷冻干燥汤中提取：枸杞，枸杞，中华Her草，铁线莲，地黄，甘草，芍药，茯苓，草本茯苓 ，Spica Schizonepetae。 该物质包含存在于冷冻干燥煎煮中的一种或多种组分，如果冷冻干燥的煎煮是在冰冷干燥汤中，则以Rf值为范围为0.00至0.100,0.167至0.300,0.400至0.533,0.700至0.833或0.900至0.967 在水溶液中稀释，并在Whatman 2 cmsx55 cmsx3 mm纤维素条上进行色谱分离，使用丁醇，乙醇和水的溶剂混合物，比例为4:1:1。

    Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal
    4.
    发明授权
    Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal 有权
    识别在PD-1介导的信号存在下上调T细胞活化的化合物的方法

    公开(公告)号：US07432059B2

    公开(公告)日：2008-10-07

    申请号：US09895837

    申请日：2001-06-28

    申请人： Gordon Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive Wood ,  Yvette Latchman ,  Arlene H. Sharpe

    发明人： Gordon Freeman ,  Irene Chernova ,  Tatyana Chernova ,  Nelly Malenkovich ,  Clive Wood ,  Yvette Latchman ,  Arlene H. Sharpe

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6854 ,  G01N33/5014 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/573 ,  G01N2800/52

    摘要： The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. The invention further provides methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1-mediated signal. Diagnostic and treatment methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为PD-L2核酸分子，其编码作为PD-1配体的新型B7相关分子。 本发明还提供了反义核酸分子，含有PD-L2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已导入或破坏了PD-L2基因的非人类转基因动物。 本发明进一步提供分离的PD-L2多肽，融合蛋白，抗原肽和抗-PD-L2抗体。 本发明还提供了促进或抑制PD-L2与PD-1之间相互作用的方法。 本发明还提供鉴定在PD-1介导的信号存在下上调T细胞活化的化合物的方法。 还提供了利用本发明组合物的诊断和治疗方法。

    Chinese herbal composition for treating eczema and psoriasis
    5.
    发明授权
    Chinese herbal composition for treating eczema and psoriasis 失效
    用于治疗湿疹和牛皮癣的中草药组合物

    公开(公告)号：US06676975B2

    公开(公告)日：2004-01-13

    申请号：US10074039

    申请日：2002-02-14

    申请人： Brian Anthony Whittle ,  Jonathan Brostoff ,  Yvette Latchman

    发明人： Brian Anthony Whittle ,  Jonathan Brostoff ,  Yvette Latchman

    IPC分类号： A61K3578

    CPC分类号： A61K36/804 ,  A61K36/00 ,  A61K36/185 ,  A61K36/238 ,  A61K36/48 ,  A61K36/484 ,  A61K36/538 ,  A61K36/65 ,  A61K36/716 ,  A61K36/73 ,  A61K36/75 ,  A61K36/899 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/887 ,  A61K2300/00

    摘要： This application relates to a material which is suitable for the treatment of atopic disease, non-atopic eczema or psoriasis. The material can be extracted from a freeze-dried decoction of a mixture comprising the following Chinese herbs: Radix Ledebouriella, Fructus Tribuli, Herba Potentilla chinensis, Caulis Clematis armandii, Radix Rehmannia, Radix Glycyrrhiza, Radix Paeonia rubra, Cortex Dictamni radicis, Herba Lopatheri, Spica Schizonepetae. The material comprises one or more of those components present in the freeze-dried decoction which run with Rf values in the ranges 0.00 to 0.100, 0.167 to 0.300, 0.400 to 0.533, 0.700 to 0.833 or 0.900 to 0.967 if the freeze-dried decoction is diluted in aqueous solution and subjected to chromatography on a Whatman 2 cms×55 cms×3 mm cellulose strip for 10 hours using a solvent mixture of butanol, ethanol and water in the proportions 4:1:1.

    摘要翻译： 本申请涉及适用于治疗特应性疾病，非特应性湿疹或牛皮癣的材料。 该材料可以从包含以下中草药的混合物的冷冻干燥汤中提取：枸杞，枸杞，中华Her草，铁线莲，地黄，甘草，芍药，茯苓，草本茯苓 ，Spica Schizonepetae。 该物质包含存在于冷冻干燥煎煮中的一种或多种组分，如果冷冻干燥的煎煮是在冰冷干燥汤中，则以Rf值为范围为0.00至0.100,0.167至0.300,0.400至0.533,0.700至0.833或0.900至0.967 在水溶液中稀释，并在Whatman 2 cmsx55 cmsx3 mm纤维素条上进行色谱分离，使用丁醇，乙醇和水的溶剂混合物，比例为4:1:1。