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    Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof
    1.
    发明授权
    Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof 有权
    调节B7-1多肽与PD-L1的相互作用的试剂及其使用方法

    公开(公告)号：US07722868B2

    公开(公告)日：2010-05-25

    申请号：US11501392

    申请日：2006-08-09

    申请人： Gordon J. Freeman ,  Arlene H. Sharpe ,  Janet Buhlman ,  Didier Mandelbrot

    发明人： Gordon J. Freeman ,  Arlene H. Sharpe ,  Janet Buhlman ,  Didier Mandelbrot

    IPC分类号： A61K39/395

    CPC分类号： G01N33/6854 ,  A61K38/1709 ,  G01N33/505 ,  G01N33/6872 ,  G01N2333/70532 ,  G01N2500/02

    摘要： Disclosed are methods for modulating an immune response including a method for inhibiting the interaction between a B7 polypeptide and a PD-1 ligand, the method comprising contacting an immune cell bearing a PD-1 ligand, or an immune cell bearing a B7 polypeptide, with an agent that inhibits the interaction between the PD-1 ligand and the B7 polypeptide. Such agents may be an anti-PD-1 ligand antibody or a small molecule. Also disclosed is a method for modulating an immune response comprising contacting an immune cell bearing the PD-1 ligand, or an immune cell bearing the PD-1 polypeptide, with an agent that inhibits interactions between the PD-1 ligand and the PD-1 polypeptide, without inhibiting interactions between the PD-1 ligand and a B7 polypeptide, to thereby modulate an immune response. The agent may be an anti-PD-1 ligand antibody or a small molecule.

    摘要翻译： 公开了用于调节免疫应答的方法，包括抑制B7多肽和PD-1配体之间的相互作用的方法，所述方法包括使带有PD-1配体或带有B7多肽的免疫细胞的免疫细胞与 抑制PD-1配体和B7多肽之间的相互作用的试剂。 这样的试剂可以是抗PD-1配体抗体或小分子。 还公开了一种用于调节免疫应答的方法，包括将携带PD-1配体或携带PD-1多肽的免疫细胞的免疫细胞与抑制PD-1配体和PD-1之间的相互作用的试剂接触 多肽，而不抑制PD-1配体和B7多肽之间的相互作用，从而调节免疫应答。 该试剂可以是抗PD-1配体抗体或小分子。

    B7-specific antibodies
    2.
    发明授权
    B7-specific antibodies 失效
    B7特异性抗体

    公开(公告)号：US06608180B2

    公开(公告)日：2003-08-19

    申请号：US09837867

    申请日：2001-04-17

    申请人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    发明人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    IPC分类号： C07K1628

    CPC分类号： C07K14/70532 ,  A01K2217/05

    摘要： Novel structural forms of T cell costimulatory molecules are described. These structural forms comprise a novel structural domain or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. In one embodiment, the T cell costimulatory molecule of the invention contains a novel cytoplasmic domain. In another embodiment, the T cell costimulatory molecule of the invention contains a novel signal peptide domain or has an immunoglobulin variable region-like domain deleted. The novel structural forms of T cell costimulatory molecules can be used to identify agents which stimulate the expression of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.

    摘要翻译： 描述了T细胞共刺激分子的新型结构形式。 这些结构形式包括一个新的结构域或者具有缺失或添加的结构域。 结构形式对应于可以通过标准重组DNA技术产生的天然存在的可变剪接形式的T细胞共刺激分子或其变体。 在一个实施方案中，本发明的T细胞共刺激分子含有新的细胞质结构域。 在另一个实施方案中，本发明的T细胞共刺激分子含有新的信号肽结构域或具有免疫球蛋白可变区域结构域缺失。 T细胞共刺激分子的新型结构形式可用于鉴定刺激替代形式的共刺激分子表达的试剂，并鉴定导致T细胞共刺激的信号转导通路的成分。

    B7-1 and B7-2 polypeptides
    3.
    发明授权
    B7-1 and B7-2 polypeptides 失效
    B7-1和B7-2多肽

    公开(公告)号：US06218510B1

    公开(公告)日：2001-04-17

    申请号：US08205697

    申请日：1994-03-02

    申请人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    发明人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    IPC分类号： C07K1447

    CPC分类号： C07K14/70532 ,  A01K2217/05

    摘要： Structural forms of T cell costimulatory B7-1 and B7-2 molecules are described. These structural forms comprise a structural domain or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. In one embodiment, the T cell costimulatory molecule of the invention contains a cytoplasmic domain. In another embodiment, the T cell costimulatory molecule of the invention contains a signal peptide domain or has an immunoglobulin variable region-like domain deleted. The structural forms of T cell costimulatory molecules can be used to identify agents which stimulate the expression of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.

    摘要翻译： 描述了T细胞共刺激B7-1和B7-2分子的结构形式。 这些结构形式包括结构域或缺失或添加结构域。 结构形式对应于可以通过标准重组DNA技术产生的天然存在的可变剪接形式的T细胞共刺激分子或其变体。 在一个实施方案中，本发明的T细胞共刺激分子含有细胞质结构域。 在另一个实施方案中，本发明的T细胞共刺激分子含有信号肽结构域或具有免疫球蛋白可变区域结构域缺失。 T细胞共刺激分子的结构形式可用于鉴定刺激替代形式的共刺激分子表达的试剂，并鉴定导致T细胞共刺激的信号转导通路的成分。

    Nucleic acid molecules encoding B7-1
    4.
    发明授权
    Nucleic acid molecules encoding B7-1 失效
    编码B7-1的核酸分子

    公开(公告)号：US07619078B2

    公开(公告)日：2009-11-17

    申请号：US11589275

    申请日：2006-10-26

    申请人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    发明人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    IPC分类号： C12N15/12 ,  C12N15/11 ,  C07K14/705

    CPC分类号： C07K14/70532 ,  A01K2217/05

    摘要： Novel structural forms of T cell costimulatory molecules are described. These structural forms comprise a novel structural domain or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. In one embodiment, the T cell costimulatory molecule of the invention contains a novel cytoplasmic domain. In another embodiment, the T cell costimulatory molecule of the invention contains a novel signal peptide domain or has an immunoglobulin variable region-like domain deleted. The novel structural forms of T cell costimulatory molecules can be used to identify agents which stimulate the expression of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.

    摘要翻译： 描述了T细胞共刺激分子的新型结构形式。 这些结构形式包括一个新的结构域或者具有缺失或添加的结构域。 结构形式对应于可以通过标准重组DNA技术产生的天然存在的可变剪接形式的T细胞共刺激分子或其变体。 在一个实施方案中，本发明的T细胞共刺激分子含有新的细胞质结构域。 在另一个实施方案中，本发明的T细胞共刺激分子含有新的信号肽结构域或具有免疫球蛋白可变区域结构域缺失。 T细胞共刺激分子的新型结构形式可用于鉴定刺激替代形式的共刺激分子表达的试剂，并鉴定导致T细胞共刺激的信号转导通路的成分。

    T cell costimulatory polypeptides containing alternative domains
    5.
    发明授权
    T cell costimulatory polypeptides containing alternative domains 失效
    含有替代结构域的T细胞共刺激多肽

    公开(公告)号：US07153934B2

    公开(公告)日：2006-12-26

    申请号：US09962969

    申请日：2001-09-24

    申请人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    发明人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    IPC分类号： C07K14/435 ,  C07K14/705

    CPC分类号： C07K14/70532 ,  A01K2217/05

    摘要： Structural forms of T cell costimulatory polypeptides are described. These forms comprise an alternative structural domain (i.e., a structural domain having an amino acid sequence which differs from a known amino acid sequence) or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory polypeptides or variants thereof which can be produced by standard recombinant DNA techniques. In one embodiment, the T cell costimulatory polypeptide of the invention contains an alternative cytoplasmic domain. In another embodiment, the T cell costimulatory polypeptide of the invention contains an alternative signal peptide domain or has an immunoglobulin variable region-like domain deleted. The alternative structural forms of T cell costimulatory polypeptides can be used to identify agents which stimulate the expression of alternative forms of costimulatory polypeptides and to identify components of the signal transduction pathway which results in costimulation of T cells.

    摘要翻译： 描述了T细胞共刺激多肽的结构形式。 这些形式包括可选择的结构域（即，具有不同于已知氨基酸序列的氨基酸序列的结构域）或具有缺失或添加的结构域。 结构形式对应于可以通过标准重组DNA技术产生的天然存在的可变剪接形式的T细胞共刺激多肽或其变体。 在一个实施方案中，本发明的T细胞共刺激多肽含有替代细胞质结构域。 在另一个实施方案中，本发明的T细胞共刺激多肽含有替代的信号肽结构域或具有免疫球蛋白可变区域结构域缺失。 T细胞共刺激多肽的替代结构形式可用于鉴定刺激替代形式的共刺激多肽的表达并鉴定导致T细胞共刺激的信号转导途径的组分的试剂。

    Nucleic acids encoding B7-1 and B7-2 molecules
    6.
    发明授权
    Nucleic acids encoding B7-1 and B7-2 molecules 失效
    编码B7-1和B7-2分子的核酸

    公开(公告)号：US06294660B1

    公开(公告)日：2001-09-25

    申请号：US08702525

    申请日：1997-02-07

    申请人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    发明人： Arlene H. Sharpe ,  Francescopaolo Borriello ,  Gordon J. Freeman ,  Lee M. Nadler

    IPC分类号： C12N1512

    CPC分类号： C07K14/70532 ,  A01K2217/05

    摘要： Nucleic acids encoding B7-1 and B7-2 molecules which bind CD28 or CTLA4 are described. These structural forms correspond to naturally-occurring alternatively spliced forms comprising cytoplasmic and signal peptide domains of T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. These T cell costimulatory molecules can be used to identify agents which stimulate the express of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.

    摘要翻译： 描述编码结合CD28或CTLA4的B7-1和B7-2分子的核酸。 这些结构形式对应于可以通过标准重组DNA技术产生的包含T细胞共刺激分子或其变体的细胞质和信号肽结构域的天然存在的可变剪接形式。 这些T细胞共刺激分子可以用于鉴定刺激替代形式的共刺激分子的表达的试剂，并鉴定导致T细胞共刺激的信号转导通路的成分。