-
公开(公告)号：US07078438B2
公开(公告)日：2006-07-18
申请号：US11051142
申请日：2005-02-04
申请人： Gordon William Rewcastle , Julie Ann Spicer , Stephen Douglas Barrett , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle
发明人： Gordon William Rewcastle , Julie Ann Spicer , Stephen Douglas Barrett , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle
IPC分类号： A61K31/165
CPC分类号： C07C317/36 , C07C259/10 , C07C323/36 , Y10S514/825
摘要： The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及4-取代苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。
-
公开(公告)号：US06891066B2
公开(公告)日：2005-05-10
申请号：US10349801
申请日：2003-01-23
申请人： Gordon William Rewcastle , Julie Ann Spicer , Stephen Douglas Barrett , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle
发明人： Gordon William Rewcastle , Julie Ann Spicer , Stephen Douglas Barrett , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle
IPC分类号： A61P9/04 , A61K31/165 , A61K31/166 , A61K31/18 , A61K31/21 , A61K31/27 , A61K31/66 , A61P9/10 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C229/58 , C07C233/65 , C07C237/28 , C07C259/10 , C07C311/45 , C07C317/36 , C07C323/36 , C07C323/39
CPC分类号： C07C317/36 , C07C259/10 , C07C323/36 , Y10S514/825
摘要： The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及4-取代苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。
-
公开(公告)号：US07160915B2
公开(公告)日：2007-01-09
申请号：US10897464
申请日：2004-07-22
申请人： Stephen Douglas Barrett , Cathlin Marie Flamme , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle , Joseph Scott Warmus
发明人： Stephen Douglas Barrett , Cathlin Marie Flamme , Michael David Kaufman , Jared Bruce John Milbank , Haile Tecle , Joseph Scott Warmus
IPC分类号： A61K31/4184 , C07D235/22 , C07D235/06
CPC分类号： C07D235/06 , C07D235/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/04
摘要： The present invention relates to N-methyl-substituted benzamidazole derivatives of formula (I): as defined in the specification; pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及式（I）的N-甲基取代的苯甲胺唑衍生物：如说明书中所定义; 药物组合物及其使用方法。
-
公开(公告)号：US07411001B2
公开(公告)日：2008-08-12
申请号：US11102307
申请日：2005-04-07
申请人： Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael Huai Gu Chen , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
发明人： Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael Huai Gu Chen , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
IPC分类号： A61K31/215 , C07C239/00
CPC分类号： C07D261/02 , C07C259/10 , C07C271/16 , C07C2601/02 , C07D295/088 , C07D317/18 , C07D319/06
摘要： The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystalline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。 本发明还涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯的结晶形式，药物组合物及其使用方法。
-
公开(公告)号：US06960614B2
公开(公告)日：2005-11-01
申请号：US10333399
申请日：2001-07-12
申请人： Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
发明人： Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
IPC分类号： C07D261/12 , A61K31/337 , A61K31/42 , A61K31/475 , A61K45/00 , A61K51/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/04 , A61P29/00 , A61P31/12 , A61P35/00 , C07C259/00 , C07C259/10 , C07D261/02 , C07D295/088 , C07D317/18 , C07D319/06 , A61K31/215 , C07C239/00
CPC分类号： C07D261/02 , C07C259/10 , C07C271/16 , C07C2601/02 , C07D295/088 , C07D317/18 , C07D319/06
摘要： The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystaline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。 本发明还涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯的结晶形式，药物组合物及其使用方法。
-
公开(公告)号：US06440966B1
公开(公告)日：2002-08-27
申请号：US09869639
申请日：2001-07-02
IPC分类号： C07D295027
CPC分类号： C07C311/39 , C07C2601/02
摘要： Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
摘要翻译： 其中W是OR1，NR2OR1，NRARB，NR2NRARB或NR2（CH2）2-4NRARB的式（I）的苯磺酰胺和权利要求中定义的其它变量是MEK的抑制剂，并且在治疗增殖性疾病中是有效的 ，癌症，中风，心力衰竭，异种移植排斥，关节炎，囊性纤维化，肝肿大，心脏肥大，阿尔茨海默病，糖尿病并发症，败血性休克和病毒感染。
-
7.发明授权Method of treating or preventing septic shock by administering a MEK inhibitor 失效通过施用MEK抑制剂治疗或预防败血性休克的方法公开(公告)号：US06251943B1
公开(公告)日：2001-06-26
申请号：US09355680
申请日：1999-08-02
申请人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
IPC分类号： A61K31195
CPC分类号： A61K31/135 , A61K31/165 , A61K31/18 , A61K31/195 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , Y10S514/921
摘要： The present invention provides a method for treating or preventing septic shock. Specifically, the present invention provides a method of treating or preventing septic shock by administering to a patient a MEK inhibitor.
摘要翻译： 本发明提供治疗或预防败血性休克的方法。 具体地，本发明提供了通过向患者施用MEK抑制剂来治疗或预防败血性休克的方法。
-
公开(公告)号：US07030119B1
公开(公告)日：2006-04-18
申请号：US10031037
申请日：2000-07-05
申请人： Stephen Douglas Barrett , Alexander James Bridges , Haile Tecle , Alistair Dixon , Kevin Lee , Robert Pinnock
发明人： Stephen Douglas Barrett , Alexander James Bridges , Haile Tecle , Alistair Dixon , Kevin Lee , Robert Pinnock
IPC分类号： A61K31/495 , A61K31/41 , A61K31/425
CPC分类号： A61K31/41 , A61K31/425 , A61K31/495
摘要： The invention features a method for treating chronic pain using a compound of formula (I).
摘要翻译： 本发明的特征在于使用式（I）化合物治疗慢性疼痛的方法。
-
公开(公告)号：US07019033B2
公开(公告)日：2006-03-28
申请号：US10315654
申请日：2002-12-10
申请人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/277 , A61K31/198
CPC分类号： C07D213/40 , C07C215/68 , C07C229/58 , C07C237/08 , C07C237/16 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/36 , C07C237/38 , C07C239/22 , C07C243/38 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D257/04 , C07D257/06 , C07D295/13 , C07D295/155 , C07D295/32 , C07D333/20
摘要： Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
摘要翻译： 苯基氨基苯甲酸，苯甲酰胺和下式的苄醇衍生物其中R 1，R 2，R 3，R 4， R 5，R 5和R 6是氢或取代基如烷基，其中R 7是氢或有机基团 ，Z为COOR 7，四唑基，CONR 6 R 7或CH 2 2或7 是MEK的有效抑制剂，因此在治疗癌症和其它增殖性疾病如炎症，牛皮癣和再狭窄以及中风，心力衰竭和免疫缺陷障碍中都是有效的。
-
10.发明授权4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors 失效4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US06821963B2
公开(公告)日：2004-11-23
申请号：US10163890
申请日：2002-06-04
申请人： Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
IPC分类号： A61K31397
CPC分类号： C07D295/088 , C07C259/10 , C07D211/22 , C07D213/30 , C07D307/42 , C07D309/06 , C07D333/16
摘要： Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5和R 6是氢或取代基如烷基，且其中R 7是氢或有机基团的式（I）的苯基氨基苯并肟酸衍生物是MEK的有效抑制剂 ，有效治疗癌症和其他增殖性疾病如牛皮癣和再狭窄。
-
-
-
-
-
-
-
-
-
搜索结果
52 条记录 (耗时 0.043 秒)
