公开(公告)号：US20060264427A1

公开(公告)日：2006-11-23

申请号：US11403606

申请日：2006-04-13

申请人： Graeme Smith ,  Niall Martin ,  Keith Menear ,  Marc Hummersone ,  Xiao-ling Cockcroft ,  Mark Frigerio ,  Roger Griffin ,  Bernard Golding ,  Ian Hardcastle ,  David Newell ,  HiIary Calvert ,  Nicola Curtin ,  Kappusamy Saravanan ,  Marine Desage-El Murr

发明人： Graeme Smith ,  Niall Martin ,  Keith Menear ,  Marc Hummersone ,  Xiao-ling Cockcroft ,  Mark Frigerio ,  Roger Griffin ,  Bernard Golding ,  Ian Hardcastle ,  David Newell ,  HiIary Calvert ,  Nicola Curtin ,  Kappusamy Saravanan ,  Marine Desage-El Murr

IPC分类号： A61K31/541 ,  A61K31/5377 ,  C07D487/02

CPC分类号： C07D413/00 ,  C07D401/14 ,  C07D405/04 ,  C07D407/04 ,  C07D407/14 ,  C07D409/04 ,  C07D471/04

摘要： Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(═O), CH2 and NH are disclosed for use in inhibiting DNA-PK.

摘要翻译： 式I化合物：其中A，B和D分别选自：（i）CH，NH，C; （ii）CH，N，N;和（iii）CH，O，C; 虚线表示适当位置的两个双键; 并且其中Z选自S，O，C（-O），CH 2和NH，用于抑制DNA-PK。

公开(公告)号：US20060264623A1

公开(公告)日：2006-11-23

申请号：US11403763

申请日：2006-04-13

申请人： Graeme Smith ,  Niall Martin ,  Keith Menear ,  Marc Hummersone ,  Xiao-ling Cockcroft ,  Mark Frigerio ,  Roger Griffin ,  Bernard Golding ,  Ian Hardcastle ,  David Newell ,  Hilary Calvert ,  Nicola Curtin ,  Marine Desage-El Murr

发明人： Graeme Smith ,  Niall Martin ,  Keith Menear ,  Marc Hummersone ,  Xiao-ling Cockcroft ,  Mark Frigerio ,  Roger Griffin ,  Bernard Golding ,  Ian Hardcastle ,  David Newell ,  Hilary Calvert ,  Nicola Curtin ,  Marine Desage-El Murr

IPC分类号： C07D413/00

CPC分类号： C07D413/00 ,  C07D401/14 ,  C07D405/04 ,  C07D407/04 ,  C07D407/14 ,  C07D409/04 ,  C07D471/04

摘要： Compounds of formula l: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; are disclosed for use in inhibiting DNA-PK.

摘要翻译： 式I化合物：其中A，B和D分别选自：（i）CH，NH，C; （ii）CH，N，N;和（iii）CH，O，C; 被公开用于抑制DNA-PK。

公开(公告)号：US07696203B2

公开(公告)日：2010-04-13

申请号：US11403606

申请日：2006-04-13

申请人： Graeme Cameron Murray Smith ,  Niall Morrison Barr Martin ,  Keith Allan Menear ,  Marc Geoffrey Hummersone ,  Xiao-ling Cockcroft ,  Mark Frigerio ,  Roger John Griffin ,  Bernard Thomas Golding ,  Ian Robert Hardcastle ,  David Richard Newell ,  Hilary Alan Calvert ,  Nicola Jane Curtin ,  Kappusamy Saravanan ,  Marine Desage-El Murr

发明人： Graeme Cameron Murray Smith ,  Niall Morrison Barr Martin ,  Keith Allan Menear ,  Marc Geoffrey Hummersone ,  Xiao-ling Cockcroft ,  Mark Frigerio ,  Roger John Griffin ,  Bernard Thomas Golding ,  Ian Robert Hardcastle ,  David Richard Newell ,  Hilary Alan Calvert ,  Nicola Jane Curtin ,  Kappusamy Saravanan ,  Marine Desage-El Murr

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： C07D413/00 ,  C07D401/14 ,  C07D405/04 ,  C07D407/04 ,  C07D407/14 ,  C07D409/04 ,  C07D471/04

摘要： Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(═O), CH2 and NH are disclosed for use in inhibiting DNA-PK.

摘要翻译： 式I化合物：其中A，B和D分别选自：（i）CH，NH，C; （ii）CH，N，N; 和（iii）CH，O，C; 虚线表示适当位置的两个双键; 并且其中Z选自S，O，C（= O），CH 2和NH用于抑制DNA-PK。

公开(公告)号：US20130310411A1

公开(公告)日：2013-11-21

申请号：US13876656

申请日：2011-09-29

申请人： Marc Geoffery Hummersone ,  David Cousin ,  Mark Frigerio

发明人： Marc Geoffery Hummersone ,  David Cousin ,  Mark Frigerio

IPC分类号： C07D495/04 ,  C07D491/052

CPC分类号： C07D495/04 ,  C07D491/04 ,  C07D491/052

摘要： The present invention relates to novel acridine derivatives of formula (I), or pharmaceutically acceptable salts thereof, which are inhibitors of the telomerase enzyme function. These compounds are useful for the treatment cellular proliferation disorders, such as cancer.

摘要翻译： 本发明涉及作为端粒酶功能抑制剂的式（I）的新型吖啶衍生物或其药学上可接受的盐。 这些化合物可用于治疗细胞增殖紊乱，如癌症。

公开(公告)号：US20110130386A1

公开(公告)日：2011-06-02

申请号：US12989510

申请日：2009-04-24

申请人： Mark Frigerio ,  Heather Mary Ellen Duggan ,  Marc Geoffrey Hummersone ,  Keith Allan Menear ,  Niall Morrison Barr Martin ,  Celine Cano ,  Roger John Griffin ,  Bernard Thomas Golding ,  Ian Robert Hardcastle

发明人： Mark Frigerio ,  Heather Mary Ellen Duggan ,  Marc Geoffrey Hummersone ,  Keith Allan Menear ,  Niall Morrison Barr Martin ,  Celine Cano ,  Roger John Griffin ,  Bernard Thomas Golding ,  Ian Robert Hardcastle

IPC分类号： A61K31/551 ,  C07D413/14 ,  C07D243/06 ,  C12N5/071 ,  A61K31/5355 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D413/14 ,  C07D417/14

摘要： A compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 and RN2 are selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms.

摘要翻译： 式（I）的化合物，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与氮原子一起形成 与它们相连的任选取代的具有4至8个环原子的杂环; 并且RN1和RN2选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与它们所连接的氮原子一起形成任选取代的 具有4至8个环原子的杂环。

公开(公告)号：US20090042865A1

公开(公告)日：2009-02-12

申请号：US12175542

申请日：2008-07-18

申请人： Mark Frigerio ,  Marc Geoffrey Hummersone ,  Keith Allan Menear ,  Christine Sarah Bailey ,  Heather Mary Ellen Duggan ,  Sylvie Gomez ,  Niall Morrison Barr Martin

发明人： Mark Frigerio ,  Marc Geoffrey Hummersone ,  Keith Allan Menear ,  Christine Sarah Bailey ,  Heather Mary Ellen Duggan ,  Sylvie Gomez ,  Niall Morrison Barr Martin

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61K31/551 ,  A61P35/00 ,  C07D243/08

CPC分类号： C07D409/04 ,  C07D409/14

摘要： A compound of formula I: wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X is CH or N; n is 1 or 2; RC1 and RC2 are independently selected from H and methyl; when X is N, RX is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-20 heterocyclyl, C5-20 aryl, acyl, ester, amido and sulfonyl; and when X is CH, RX is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-20 heterocyclyl, C5-20 aryl, acyl, ester, amido, sulfonyl, amino and ether.

摘要翻译： 式I的化合物：其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以一起与氮原子一起形成 它们所连接的是具有4至8个环原子的任选取代的杂环; X是CH或N; n为1或2; RC1和RC2独立地选自H和甲基; 当X是N时，RX选自H和任选取代的C 1-7烷基，C 3-20杂环基，C 5-20芳基，酰基，酯，酰氨基和磺酰基; 当X是CH时，RX选自H和任选取代的C 1-7烷基，C 3-20杂环基，C 5-20芳基，酰基，酯，酰氨基，磺酰基，氨基和醚。