公开(公告)号：US4960456A

公开(公告)日：1990-10-02

申请号：US354329

申请日：1989-05-19

申请人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D303/22 ,  C07D303/34 ,  C07D405/06 ,  C07D521/00

CPC分类号： C07D303/22 ,  A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents a substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cyclo-alkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.

公开(公告)号：US4734126A

公开(公告)日：1988-03-29

申请号：US683891

申请日：1984-12-20

申请人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D303/22 ,  C07D303/34 ,  C07D405/06 ,  C07D521/00 ,  A61K31/41

CPC分类号： C07D303/22 ,  A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.

摘要翻译： 化合物，其中A表示氮原子或CH基团，B表示氧，硫或CH2基团，其中R表示取代的烷基，且表示取代的烷基， B代表硫的情况也代表未取代的烷基，任选取代的环烷基或任选取代的苯基，Z代表卤素原子或烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基，卤代烷硫基，任选取代的苯基， 苯氧基，任选取代的苯基烷基或任选取代的苯基烷氧基，m为0,1,2或3，其酸加成盐和金属盐络合物是新的，如上所述制备，可用作杀真菌剂和植物生长调节剂。

公开(公告)号：US4518600A

公开(公告)日：1985-05-21

申请号：US161636

申请日：1980-06-20

申请人： Graham Holmwood ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/40 ,  A01N43/54 ,  C04B35/565 ,  C07D213/30 ,  C07D239/26 ,  A61K31/505

CPC分类号： C07D213/30 ,  A01N43/40 ,  A01N43/54 ,  C04B35/565 ,  C07D239/26

摘要： 1-Phenoxy-2-pyridinyl(pyrimidinyl)-alkanols of the formula ##STR1## in which R represents alkyl, optionally substituted aryl or optionally substituted aralkyl,X represents a nitrogen atom or the CH group,Y represents halogen, alkyl, cycloalkyl, alkoxy, halogenoalkyl, alkylthio, or an optionally substituted phenyl, phenoxy, phenylalkoxy or phenylalkyl radical, andn represents 0 or an integer from 1 to 5, the Y's being selected independently of one another when n is 2, 3, 4 or 5,in the form of the free base, a salt or a metal salt complex thereof, which possess fungicidal properties.

摘要翻译： 式“IMAGE”的1-苯氧基-2-吡啶基（嘧啶基） - 链烷醇，其中R表示烷基，任选取代的芳基或任选取代的芳烷基，X表示氮原子或CH基团，Y表示卤素，烷基，环烷基， 烷氧基，卤代烷基，烷硫基或任选取代的苯基，苯氧基，苯基烷氧基或苯基烷基，n表示0或1至5的整数，当n为2,3,4或5时，Y彼此独立地选择， 以游离碱的形式，其盐或金属盐络合物具有杀真菌性能。

公开(公告)号：US4904296A

公开(公告)日：1990-02-27

申请号：US121552

申请日：1987-11-17

申请人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D303/22 ,  C07D303/34 ,  C07D405/06 ,  C07D521/00

CPC分类号： C07D303/22 ,  A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Compounds which are substituted 1-hydroxyalkylazolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group, Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.

公开(公告)号：US4797499A

公开(公告)日：1989-01-10

申请号：US895089

申请日：1986-08-11

申请人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D303/22 ,  C07D303/34 ,  C07D405/06 ,  C07D521/00 ,  C07D303/08

CPC分类号： C07D303/22 ,  A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.

摘要翻译： 化合物，其中A表示氮原子或CH基团，B表示氧，硫或CH2基团，其中R表示取代的烷基，且表示取代的烷基， B代表硫的情况也代表未取代的烷基，任选取代的环烷基或任选取代的苯基，Z代表卤素原子或烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基，卤代烷硫基，任选取代的苯基， 苯氧基，任选取代的苯基烷基或任选取代的苯基烷氧基，m为0,1,2或3，其酸加成盐和金属盐络合物是新的，如上所述制备，可用作杀真菌剂和植物生长调节剂。

公开(公告)号：US4438122A

公开(公告)日：1984-03-20

申请号：US391749

申请日：1982-06-24

申请人： Graham Holmwood ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/40 ,  A01N43/54 ,  C04B35/565 ,  C07D213/30 ,  C07D239/26 ,  A61K31/44

CPC分类号： C07D213/30 ,  A01N43/40 ,  A01N43/54 ,  C04B35/565 ,  C07D239/26

摘要： 1-Phenoxy-2-pyridinyl(pyrimidinyl)-alkanols of the formula ##STR1## in which R represents alkyl, optionally substituted aryl or optionally substituted aralkyl,X represents a nitrogen atom or the CH group,Y represents halogen, alkyl, cycloalkyl, alkoxy, halogenoalkyl, alkylthio, or an optionally substituted phenyl, phenoxy, phenylalkoxy or phenylalkyl radical, andn represents 0 or an integer from 1 to 5, the Y's being selected independently of one another when n is 2, 3, 4 or 5,in the form of the free base, a salt or a metal salt complex thereof, which possess fungicidal properties.

摘要翻译： 式“IMAGE”的1-苯氧基-2-吡啶基（嘧啶基） - 链烷醇，其中R表示烷基，任选取代的芳基或任选取代的芳烷基，X表示氮原子或CH基团，Y表示卤素，烷基，环烷基， 烷氧基，卤代烷基，烷硫基或任选取代的苯基，苯氧基，苯基烷氧基或苯基烷基，n表示0或1至5的整数，当n为2,3,4或5时，Y彼此独立地选择， 以游离碱的形式，其盐或金属盐络合物具有杀真菌性能。

公开(公告)号：US4789672A

公开(公告)日：1988-12-06

申请号：US732194

申请日：1985-05-08

申请人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

发明人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

IPC分类号： A01N20060101 ,  A01N43/20 ,  A01N43/50 ,  A01N43/64 ,  A01N43/653 ,  C07D20060101 ,  C07D233/60 ,  C07D249/08 ,  C07D301/00 ,  C07D301/02 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/20 ,  C07D303/22 ,  C07D521/00

CPC分类号： A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/22

摘要： New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.

摘要翻译： 其中R表示烷基，任选取代的环烷基或任选取代的苯基的新的1-羟乙基 - 唑衍生物，其中R表示氮原子或CH基团，Y表示 分别为-OCH 2 - ， - CH 2 CH 2 - 或-CH = CH-，Z表示卤素原子，烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基或卤代烷硫基，任选取代的苯基，任选取代的苯氧基， 任选取代的苯基烷基或任选取代的苯基烷氧基，m为0,1,2或3，其制备方法及其用作植物生长调节剂和杀真菌剂。

公开(公告)号：US4897107A

公开(公告)日：1990-01-30

申请号：US549867

申请日：1983-11-08

申请人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

发明人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

IPC分类号： A01N20060101 ,  A01N43/20 ,  A01N43/50 ,  A01N43/64 ,  A01N43/653 ,  C07D20060101 ,  C07D233/60 ,  C07D249/08 ,  C07D301/00 ,  C07D301/02 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/20 ,  C07D303/22 ,  C07D521/00

CPC分类号： A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/22

摘要： New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.

摘要翻译： 式（II）的环氧乙烷化合物，其中R代表叔丁基，异丙基，环丙基，取代的环丙基，环戊基或取代的环戊基，环己基或取代的环己基，在各种情况下，取代基选自甲基或 苯基，其任选被选自氟，氯，甲基和三氟甲基的相同或不同的取代基单取代或二取代，Y表示分组-OCH 2 - ，各Z独立地选自氟，氯或溴原子， 甲基，叔丁基，环己基，甲氧基，甲硫基，三氟甲基，三氟甲氧基，三氟甲硫基，苯基，苯氧基，苄基和苄氧基，所述苯基，苯氧基，苄基和苄氧基任选被相同或不同的选自氟， 氯和甲基，m为0,1,2或3; 这些化合物特别可用作农业组合物中用作植物生长调节剂的化合物的中间体。

公开(公告)号：US4871390A

公开(公告)日：1989-10-03

申请号：US732193

申请日：1985-05-08

申请人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

发明人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

IPC分类号： A01N20060101 ,  A01N43/20 ,  A01N43/50 ,  A01N43/64 ,  A01N43/653 ,  C07D20060101 ,  C07D233/60 ,  C07D249/08 ,  C07D301/00 ,  C07D301/02 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/20 ,  C07D303/22 ,  C07D521/00

CPC分类号： A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/22

摘要： A 1-Hydroxyethyl-azole compound of the formula ##STR1## wherein R is an alkyl radical with 1 to 4 carbon atoms; a cycloalkyl radical which has 3 to 7 carbon atoms and is optionally substituted by alkyl with 1 or 2 carbon atoms or a phenyl radical which is optionally substituted by halogen, alkyl with 1 to 4 carbon atoms or haloalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms; or else is phenyl which is optionally mono- or di-substituted by identical or different substituents selected form fluorine, chlorine, methyl and trifluoromethylX is --CH--;Y is a grouping --OCH.sub.2 --;Z is a halogen atom an alkyl radical with 1 to 4 carbon atoms; a cycloalkyl radical with 5 to 7 carbon atoms, an alkoxy radical with 1 to 4 carbon atoms, an alkylthio radical with 1 to 4 carbon atoms, a haloalkyl radical 1 or 2 carbon atoms and 1 to 5 halogen atoms, a haloalkoxy radical with 1 or 2 carbon atoms and 1 to 5 halogen atoms, a haloalkylthio radical with 1 or 2 carbon atoms and 1 to 5 halogen atoms, a phenyl radical which is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms, a phenoxy radical which is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms, a phenylalkyl radical which has 1 or 2 carbon atoms in the alkyl part and is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms, or a phenylalkoxy radical which has 1 or 2 carbon atoms in the alkoxy part and is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms; andm is 0, 1, 2 or 3and physiologically acceptable acid addition salts thereof or metal salt complexes thereof. Such compound being useful as a plant growth regulant and a fungicide.

摘要翻译： 式（I）的1-羟基乙基 - 唑化合物，其中R是具有1至4个碳原子的烷基; 具有3至7个碳原子并且任选被具有1或2个碳原子的烷基取代的环烷基或任选被卤素取代的苯基，具有1至4个碳原子的烷基或具有1或2个碳原子的卤代烷基和1 至5个卤素原子; 或者是任选地被选自氟，氯，甲基和三氟甲基的相同或不同取代基单取代或二取代的苯基，是-CH-; Y是一个分组-OCH2-; Z是卤原子，具有1至4个碳原子的烷基; 具有5至7个碳原子的环烷基，具有1至4个碳原子的烷氧基，具有1至4个碳原子的烷硫基，1或2个碳原子的卤代烷基，1至5个卤原子，卤代烷氧基与1 或2个碳原子和1至5个卤素原子，具有1或2个碳原子和1至5个卤素原子的卤代烷硫基，任选被卤素或具有1至4个碳原子的烷基取代的苯基，苯氧基是 任选地被卤素或具有1至4个碳原子的烷基取代，在烷基部分中具有1或2个碳原子并且任选被卤素或具有1至4个碳原子的烷基取代的苯基烷基或具有1或4个碳原子的苯基烷氧基， 烷氧基部分中的2个碳原子，任选被卤素或具有1至4个碳原子的烷基取代; 和m为0,1,2或3及其生理学上可接受的酸加成盐或其金属盐络合物。 这种化合物可用作植物生长调节剂和杀真菌剂。

公开(公告)号：US4626595A

公开(公告)日：1986-12-02

申请号：US695610

申请日：1985-01-28

申请人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

发明人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

IPC分类号： A01N20060101 ,  A01N43/20 ,  A01N43/50 ,  A01N43/64 ,  A01N43/653 ,  C07D20060101 ,  C07D233/60 ,  C07D249/08 ,  C07D301/00 ,  C07D301/02 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/20 ,  C07D303/22 ,  C07D521/00

CPC分类号： A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/22

摘要： According to the present invention 1-hydroxyethyl azole compounds are provided for in a process characterized by reacting an oxirane of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3, with an azole of the general formula ##STR2## in which X represents a nitrogen atom or a CH group.

摘要翻译： 根据本发明，提供1-羟乙基唑化合物，其特征在于使通式为“IMAGE”的环氧乙烷与其中R表示烷基，任选取代的环烷基或任选取代的苯基反应， 分组-OCH 2 - ， - CH 2 CH 2 - 或-CH = CH-，Z表示卤素原子，烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基或卤代烷硫基，任选取代的苯基，任选取代的苯氧基， 任选取代的苯基烷基或任选取代的苯基烷氧基，m为0,1,2或3，其中X表示氮原子或CH基团，通式为“IMAGE”的唑类。