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    Epoxidation process
    2.
    发明授权
    Epoxidation process 有权
    环氧化工艺

    公开(公告)号：US08664412B2

    公开(公告)日：2014-03-04

    申请号：US13811283

    申请日：2011-07-14

    申请人： Jan-Karel Frederik Buijink

    发明人： Jan-Karel Frederik Buijink

    IPC分类号： C07D301/02

    CPC分类号： C07D303/02 ,  B01J21/06 ,  B01J37/0201 ,  B01J37/0213 ,  B01J37/0238 ,  B01J37/10 ,  B01J2229/32 ,  B01J2229/36

    摘要： The present invention relates to an epoxidation process for the preparation of alkylene oxide comprising contacting a hydroperoxide with an olefin in the presence of a catalyst, wherein the catalyst is a titanium containing catalyst obtainable by a method comprising the steps of (a) making a support by a method comprising reacting a silicate with water in the presence of a surfactant selected from block copolymers based on ethylene oxide (EO) and propylene oxide (PO), and calcining the obtained reaction product; and (b) impregnating the support of step (a) with a titanium containing agent.

    摘要翻译： 本发明涉及用于制备环氧烷的环氧化方法，包括在催化剂存在下使氢过氧化物与烯烃接触，其中催化剂是含钛催化剂，其可通过以下方法获得，所述方法包括以下步骤：（a） 通过包括在选自基于环氧乙烷（EO）和环氧丙烷（PO）的嵌段共聚物的表面活性剂存在下使硅酸盐与水反应的方法，并煅烧所得反应产物; 和（b）用含钛剂浸渍步骤（a）的载体。

    Hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers
    3.
    发明授权
    Hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers 有权
    腙基和肟基荧光和发色/前荧光和原色发色试剂和接头

    公开(公告)号：US08541555B2

    公开(公告)日：2013-09-24

    申请号：US11787932

    申请日：2007-04-18

    申请人： David A. Schwartz ,  Leopoldo Mendoza

    发明人： David A. Schwartz ,  Leopoldo Mendoza

    IPC分类号： C07K16/00 ,  C07H21/04 ,  C07D235/02

    CPC分类号： G01N33/582 ,  C07D303/02

    摘要： Conjugationally extended hydrazine compositions of the formula (RR2)N(H)n(NH2)n, fluorescent hydrazone compositions of the formula (RR2)NN═C(R1R2), methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls and methods of their use in assays systems are described. Use of these conjugationally extended hydrazine and oxime compositions for direct calorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule. More specifically the linker comprises one molecule of a high affinity binding pair such as for example biotin of the biotin/avidin high affinity binding pair, connected to a spacer molecule such as for example a length of polyethyleneglycol followed by a pro-chromophoric, chromophoric, pro-fluorescent or fluorescent moiety connected to an amino-, thiol- or carbohydrate-reactive moiety such as for example succinimidyl, maleimido or aminoxy group respectively, that may covalently link to a biomolecule.

    摘要翻译： 式（RR2）N（H）n（NH2）n的共轭延伸的肼组合物，式（RR2）NN = C（R1R2）的荧光腙组合物，从共轭延伸的肼与 描述了缀合扩展的羰基及其在测定系统中的用途。 使用这些共轭延伸的肼和肟组合物用于直接量热和荧光测定，其中发色团或荧光团被引入位于反应性连接部分和生物素分子之间的连接体中。 更具体地，接头包含一个高亲和力结合对分子，例如生物素/抗生物素蛋白高亲和力结合对的生物素，连接到间隔分子，例如长度的聚乙二醇，随后是发色团，发色团， 分别连接到可以共价连接到生物分子的氨基，硫醇或碳水化合物反应性部分的前荧光或荧光部分，例如琥珀酰亚胺基，马来酰亚胺基或氨氧基。

    Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof
    5.
    发明授权
    Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof 失效
    2型甲硫氨酸氨基肽酶（MetAP2）抑制剂及其用途

    公开(公告)号：US06566541B2

    公开(公告)日：2003-05-20

    申请号：US09813555

    申请日：2001-03-21

    申请人： Jun O. Liu ,  Eric C. Griffith ,  Zhuang Su

    发明人： Jun O. Liu ,  Eric C. Griffith ,  Zhuang Su

    IPC分类号： C07D30308

    CPC分类号： C07D495/04 ,  C07D303/02 ,  C07D303/14

    摘要： Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.

    摘要翻译： 描述了抗血管生成或免疫抑制的新型化合物。 还描述了用于确定动物是否处于涉及异常血管发生的疾病或导致病理学的免疫反应的风险的方法，包括评估MetAP2代谢或结构的一个方面; 用于鉴定抗血管生成或免疫抑制剂的试剂的方法，包括评估试剂在MetAP2代谢方面的作用; 用于治疗MetAP2的代谢异常或结构异常的细胞的方法; 以及用于治疗导致动物病理学的异常血管生成或免疫反应的方法。 还提供药物组合物。

    Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof
    6.
    发明申请
    Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof 失效
    2型甲硫氨酸氨基肽酶（MetAP2）抑制剂及其用途

    公开(公告)号：US20010034455A1

    公开(公告)日：2001-10-25

    申请号：US09813555

    申请日：2001-03-21

    发明人： Jun O. Liu ,  Eric C. Griffith ,  Zhuang Su

    IPC分类号： C07D303/36

    CPC分类号： C07D495/04 ,  C07D303/02 ,  C07D303/14

    摘要： Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.

    摘要翻译： 描述了抗血管生成或免疫抑制的新型化合物。 还描述了用于确定动物是否处于涉及异常血管发生的疾病或导致病理学的免疫反应的风险的方法，包括评估MetAP2代谢或结构的一个方面; 用于鉴定抗血管生成或免疫抑制剂的试剂的方法，包括评估试剂在MetAP2代谢方面的作用; 用于治疗MetAP2的代谢异常或结构异常的细胞的方法; 以及用于治疗导致动物病理学的异常血管生成或免疫反应的方法。 还提供药物组合物。

    Oxirane compounds
    9.
    发明授权
    Oxirane compounds 失效
    环氧乙烷化合物

    公开(公告)号：US4532341A

    公开(公告)日：1985-07-30

    申请号：US499679

    申请日：1983-06-06

    申请人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

    发明人： Graham Holmwood ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes

    IPC分类号： A01N20060101 ,  A01N43/20 ,  A01N43/50 ,  A01N43/64 ,  A01N43/653 ,  C07D20060101 ,  C07D233/60 ,  C07D249/08 ,  C07D301/00 ,  C07D301/02 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/20 ,  C07D303/22 ,  C07D521/00

    CPC分类号： A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/22

    摘要： Oxirane compounds of the formula ##STR1## in which R represents tert-butyl, iso-propyl radical, cyclopropyl, substituted cyclopropyl, cyclopentyl or substituted cyclopentyl, cyclohexyl or substituted cyclohexyl, in each case the substituent being selected from methyl, or phenyl which is optionally mono or di-substituted by identical or different substituents selected from fluorine, chlorine, methyl and trifluoromethyl,Y represents a grouping --OCH.sub.2 --, each Z is individually selected from the group consisting of a fluorine, chlorine or bromine atom, methyl, tert-butyl, cyclohexyl, methoxy, methylthio, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, phenyl, phenoxy, benzyl and benzyloxy, said phenyl, phenoxy, benzyl and benzyloxy being optionally mono or di-substituted by identical or different substituents selected from fluorine, chlorine and methyl,m is 0, 1, 2 or 3; these compounds are particularly useful as intermediates for compounds used in agricultural compositions as plant growth regulants.

    摘要翻译： 式（II）的环氧乙烷化合物，其中R代表叔丁基，异丙基，环丙基，取代的环丙基，环戊基或取代的环戊基，环己基或取代的环己基，在各种情况下，取代基选自甲基或 苯基，其任选被选自氟，氯，甲基和三氟甲基的相同或不同的取代基单取代或二取代，Y表示分组-OCH 2 - ，各Z独立地选自氟，氯或溴原子， 甲基，叔丁基，环己基，甲氧基，甲硫基，三氟甲基，三氟甲氧基，三氟甲硫基，苯基，苯氧基，苄基和苄氧基，所述苯基，苯氧基，苄基和苄氧基任选被相同或不同的选自氟， 氯和甲基，m为0,1,2或3; 这些化合物特别可用作农业组合物中用作植物生长调节剂的化合物的中间体。