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公开(公告)号：US06348472B1
公开(公告)日：2002-02-19
申请号：US09586146
申请日：2000-06-02
IPC分类号： C07D47110
CPC分类号： C07D471/10
摘要： A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of spiroisoquinolinone derivatives of Formula I. As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
摘要翻译： 已经合成了一系列NPY的非肽能拮抗剂，并且由式I的螺异喹啉酮衍生物组成。作为NPY诱导的进食行为的拮抗剂，这些化合物和已知的类似物被期望作为有效的厌氧剂来促进体重减轻和治疗 饮食失调。
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公开(公告)号：US6054590A
公开(公告)日：2000-04-25
申请号：US261670
申请日：1999-03-03
申请人： Graham S. Poindexter , Ildiko Antal , Leah M. Giupponi , Robert H. Stoffel , Kevin Gillman , Mendi Higgins
发明人： Graham S. Poindexter , Ildiko Antal , Leah M. Giupponi , Robert H. Stoffel , Kevin Gillman , Mendi Higgins
IPC分类号： A61K31/4164 , A61K31/4166 , A61K31/4178 , A61K31/4192 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P3/04 , A61P43/00 , C07D233/70 , C07D233/72 , C07D233/74 , C07D233/76 , C07D233/78 , C07D233/84 , C07D233/86 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/10 , C07D233/32 , C07D233/48
CPC分类号： A61K31/4174 , A61K31/4166 , A61K31/4178 , C07D233/70 , C07D233/74 , C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06
摘要： A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
摘要翻译： 已经合成了一系列NPY的非肽能拮抗剂，并且由式I的咪唑啉酮化合物的苯基衍生物组成。作为NPY诱导的进食行为的拮抗剂，这些化合物和已知的类似物被期望作为促进重量的有效的厌氧剂 损失和治疗饮食失调。
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