Use of Myxoma virus for the therapeutic treatment of cancer and chronic viral infection
    1.
    发明授权
    Use of Myxoma virus for the therapeutic treatment of cancer and chronic viral infection 有权
    使用粘液瘤病毒治疗癌症和慢性病毒感染

    公开(公告)号:US08227440B2

    公开(公告)日:2012-07-24

    申请号:US12549939

    申请日:2009-08-28

    IPC分类号: A61K48/00 A01N65/00

    CPC分类号: A61K35/768 C12N2710/24032

    摘要: The present invention relates to therapeutic use of Myxoma virus. Myxomas virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.

    摘要翻译: 本发明涉及粘液瘤病毒的治疗用途。 粘液瘤病毒可以选择性感染具有缺陷先天性抗病毒反应的细胞,包括对干扰素无反应的细胞,可用于治疗特征在于存在这种细胞(包括癌症)的疾病。

    USE OF MYXOMA VIRUS FOR THE THERAPEUTIC TREATMENT OF CANCER AND CHRONIC VIRAL INFECTION
    2.
    发明申请
    USE OF MYXOMA VIRUS FOR THE THERAPEUTIC TREATMENT OF CANCER AND CHRONIC VIRAL INFECTION 有权
    用于治疗癌症和慢性病毒感染的MYXOMA病毒的使用

    公开(公告)号:US20090317362A1

    公开(公告)日:2009-12-24

    申请号:US12549939

    申请日:2009-08-28

    IPC分类号: A61K35/76 A61P31/12

    CPC分类号: A61K35/768 C12N2710/24032

    摘要: The present invention relates to therapeutic use of Myxoma virus. Myxomas virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.

    摘要翻译: 本发明涉及粘液瘤病毒的治疗用途。 粘液瘤病毒可以选择性感染具有缺陷先天性抗病毒反应的细胞,包括对干扰素无反应的细胞,可用于治疗特征在于存在这种细胞(包括癌症)的疾病。

    Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection
    3.
    发明授权
    Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection 失效
    使用粘液瘤病毒治疗癌症和慢性病毒感染

    公开(公告)号:US07582614B2

    公开(公告)日:2009-09-01

    申请号:US10547859

    申请日:2004-03-08

    IPC分类号: A61K31/70 C12N7/00

    CPC分类号: A61K35/768 C12N2710/24032

    摘要: The present invention relates to therapeutic use of Myxoma virus. Myxoma virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.

    摘要翻译: 本发明涉及粘液瘤病毒的治疗用途。 粘液瘤病毒可以选择性感染具有缺陷先天性抗病毒反应的细胞,包括对干扰素无反应的细胞,并可用于治疗特征在于存在这种细胞(包括癌症)的疾病。

    NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR IMMUNE MODULATION
    6.
    发明申请
    NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR IMMUNE MODULATION 有权
    核酸分子和多肽用于免疫调节

    公开(公告)号:US20110064757A1

    公开(公告)日:2011-03-17

    申请号:US12437426

    申请日:2009-05-07

    摘要: The invention provides gp38 polypeptides, which play a role in immunomodulation, nucleic acid molecules encoding these polypeptides, and therapeutic and diagnostic methods employing these polypeptides and nucleic acid molecules. The invention also provides methods for identifying compounds that modulate the biological activities of gp38 nucleic acid molecules and polypeptides, and therapeutic methods employing these compounds.

    摘要翻译: 本发明提供了在免疫调节中起作用的gp38多肽,编码这些多肽的核酸分子,以及使用这些多肽和核酸分子的治疗和诊断方法。 本发明还提供鉴定调节gp38核酸分子和多肽的生物学活性的化合物的方法,以及使用这些化合物的治疗方法。

    Chemokine binding protein and methods of use therefor
    8.
    发明授权
    Chemokine binding protein and methods of use therefor 失效
    趋化因子结合蛋白及其使用方法

    公开(公告)号:US06495515B1

    公开(公告)日:2002-12-17

    申请号:US09395554

    申请日:1999-09-14

    IPC分类号: C61K3816

    摘要: The present invention provides a method of use for a novel type I chemokine binding protein encoded by poxviruses and having amino acid sequence homology with the myxoma virus T7 interferon-&ggr; receptor homolog against disease syndromes associated with acute or chronic dysregulated inflammatory responses.

    摘要翻译: 本发明提供了一种用于由痘病毒编码的新型I型趋化因子结合蛋白的方法,其与针对与急性或慢性失调性炎症反应相关的疾病综合征的粘液瘤病毒T7干扰素-γ受体同源物具有氨基酸序列同源性。

    Nucleic acid molecules and polypeptides for immune modulation
    9.
    发明授权
    Nucleic acid molecules and polypeptides for immune modulation 有权
    用于免疫调节的核酸分子和多肽

    公开(公告)号:US08268331B2

    公开(公告)日:2012-09-18

    申请号:US12437426

    申请日:2009-05-07

    摘要: The invention provides gp38 polypeptides, which play a role in immunomodulation, nucleic acid molecules encoding these polypeptides, and therapeutic and diagnostic methods employing these polypeptides and nucleic acid molecules. The invention also provides methods for identifying compounds that modulate the biological activities of gp38 nucleic acid molecules and polypeptides, and therapeutic methods employing these compounds.

    摘要翻译: 本发明提供了在免疫调节中起作用的gp38多肽,编码这些多肽的核酸分子,以及使用这些多肽和核酸分子的治疗和诊断方法。 本发明还提供鉴定调节gp38核酸分子和多肽的生物学活性的化合物的方法,以及使用这些化合物的治疗方法。