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公开(公告)号：US07345189B2
公开(公告)日：2008-03-18
申请号：US11392909
申请日：2006-03-30
IPC分类号： C07C69/76
CPC分类号： C07C51/412 , C07C51/02 , C07C67/343 , C07C2603/74 , C07C65/26 , C07C69/94
摘要： A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; comprising the reaction between a compound of formula (II) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl, aryl, aryl-C1-C8 alkyl, or R1 and R2, taken together, form a —(CH2)m—V—(CH2)n— group, in which V is NR3 or C(R3)2 wherein R3 is hydrogen, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which R4 and R5 are independently C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C1-C8 alkyl, aryl or aryl-C1-C8 alkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.
摘要翻译： 制备式（I）化合物或其盐的方法，其中R为H，C 1 -C 8烷基，芳基或芳基-C C 1 -C 8烷基; 包括其中R 1和R 2独立地是氢，C 1 -C 8的式（II）化合物之间的反应 烷基，芳基，芳基-C 1 -C 8烷基或R 1和R 2
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公开(公告)号：US20060229465A1
公开(公告)日：2006-10-12
申请号：US11392909
申请日：2006-03-30
IPC分类号： C07C69/76
CPC分类号： C07C51/412 , C07C51/02 , C07C67/343 , C07C2603/74 , C07C65/26 , C07C69/94
摘要： A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; comprising the reaction between a compound of formula (II) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl, aryl, aryl-C1-C8 alkyl, or R1 and R2, taken together, form a —(CH2)m—V—(CH2)n— group, in which V is NR3 or C(R3)2 wherein R3 is hydrogen, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which R4 and R5 are independently C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C1-C8 alkyl, aryl or aryl-C1-C8 alkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.
摘要翻译： 制备式（I）化合物或其盐的方法，其中R为H，C 1 -C 8烷基，芳基或芳基-C C 1 -C 8烷基; 包括其中R 1和R 2独立地是氢，C 1 -C 8的式（II）化合物之间的反应 烷基，芳基，芳基-C 1 -C 8烷基或R 1和R 2
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公开(公告)号：US20050131040A1
公开(公告)日：2005-06-16
申请号：US11010455
申请日：2004-12-14
IPC分类号： A61K31/4178 , A61P9/04 , A61P9/12 , A61P25/22 , A61P27/06 , A61P43/00 , C07D403/10 , A61K31/4184
CPC分类号： C07D403/10
摘要： A process for the preparation of crystalline losartan potassium and crystalline hydrate losartan potassium.
摘要翻译： 一种制备结晶氯沙坦钾和结晶水合氯沙沙坦钾的方法。
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4.发明授权Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group 失效制备含亚磺酰基或磺酰基的有机化合物的方法公开(公告)号：US06998490B2
公开(公告)日：2006-02-14
申请号：US10801608
申请日：2004-03-17
IPC分类号： C07C317/02
CPC分类号： C07D401/12 , C07C315/02 , C07C317/44
摘要： A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.
摘要翻译： 通过用氧化量的ε-邻苯二甲酰亚氨基己酸处理硫醚或亚砜，将硫醚氧化成亚砜或砜或将亚砜氧化成砜的方法特别适用于制备工业上有用的化合物，特别是用于 人类或兽医用途。
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公开(公告)号：US20050090672A1
公开(公告)日：2005-04-28
申请号：US10969354
申请日：2004-10-21
IPC分类号： A61K31/4178 , A61P9/12 , C07C237/06 , C07C237/20 , C07D233/54 , C07D233/60 , C07D233/68 , C07D233/70 , C07D403/10
CPC分类号： C07D233/70 , C07C237/06 , C07D233/68 , C07D403/10
摘要： A process for the preparation of benzylimidazole derivatives useful as intermediates for preparation of losartan, novel intermediates for their preparation and a process for the preparation of losartan.
摘要翻译： 制备用作制备氯沙坦的中间体的苄基咪唑衍生物的制备方法，其制备的新型中间体和氯沙坦的制备方法。
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公开(公告)号：US08203002B2
公开(公告)日：2012-06-19
申请号：US12776588
申请日：2010-05-10
IPC分类号： C07D277/82
CPC分类号： C07D277/82
摘要： Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
摘要翻译： 可用于制备普拉克索的中间体及其在此类合成中的应用。
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公开(公告)号：US07741490B2
公开(公告)日：2010-06-22
申请号：US10593269
申请日：2005-03-11
IPC分类号： C07D277/82
CPC分类号： C07D277/82
摘要： Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
摘要翻译： 可用于制备普拉克索的中间体及其在此类合成中的应用。
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公开(公告)号：US07385062B2
公开(公告)日：2008-06-10
申请号：US10567492
申请日：2004-07-30
申请人： Graziano Castaldi , Pietro Allegrini , Gabriele Razzetti , Alberto Bologna , Marcello Rasparini , Vittorio Lucchini
发明人： Graziano Castaldi , Pietro Allegrini , Gabriele Razzetti , Alberto Bologna , Marcello Rasparini , Vittorio Lucchini
IPC分类号： C07D257/04
CPC分类号： C07D257/04 , C07F3/02
摘要： A process for the preparation of phenyltetrazole derivatives of formula (II) wherein R and Y are as defined in the disclosure, by direct ortho-metallation of (tetrazol-5-γl)benzene. The compounds of formula (II) are useful intermediates for the preparation of angiotensin II antagonists.
摘要翻译： 制备式（II）的苯基四唑衍生物的方法，其中R和Y如本公开所定义，通过（四唑-5-基）苯的直接邻金属化。 式（II）化合物是制备血管紧张素II拮抗剂的有用的中间体。
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公开(公告)号：US20070191439A1
公开(公告)日：2007-08-16
申请号：US10593269
申请日：2005-03-11
IPC分类号： A61K31/428 , C07D277/82
CPC分类号： C07D277/82
摘要： Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
摘要翻译： 可用于制备普拉克索的中间体及其在此类合成中的应用。
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公开(公告)号：US20060183916A1
公开(公告)日：2006-08-17
申请号：US10567492
申请日：2004-07-30
申请人： Graziano Castaldi , Pietro Allegrini , Gabriele Razzetti , Alberto Bologna , Marcello Rasparini , Vittorio Lucchini
发明人： Graziano Castaldi , Pietro Allegrini , Gabriele Razzetti , Alberto Bologna , Marcello Rasparini , Vittorio Lucchini
IPC分类号： C07D403/02
CPC分类号： C07D257/04 , C07F3/02
摘要： A process for the preparation of phenyltetrazole derivatives of formula (II) wherein R and Y are as defined in the disclosure, by direct ortho-metallation of (tetrazol-5-γl)benzene. The compounds of formula (II) are useful intermediates for the preparation of angiotensin II antagonists.
摘要翻译： 制备式（II）的苯基四唑衍生物的方法，其中R和Y如本公开所定义，通过（四唑-5-基）苯的直接邻金属化。 式（II）化合物是制备血管紧张素II拮抗剂的有用的中间体。
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