公开(公告)号：US6082990A

公开(公告)日：2000-07-04

申请号：US24910

申请日：1998-02-17

Applicant: Gregg A. Jackson ,  Stephen A. Morales

Inventor： Gregg A. Jackson ,  Stephen A. Morales

IPC: A61F2/82 ,  A61F2/06 ,  A61F2/84 ,  B29C55/22

CPC classification number: A61F2/958 ,  A61F2002/9522 ,  Y10S425/005 ,  Y10T29/49929 ,  Y10T29/53996

Abstract: A stent crimping tool for firmly and uniformly crimping a stent onto a balloon catheter. The stent crimping tool is constructed of three orthogonally arranged semi-circular shaped cams rotatably mounted on a common base. Two cams are disposed horizontally side-by-side and one cam is vertically disposed. Rotation of the three cams is synchronized by interacting racks on each cam. A groove is formed into the outer circumference of each cam and the three cams are arranged on the base, which also includes a groove, to collectively form an axial space in which a stent-catheter assembly is inserted. Rotation of the cams draws the uncrimped stent and catheter into the axial space in which the stent is crimped onto the balloon catheter by the compressive forces exerted by the grooves of the cams and the base.

Abstract translation: 一种用于将支架牢固且均匀地卷曲到气囊导管上的支架压接工具。 支架压接工具由可旋转地安装在公共基座上的三个正交布置的半圆形凸轮构成。 两个凸轮水平并排配置，一个凸轮垂直设置。 三个凸轮的旋转通过每个凸轮上的相互作用的支架进行同步。 凹槽形成在每个凸轮的外圆周中，并且三个凸轮布置在基座上，该底座还包括凹槽，以共同形成支架 - 导管组件插入其中的轴向空间。 凸轮的旋转将未标记的支架和导管通过由凸轮和底座的凹槽施加的压缩力将支架压接在气囊导管上的轴向空间中。

公开(公告)号：US06738651B1

公开(公告)日：2004-05-18

申请号：US10194111

申请日：2002-07-11

Applicant: Gregg A. Jackson

Inventor： Gregg A. Jackson

IPC: A61B500

CPC classification number: A61B5/14546 ,  A61B1/042 ,  A61B5/1459

Abstract: A medical diagnostic apparatus including a catheter and a probe assembly coupled to the catheter and a method involving the use of a catheter and a probe assembly coupled to the catheter. The probe assembly is capable of detecting a chemical analyte. The probe assembly includes a detection probe located within the catheter. The detection probe can be fixedly attached to the catheter or slideable within the catheter.

Abstract translation: 包括导管和耦合到导管的探针组件的医学诊断装置以及涉及使用与导管连接的导管和探针组件的方法。 探针组件能够检测化学分析物。 探针组件包括位于导管内的检测探针。 检测探头可以固定地连接到导管或在导管内滑动。

公开(公告)号：US06605062B1

公开(公告)日：2003-08-12

申请号：US09389159

申请日：1999-09-02

Applicant: Bridget A. Hurley ,  Jenny E. Tsien ,  David Chi ,  Gregg A. Jackson ,  Steven James Bigus

Inventor： Bridget A. Hurley ,  Jenny E. Tsien ,  David Chi ,  Gregg A. Jackson ,  Steven James Bigus

IPC: A61M5178

CPC classification number: A61M25/104 ,  A61M2025/0183 ,  A61M2025/0188

Abstract: A catheter and method of using same for support or exchange of a guidewire during a percutaneous procedure which has at least one lumen in an elongate shaft with a proximal port and a distal port in fluid communication via an inner lumen. The catheter has a longitudinal slit in the inner lumen beginning at the proximal end of the elongate shaft and extends distally. An elongate support member is secured to the elongate shaft to provide axial rigidity to the catheter. Optionally, a second inner lumen is disposed within the elongate shaft adjacent the aforementioned inner lumen which has an intermediate port disposed distally of the proximal end of the elongate shaft.

Abstract translation: 一种导管及其使用方法，用于在经皮操作过程中支撑或更换导丝，所述经皮操作在细长轴中具有至少一个内腔，其具有经由内腔流体连通的近端口和远端口。 导管在内腔中具有纵向切口，从细长轴的近端开始并向远端延伸。 细长的支撑构件固定到细长轴以向导管提供轴向刚性。 可选地，第二内腔设置在细长轴内，邻近上述内腔，该内腔具有远离细长轴近端的中间端口。

公开(公告)号：US06585755B2

公开(公告)日：2003-07-01

申请号：US09897719

申请日：2001-06-29

Applicant: Gregg A. Jackson ,  Stephen D. Pacetti

Inventor： Gregg A. Jackson ,  Stephen D. Pacetti

IPC: A61F206

CPC classification number: A61L31/18 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0098 ,  G01R33/285

Abstract: An endovascular implant, stent or other medical device formed from a polymeric material, compounded with one or more materials to render the stent visible under both magnetic resonance imaging and x-ray based fluoroscopy procedures. The stent is adaptable to be placed in any body lumen and is contemplated to be a permanent or a biodegradeable implant.

Abstract translation: 由聚合物材料形成的血管外植入物，支架或其它医疗装置，其与一种或多种材料混合以使得支架在磁共振成像和基于X射线的荧光透视程序下可见。 该支架适于放置在任何体腔中，并且被设想为永久性或生物可降解植入物。

公开(公告)号：US06202272B1

公开(公告)日：2001-03-20

申请号：US09032472

申请日：1998-02-26

Applicant: Gregg A. Jackson

Inventor： Gregg A. Jackson

IPC: B23P1902

CPC classification number: A61F2/958 ,  A61F2002/9522 ,  Y10T29/53652 ,  Y10T29/53657 ,  Y10T29/539 ,  Y10T29/53909 ,  Y10T29/53987 ,  Y10T29/53996

Abstract: A device for enabling substantially uniform and tight crimping of an intravascular stent onto a balloon catheter assembly. The stent crimping device includes at least one compressible and resiliently expandable loop portion, that is expandable radially outwardly to enable supporting of the stent and catheter assembly thereon, and compressible radially inwardly to substantially uniformly and tightly crimp the stent onto the balloon catheter assembly.

Abstract translation: 一种用于使血管内支架基本均匀且紧密地卷曲到气囊导管组件上的装置。 支架压接装置包括至少一个可压缩和弹性可扩张的环部分，其可径向向外扩张，以支撑其上的支架和导管组件，并可径向向内压缩，以将支架基本均匀且紧密地卷曲到气囊导管组件上。

公开(公告)号：US20100272779A1

公开(公告)日：2010-10-28

申请号：US12791818

申请日：2010-06-01

Applicant: Gregg A. Jackson

Inventor： Gregg A. Jackson

IPC: A61F2/82 ,  A61K31/57 ,  A61K9/127 ,  A61P35/00 ,  A61P7/02 ,  A61P9/10

CPC classification number: A61L31/16 ,  A61K9/1635 ,  A61K31/201 ,  A61K31/355 ,  A61K31/57 ,  A61L31/048 ,  A61L31/10 ,  A61L2300/22 ,  A61L2300/222 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/428 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2420/00 ,  A61L2420/08

Abstract: Progesterone-containing compositions and devices that can maintain opening of a body passageway are described. One aspect of the invention provides a therapeutically effective (e.g., relaxative, anti-oxidative, anti-restenotic, anti-angiogenic, anti-neoplastic, anti-cancerous, anti-precancerous and/or anti-thrombotic) composition or formulation containing progesterone and optionally vitamin E and/or conjugated linoleic acid. Another aspect of the invention provides a drug eluting device, such as a drug eluting stent, with at least one coating layer comprising a progesterone composition that can minimize or eliminate inflammation, thrombosis, restenosis, neo-intimal hyperplasia, rupturing of vulnerable plaque, and/or other effects related to device implantation, treatment, or interaction. Other aspects of the invention provide for methods of using such compositions, formulations, and devices.

Abstract translation: 描述了含有孕酮的组合物和能够保持身体通路的开口的装置。 本发明的一个方面提供了治疗有效（例如，松弛，抗氧化，抗再狭窄，抗血管生成，抗肿瘤，抗癌，抗癌前和/或抗血栓形成）组合物或含有孕酮和 任选的维生素E和/或共轭亚油酸。 本发明的另一方面提供了药物洗脱装置，例如药物洗脱支架，其中至少一个包含孕酮组合物的包衣层可以最小化或消除炎症，血栓形成，再狭窄，新内膜增生，易损斑块的破裂，以及 /或与器件植入，治疗或相互作用相关的其他影响。 本发明的其它方面提供了使用这种组合物，制剂和装置的方法。

公开(公告)号：US06485500B1

公开(公告)日：2002-11-26

申请号：US09531740

申请日：2000-03-21

Applicant: Arkady Kokish ,  Daryush Mirzaee ,  Eric J. Penn ,  Benjamin C. Huter ,  Kent C. B. Stalker ,  Gregg A. Jackson

Inventor： Arkady Kokish ,  Daryush Mirzaee ,  Eric J. Penn ,  Benjamin C. Huter ,  Kent C. B. Stalker ,  Gregg A. Jackson

IPC: A61M2900

CPC classification number: A61M25/104 ,  A61M2025/0079 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1093 ,  A61M2025/1095

Abstract: The emboli protection system provides one or more inflatable blocking balloons for isolation of a section of a blood vessel to prevent migration of emboli from the section during an interventional procedure, and fluid infusion and evacuation ports for flushing emboli from the isolated section. One embodiment provides for a distal blocking balloon catheter, over which an interventional device can be introduced, and a proximal blocking balloon catheter to be introduced over the interventional device for isolating a portion of a blood vessel to be treated. The blocking balloons can be perforated to provide the infusion ports, and thrombolytic inflation fluid may be used to break down and dissolve thrombus and plaque in the isolated portion of the blood vessel. The interventional therapeutic device such as an angioplasty balloon catheter may be incorporated into the distal blocking balloon catheter, or the distal and blocking proximal balloon catheters can be incorporated with the interventional therapeutic device together in one device. Infusion ports may also be provided in either or both of the distal and proximal blocking catheters.

Abstract translation: 栓塞保护系统提供一个或多个可膨胀的阻塞气球，用于隔离血管的一部分，以防止在介入手术过程中栓塞从该部分移位，以及用于从隔离部分冲洗栓塞的流体输注和排出口。 一个实施例提供远端阻塞气囊导管，介入装置可以在其上引入，以及近端阻塞气囊导管，其被引入到介入装置上，用于隔离待治疗血管的一部分。 阻塞气囊可以被穿孔以提供输注口，并且可以使用溶栓膨胀流体来分解和溶解血管的孤立部分中的血栓和斑块。 诸如血管成形术气囊导管的介入治疗装置可以并入到远端阻塞气囊导管中，或者远端和阻塞近端球囊导管可以与介入治疗装置并入一个装置中。 输液口也可以设置在远端和近端阻塞导管中的一个或两者中。

公开(公告)号：US20160220738A1

公开(公告)日：2016-08-04

申请号：US15017011

申请日：2016-02-05

Applicant: Gregg A. Jackson

Inventor： Gregg A. Jackson

IPC: A61L31/16 ,  A61K31/355 ,  A61K9/16 ,  A61L31/10 ,  A61L31/04 ,  A61K31/57 ,  A61K31/201

CPC classification number: A61L31/16 ,  A61K9/1635 ,  A61K31/201 ,  A61K31/355 ,  A61K31/57 ,  A61L31/048 ,  A61L31/10 ,  A61L2300/22 ,  A61L2300/222 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/428 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2420/00 ,  A61L2420/08

Abstract: Progesterone-containing compositions and devices that can maintain opening of a body passageway are described. One aspect of the invention provides a therapeutically effective (e.g., relaxative, anti-oxidative, anti-restenotic, anti-angiogenic, anti-neoplastic, anti-cancerous, anti-precancerous and/or anti-thrombotic) composition or formulation containing progesterone and optionally vitamin E and/or conjugated linoleic acid. Another aspect of the invention provides a drug eluting device, such as a drug eluting stent, with at least one coating layer comprising a progesterone composition that can minimize or eliminate inflammation, thrombosis, restenosis, neo-intimal hyperplasia, rupturing of vulnerable plaque, and/or other effects related to device implantation, treatment, or interaction. Other aspects of the invention provide for methods of using such compositions, formulations, and devices.

公开(公告)号：US20130245570A1

公开(公告)日：2013-09-19

申请号：US13886603

申请日：2013-05-03

Applicant: Gregg A. Jackson

Inventor： Gregg A. Jackson

IPC: A61L31/16

CPC classification number: A61L31/16 ,  A61K9/1635 ,  A61K31/201 ,  A61K31/355 ,  A61K31/57 ,  A61L31/048 ,  A61L31/10 ,  A61L2300/22 ,  A61L2300/222 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/428 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2420/00 ,  A61L2420/08

Abstract: Progesterone-containing compositions and devices that can maintain opening of a body passageway are described. One aspect of the invention provides a therapeutically effective (e.g., relaxative, anti-oxidative, anti-restenotic, anti-angiogenic, anti-neoplastic, anti-cancerous, anti-precancerous and/or anti-thrombotic) composition or formulation containing progesterone and optionally vitamin E and/or conjugated linoleic acid. Another aspect of the invention provides a drug eluting device, such as a drug eluting stent, with at least one coating layer comprising a progesterone composition that can minimize or eliminate inflammation, thrombosis, restenosis, neo-intimal hyperplasia, rupturing of vulnerable plaque, and/or other effects related to device implantation, treatment, or interaction. Other aspects of the invention provide for methods of using such compositions, formulations, and devices.

Abstract translation: 描述了含有孕酮的组合物和能够保持身体通路的开口的装置。 本发明的一个方面提供了治疗有效（例如，松弛，抗氧化，抗再狭窄，抗血管生成，抗肿瘤，抗癌，抗癌前和/或抗血栓形成）组合物或含有孕酮和 任选的维生素E和/或共轭亚油酸。 本发明的另一方面提供了药物洗脱装置，例如药物洗脱支架，其中至少一个包含孕酮组合物的包衣层可以最小化或消除炎症，血栓形成，再狭窄，新内膜增生，易损斑块的破裂，以及 /或与器件植入，治疗或相互作用相关的其他影响。 本发明的其它方面提供了使用这种组合物，制剂和装置的方法。

公开(公告)号：US06527740B1

公开(公告)日：2003-03-04

申请号：US09470877

申请日：1999-12-22

Applicant: Gregg A. Jackson ,  Jenny E. Tsien ,  Vidya J. Nayak ,  Andree L. Barker

Inventor： Gregg A. Jackson ,  Jenny E. Tsien ,  Vidya J. Nayak ,  Andree L. Barker

IPC: A61M3100

CPC classification number: A61M25/1038 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/1081

Abstract: A regrooming device for a balloon catheter, comprising a tubular member having a proximal section, a distal section, and an inner lumen extending therein configured to receive a balloon of a balloon catheter; and a mandrel disposed within the inner lumen and having a proximal end configured to enter a guide wire lumen at a distal section of the balloon catheter to facilitate guiding the distal section of the catheter into the inner lumen of the regrooming device, and a distal end secured to the distal section of the tubular member.

Abstract translation: 一种用于气囊导管的重新装置，包括具有近端部分，远侧部分和延伸在其中的内腔的管状构件，构造成容纳球囊导管的球囊; 以及心轴，其设置在所述内腔内并且具有被配置为在所述气囊导管的远端部分处进入导丝管腔的近端，以便于将所述导管的远端部分引导到所述注射装置的内腔中，并且远端 固定到管状构件的远端部分。