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公开(公告)号：US5684021A
公开(公告)日：1997-11-04
申请号：US457259
申请日：1995-06-01
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07D295/13 , A61K31/535 , A61K31/54
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
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公开(公告)号：US5686483A
公开(公告)日：1997-11-11
申请号：US457422
申请日：1995-06-01
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07D295/13 , C07D207/08 , C07D403/04 , C07D403/12
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
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公开(公告)号：US5770740A
公开(公告)日：1998-06-23
申请号：US902462
申请日：1997-07-29
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
摘要翻译： 描述了新的氨基肟基，其前体及其制备方法，以及治疗抑郁症和强迫症的方法。
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公开(公告)号：US5686446A
公开(公告)日：1997-11-11
申请号：US457681
申请日：1995-06-01
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07D403/12 , C07D207/08 , C07D295/13 , C07D403/04
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
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5.发明授权
公开(公告)号：US5665756A
公开(公告)日：1997-09-09
申请号：US285668
申请日：1994-08-03
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07C251/58 , A61K31/15 , C07C233/61
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes of the formula ##STR1## wherein: a. X is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, or a group of the formula ##STR2## wherein Y is hydrogen or loweralkyl, and p is 1 or 2; b. A is a group of the formula ##STR3## c. R.sup.1 and R.sup.2 are independently hydrogen or lowerakyl; and d. m is 2 to 6 and n is 0, or 2 to 6, inclusive, serotonin reuptake inhibitors, useful for treating depression and obsessive compulsive disorders are described. Also described are precursors of and processes for the preparation of such aminoakyloximes.
摘要翻译： 新颖的式（Ia）的氨基肟类化合物其中：a。 X是氢，低级烷基，低级烷氧基，卤素，三氟甲基或下式的基团，其中Y是氢或低级烷基，p是1或2; b。 A是一个组织或低分子基团; 和d。 m为2〜6，n为0或2〜6，含有用于治疗抑郁症和强迫症的5-羟色胺再摄取抑制剂。 还描述了制备这种氨基肟基的前体和方法。
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公开(公告)号：US5696142A
公开(公告)日：1997-12-09
申请号：US456969
申请日：1995-06-01
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07D233/64
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
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公开(公告)号：US5686447A
公开(公告)日：1997-11-11
申请号：US458147
申请日：1995-06-01
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07D295/13 , A61K31/55 , C07D267/10 , C07D281/06
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
摘要翻译： 描述了新的氨基肟基，其前体及其制备方法，以及治疗抑郁症和强迫症的方法。
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公开(公告)号：US5648367A
公开(公告)日：1997-07-15
申请号：US457081
申请日：1995-06-01
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07D401/06 , C07D401/10
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
摘要翻译： 描述了新的氨基肟基，其前体及其制备方法，以及治疗抑郁症和强迫症的方法。
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9.发明授权Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists 失效可用作D4拮抗剂的苯并异恶唑基 - ，吡啶并恶唑基和苯并噻吩基 - 苯氧基衍生物公开(公告)号：US07253165B2
公开(公告)日：2007-08-07
申请号：US10844245
申请日：2004-05-12
申请人： Gregory M. Shutske , James A. Hendrix , John G. Jurcak , Brian S. Freed , Nicholas J. Hrib , John D. Tomer, IV , Reda G. Hanna
发明人： Gregory M. Shutske , James A. Hendrix , John G. Jurcak , Brian S. Freed , Nicholas J. Hrib , John D. Tomer, IV , Reda G. Hanna
IPC分类号： C07D498/02 , A61K31/5377 , A61K31/496
CPC分类号： C07D261/20 , C07D333/56 , C07D409/12 , C07D413/12 , C07D471/04 , C07D498/04
摘要： The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
摘要翻译： 这些化合物是苯并异恶唑基 - ，吡啶并恶唑基 - 和苯并噻吩基 - 苯氧基衍生物类，可用作D 4 N 4拮抗剂。 所述化合物可用于治疗通过抑制D 4受体介导的医学病症。 这些病症包括例如注意力缺陷多动障碍，强迫症，精神病，药物滥用，物质依赖性，帕金森病，帕金森综合征，迟发性麻痹症，杜氏综合征，行为障碍和反对性反抗障碍。 本发明的另一方面是提供药物组合物，中间体和制备所述类化合物的方法。
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10.发明授权N-hydroxy-dibenz�b,e!oxepinalkylamines, n-hydroxy-dibenz�b,e!oxepinalkanoic acid amides and related heterocyclic analogues 失效N-羟基 - 二苯并[b，e]氧基烷基胺，正羟基 - 二苯并[b，e]氧代庚酸酰胺和相关杂环类似物
公开(公告)号：US5917057A
公开(公告)日：1999-06-29
申请号：US32240
申请日：1998-02-27
申请人： Richard C. Allen , Grover C. Helsley , R. Richard L. Hamer , Brian S. Freed , John I. White , Lawrence L. Martin
发明人： Richard C. Allen , Grover C. Helsley , R. Richard L. Hamer , Brian S. Freed , John I. White , Lawrence L. Martin
IPC分类号： C07D313/12 , C07D495/04 , C07D333/74 , A61K31/335 , A61K31/38 , C07D313/00
CPC分类号： C07D495/04 , C07D313/12
摘要： This invention relates to N-hydroxy-dibenz�b,e!oxepinalkylamines, N-hydroxy-dibenz�b,e!oxepinalkanoic acid amides and related heterocyclic analogues of the formula ##STR1## where X together with the carbon atoms to which it is attached forms a benzene or thiophene ring; W and Z are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; R.sup.1 is hydrogen, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; R.sup.2 is loweralkyl, cycloalkyl, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; m is 0 or 1 and n is an integer of 0 to 4 or the pharmaceutically acceptable salts thereof. The compounds of this invention are useful as analgesics and topical antiinflammatory agents for the treatment of various dermatoses and agents for the treatment of conditions where accumulation of cyclooxygenase and/or lipoxygenase metabolites is a causative factor.
摘要翻译： 本发明涉及N-羟基 - 二苯并[b，e]氧基烷基胺，N-羟基 - 二苯并[b，e]氧代庚酸酰胺和下式的相关杂环类似物，其中X与其连接的碳原子一起形成 苯或噻吩环; W和Z独立地是氢，卤素，低级烷基或三氟甲基; R1是氢，芳基低级烷基，低级烷氧基羰基，低级烷基羰基，芳基羰基或芳基低级烷基羰基; R2是低级烷基，环烷基，芳基低级烷基，低级烷氧基羰基，低级烷基羰基，芳基羰基或芳基低级烷基羰基; m为0或1，n为0〜4的整数或其药学上可接受的盐。 本发明的化合物可用作用于治疗各种皮肤病的止痛剂和局部抗炎剂和用于治疗环氧合酶和/或脂氧合酶代谢物积累是致病因素的病症的药剂。
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