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公开(公告)号：US11817177B2
公开(公告)日：2023-11-14
申请号：US18055298
申请日：2022-11-14
IPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B25/10 , G16B20/20 , G16B5/00 , G16B40/30
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US11242569B2
公开(公告)日：2022-02-08
申请号：US16737819
申请日：2020-01-08
发明人： Helmy Eltoukhy , AmirAli Talasaz , Darya Chudova , Diana Abdueva
IPC分类号： C12Q1/6886 , G16B30/00 , C12Q1/6809 , G16B99/00 , G16B30/10 , G16B20/10 , C12Q1/6874
摘要： Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples. These methods provide improved approaches for determining baseline copy number of genetic loci within a sample, reduce variation due to features of genetic loci, sample preparation, and probe exhaustion.
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公开(公告)号：US12100482B2
公开(公告)日：2024-09-24
申请号：US18503392
申请日：2023-11-07
IPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US12094573B2
公开(公告)日：2024-09-17
申请号：US18506734
申请日：2023-11-10
IPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US11062791B2
公开(公告)日：2021-07-13
申请号：US16719768
申请日：2019-12-18
IPC分类号： C12Q1/68 , G16B30/00 , G16B5/00 , G16B40/30 , C12Q1/6806
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US11952616B2
公开(公告)日：2024-04-09
申请号：US18061898
申请日：2022-12-05
IPC分类号： C12Q1/68 , C12N15/10 , C12Q1/6806 , C12Q1/6874 , C12Q1/6886
CPC分类号： C12Q1/6806 , C12N15/1065 , C12Q1/6874 , C12Q1/6886 , C12Q2600/154
摘要： The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins). These methods accommodate multiple forms and/or modifications of nucleic acid in a sample, such that sequence information can be obtained for multiple forms. The methods also preserve the identity of multiple forms or modified states through processing and analysis, such that analysis of sequence can be combined with epigenetic analysis.
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公开(公告)号：US11817179B2
公开(公告)日：2023-11-14
申请号：US18155523
申请日：2023-01-17
IPC分类号： G16B30/00 , C12Q1/6806 , G16B40/30 , G16B20/20 , C12Q1/6827 , G16B5/00 , G16B25/10
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US20220356527A1
公开(公告)日：2022-11-10
申请号：US17552728
申请日：2021-12-16
发明人： Helmy Eltoukhy , AmirAli Talasaz , Darya Chudova , Diana Abdueva
IPC分类号： C12Q1/6886 , G16B30/00 , C12Q1/6809 , G16B99/00 , G16B30/10 , G16B20/10 , C12Q1/6874
摘要： Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples. These methods provide improved approaches for determining baseline copy number of genetic loci within a sample, reduce variation due to features of genetic loci, sample preparation, and probe exhaustion.
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公开(公告)号：US09850523B1
公开(公告)日：2017-12-26
申请号：US15426668
申请日：2017-02-07
CPC分类号： C12Q1/6806 , C12Q1/6827 , C12Q1/6869 , G06F19/20 , C12Q2527/143 , C12Q2537/143
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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