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公开(公告)号：US5395834A
公开(公告)日：1995-03-07
申请号：US225532
申请日：1994-04-11
申请人： Guillaume Le Baut , Jean-Paul Babingui , Sylvie Robert-Piessard , Pierre Renard , Daniel-Henri Caignard , Jean-Francois Renaud de la Faverie , Gerard Adam
发明人： Guillaume Le Baut , Jean-Paul Babingui , Sylvie Robert-Piessard , Pierre Renard , Daniel-Henri Caignard , Jean-Francois Renaud de la Faverie , Gerard Adam
IPC分类号： A61K31/35 , A61K31/352 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , A61K31/54 , A61P3/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D311/58 , C07D311/66 , C07D311/70 , C07D311/72 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04 , C07D498/20 , C07D403/00 , C07D413/00
CPC分类号： C07D405/12 , C07D311/66 , Y10S514/824 , Y10S514/825
摘要： A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and n are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal product containing the same for treating a mammal afflicted with a disorder connected with peroxydation processes and biosynthesis of eicosanoids.
摘要翻译： 选自式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中所定义，其光学异构体和 其与药学上可接受的酸或碱的加成盐，以及含有它们的药物，用于治疗患有与过氧化作用过程相关的病症的哺乳动物和二十烷酸的生物合成。
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公开(公告)号：US5382593A
公开(公告)日：1995-01-17
申请号：US94562
申请日：1993-07-20
申请人： Guillaume Le Baut , Marie-Renee Nourrisson , Jean-Francois Renaud de la Faverie , Jean-Guy Bizot Espiard , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Guillaume Le Baut , Marie-Renee Nourrisson , Jean-Francois Renaud de la Faverie , Jean-Guy Bizot Espiard , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/4427 , A61P3/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P25/04 , A61P29/00 , A61P37/00 , A61P37/08 , C07D209/30 , C07D209/34 , C07D401/04
CPC分类号： C07D401/04 , A61K31/40 , C07D209/30 , C07D209/34
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined in the description, its Z and E isomers, its optical isomers, in pure form or in the form of a mixture, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating a disorder resulting from or associated with peroxidation phenomena, disturbances in eicosanoid synthesis, or with platelet aggregation disorders.
摘要翻译： 本发明涉及选自式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5和X如说明书中所定义，其Z和E异构体，其旋光异构体， 其形式为混合物，其与药学上可接受的酸或碱的加成盐，以及含有该药物的药物可用于治疗由二氧化反应现象引起的或与过氧化作用有关的病症，类二十烷酸合成紊乱 ，或血小板聚集障碍。
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3.发明授权Use of benzopyran derivatives for the treatment of pathologies associated with the NA.sup.+ -independent CI-/HCO.sub.3 -exchanger 失效苯并吡喃衍生物用于治疗与NA +独立CI- / HCO3-交换器相关的病理学的用途
公开(公告)号：US5703118A
公开(公告)日：1997-12-30
申请号：US643257
申请日：1996-05-03
申请人： Ludovic Durand , Jean-Paul Babingui , Claudie Moulin , Sylvie Robert-Piessard , Guillaume Le Baut , Elisabeth Scalbert , Daniel-Henri Caignard , Pierre Renard
发明人： Ludovic Durand , Jean-Paul Babingui , Claudie Moulin , Sylvie Robert-Piessard , Guillaume Le Baut , Elisabeth Scalbert , Daniel-Henri Caignard , Pierre Renard
IPC分类号： C07D311/58 , A61K31/35 , A61K31/352 , A61K31/353 , A61P1/00 , A61P1/04 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P19/10 , A61P25/28 , A61P43/00 , C07D311/70 , C07D311/72
CPC分类号： A61K31/353 , Y10S514/925
摘要： A method of treating a mammal afflicted with a disorder associated with the Na.sup.+ -independent Cl.sup.- /HCO.sub.3 - exchanger comprising the step of administering a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and n are as defined in the description, which is effective for alleviating the said disorder.
摘要翻译： 治疗患有与Na + - 依赖性Cl- / HCO 3 - 交换体相关的病症的哺乳动物的方法包括施用选自式（I）的化合物的步骤：其中R 1，R 2， R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和n如描述中所定义，其对减轻所述病症有效。
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公开(公告)号：US5712294A
公开(公告)日：1998-01-27
申请号：US450346
申请日：1995-05-25
申请人： Jean-Michel Robert , Odile Rideau , Sylvie Robert-Piessard , Jacqueline Courant , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Jean-Michel Robert , Odile Rideau , Sylvie Robert-Piessard , Jacqueline Courant , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： C07D213/81 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/495 , A61K31/497 , A61P13/02 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/02 , A61P29/00 , C07D213/75 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
CPC分类号： C07D213/75 , C07D401/12 , C07D413/12
摘要： A compound selected from those of formula (I): ##STR1## where m is equal to 0 or 1 and Het, A, X, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and the ring ##STR2## are defined in the description, and a medicinal product comprising the same for treating an inflammatory disorder.
摘要翻译： 选自式（I）的化合物：其中m等于0或1，并且Het，A，X，R，R 1，R 2，R 3，R 4和环
定义在 描述，以及包含其的用于治疗炎性疾病的药物。 -
公开(公告)号：US5470864A
公开(公告)日：1995-11-28
申请号：US268289
申请日：1994-06-30
申请人： Muriel Duflos , Sylvie Robert-Piessard , Lucien Welin , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Muriel Duflos , Sylvie Robert-Piessard , Lucien Welin , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/44 , A61K31/4418 , A61P3/06 , A61P29/00 , C07D213/75 , C07D213/89 , C07D401/12 , C07F5/02
CPC分类号： C07D213/75 , C07D213/89 , C07D401/12 , C07F5/02 , C07F5/025
摘要： Compounds of the general formula: ##STR1## wherein m, X, Y, A, R.sub.2 and R.sub.3 are defined in the description.
摘要翻译： 通式：其中m，X，Y，A，R 2和R 3的化合物在说明书中定义。
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公开(公告)号：US5843947A
公开(公告)日：1998-12-01
申请号：US827344
申请日：1997-03-26
申请人： Jean-Michel Robert , Odile Rideau , Sylvie Robert-Piessard , Jacqueline Courant , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Jean-Michel Robert , Odile Rideau , Sylvie Robert-Piessard , Jacqueline Courant , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： C07D213/81 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/495 , A61K31/497 , A61P13/02 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/02 , A61P29/00 , C07D213/75 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
CPC分类号： C07D213/75 , C07D401/12 , C07D413/12
摘要： A compound selected from those of formula (I): ##STR1## where m is equal to 0 or 1 and Het, A, X, R,R.sub.1, R.sub.2, R.sub.3, R.sub.4 and the ring ##STR2## are defined in the description, and a medicinal product comprising the same for treating an inflammatory disorder.
摘要翻译： 选自式（I）的化合物：其中m等于0或1，并且Het，A，X，R，R 1，R 2，R 3，R 4和环
定义在 描述，以及包含其的用于治疗炎性疾病的药物。 -
公开(公告)号：US5315017A
公开(公告)日：1994-05-24
申请号：US876763
申请日：1992-05-01
申请人： Guillaume Le Baut , Jean-Paul Babingui , Jacqueline Courant , Jean-Michel Robert , Pierre Renard , Daniel-Henri Caignard , Jean-Francois R. de la Faverie , Gerard Adam
发明人： Guillaume Le Baut , Jean-Paul Babingui , Jacqueline Courant , Jean-Michel Robert , Pierre Renard , Daniel-Henri Caignard , Jean-Francois R. de la Faverie , Gerard Adam
IPC分类号： A61K31/35 , A61K31/352 , A61K31/38 , A61K31/41 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P3/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P37/08 , C07D311/58 , C07D311/66 , C07D311/70 , C07D311/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D419/12 , C07D471/04 , C07D491/107 , C07D498/10 , C07D31/04
CPC分类号： C07D405/12 , C07D311/58 , C07D311/66 , C07D311/72 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12 , C07D419/12 , C07D471/04
摘要： A compound selected from the group consisting of those of formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, X and n are defined in the description, an optical isomer thereof, and an addition salt thereof with a pharmaceutically-acceptable base or acid.Medicinal product which is useful in treating or in preventing a disorder due to or linked to the phenomena of peroxidation and to the disturbance of the eicosanoid biosynthesis.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X和n在说明书中定义，其光学异构体和 其加盐与药学上可接受的碱或酸。 可用于治疗或预防由于过氧化现象和类花生酸生物合成紊乱引起的或与之相关的病症的药用产品。
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公开(公告)号：US5585390A
公开(公告)日：1996-12-17
申请号：US437399
申请日：1995-05-09
申请人： Muriel Duflos , Sylvie Robert-Piessard , Lucien Welin , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , G erard Adam
发明人： Muriel Duflos , Sylvie Robert-Piessard , Lucien Welin , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , G erard Adam
IPC分类号： A61K31/44 , A61K31/4418 , A61P3/06 , A61P29/00 , C07D213/75 , C07D213/89 , C07D401/12 , C07F5/02
CPC分类号： C07D213/75 , C07D213/89 , C07D401/12 , C07F5/02 , C07F5/025
摘要： Compounds of the general formula: ##STR1## wherein m, X, Y, A, R.sub.2 and R.sub.3 are defined in the description, and medicaments containing the same.
摘要翻译： 通式：其中m，X，Y，A，R 2和R 3在通式中描述的化合物及含有它们的药物。
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公开(公告)号：US5889045A
公开(公告)日：1999-03-30
申请号：US977793
申请日：1997-11-25
申请人： Timothee Muller , Claudie Moulin , Muriel Duflos , Sylvie Robert-Piessard , Guillaume Le Baut , Alain Tonnerre , Daniel-Henri Caignard , Dominique Manechez , Pierre Renard
发明人： Timothee Muller , Claudie Moulin , Muriel Duflos , Sylvie Robert-Piessard , Guillaume Le Baut , Alain Tonnerre , Daniel-Henri Caignard , Dominique Manechez , Pierre Renard
IPC分类号： C07D311/58 , A61K31/35 , A61K31/352 , A61P3/08 , A61P3/10 , C07D311/66 , C07D311/72 , C07D405/12 , A61K31/355 , A61K31/47 , C07D215/36 , C07D311/04
CPC分类号： C07D405/12 , C07D311/66 , C07D311/72
摘要： A compound of formula (I): ##STR1## in which: R.sub.1 represents alkyl,R.sub.2, R.sub.4 and R.sub.5, which may be identical or different, represent hydrogen or alkyl,R.sub.3 represents any one of the groups as defined in the description,X represents carbonyl or methylene,Y represents hydrogen or alkyl or aryl,A represents single bond or alkylphenyl,R.sub.6 represents any one of the groups as defined in the description, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base,and medicinal productes containing the same are useful in the treatment of diabetes and complications of diabetic disease.
摘要翻译： 式（I）的化合物：其中：R 1表示烷基，R 2，R 4和R 5，其可以相同或不同，表示氢或烷基，R 3表示任何一个如 描述，X表示羰基或亚甲基，Y表示氢或烷基或芳基，A表示单键或烷基苯基，R6表示说明书中定义的基团中的任何一个，其异构体以及其与药学上可接受的酸的加成盐或 碱和含有该药物的药物可用于治疗糖尿病和糖尿病的并发症。
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10.发明授权Derivatives of 3-imino-1,2-dithioles, method for producing them and pharmaceutical compositions containing the same 失效3-亚氨基-1,2-二硫酚的衍生物，其制备方法和含有它们的药物组合物公开(公告)号：US06686378B2
公开(公告)日：2004-02-03
申请号：US10168875
申请日：2002-06-21
申请人： Muriel Duflos , Jean-Michel Robert , Marie-Renée Nourrisson , Guillaume Le Baut , Daniel-Henri Caignard , Jean-Guy Bizot-Espiard , Pierre Renard
发明人： Muriel Duflos , Jean-Michel Robert , Marie-Renée Nourrisson , Guillaume Le Baut , Daniel-Henri Caignard , Jean-Guy Bizot-Espiard , Pierre Renard
IPC分类号： A61K314436
CPC分类号： C07D409/14 , C07D417/14
摘要： Compound of formula (I): wherein: Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl, A represents a bond or linear or branched (C1-C6)alkylene, its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.
摘要翻译： 式（I）化合物：其中：Het1和Het2可以相同或不同，各自表示任选取代的吡啶基，A表示键或直链或支链（C1-C6）亚烷基，其光学异构体存在， 和其与药学上可接受的酸的加成盐。
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