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公开(公告)号：US08617814B2
公开(公告)日：2013-12-31
申请号：US13544303
申请日：2012-07-09
申请人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
发明人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
CPC分类号： C12Q1/6834 , C12Q1/6813 , C12Q1/6818 , C12Q1/6825 , Y10T436/143333 , C12Q2565/107 , C12Q2563/107 , C12Q2523/313
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
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2.发明授权Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权使用光收获多色素探测和分析多核苷酸的方法和组合物公开(公告)号：US08227187B2
公开(公告)日：2012-07-24
申请号：US12632734
申请日：2009-12-07
申请人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
发明人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
CPC分类号： C12Q1/6834 , C12Q1/6813 , C12Q1/6818 , C12Q1/6825 , Y10T436/143333 , C12Q2565/107 , C12Q2563/107 , C12Q2523/313
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团，并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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3.发明授权Compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权用于使用光收获多色素探测和分析多核苷酸的组合物公开(公告)号：US07629448B2
公开(公告)日：2009-12-08
申请号：US11854365
申请日：2007-09-12
申请人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
发明人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
CPC分类号： C12Q1/6834 , C12Q1/6813 , C12Q1/6818 , C12Q1/6825 , Y10T436/143333 , C12Q2565/107 , C12Q2563/107 , C12Q2523/313
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团，并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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4.发明授权Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权使用光收获多色素探测和分析多核苷酸的方法和组合物公开(公告)号：US07270956B2
公开(公告)日：2007-09-18
申请号：US10648945
申请日：2003-08-26
申请人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
发明人： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang
CPC分类号： C12Q1/6834 , C12Q1/6813 , C12Q1/6818 , C12Q1/6825 , Y10T436/143333 , C12Q2565/107 , C12Q2563/107 , C12Q2523/313
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团，并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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5.发明授权Compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权用于使用光收获多色素探测和分析多核苷酸的组合物公开(公告)号：US08101416B2
公开(公告)日：2012-01-24
申请号：US11746055
申请日：2007-05-08
CPC分类号： C12Q1/6818 , C12Q1/682 , Y10T436/143333 , C12Q2565/107 , C12Q2525/107 , C12Q2527/125
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. A signaling chromophore absorbs energy from the excited multichromophore and emits light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits having reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器PNA接触。 信号发色团从被激发的多色素吸收能量并在靶多核苷酸存在下发光。 该方法可以多路复用形式使用。 还提供了具有用于执行这些方法的试剂的试剂盒。
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6.发明授权Compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权用于使用光收获多色素探测和分析多核苷酸的组合物公开(公告)号：US09371559B2
公开(公告)日：2016-06-21
申请号：US13356500
申请日：2012-01-23
CPC分类号： C12Q1/6818 , B82Y15/00 , C12Q2525/107 , C12Q2527/125 , C12Q2565/107
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. The sensor PNA comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器PNA接触。 传感器PNA包括信号发色团，以吸收来自激发的多色素的能量并在目标多核苷酸的存在下发光。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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7.发明申请COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES 有权使用光收集多色素检测和分析多核苷酸的组合物公开(公告)号：US20080280369A1
公开(公告)日：2008-11-13
申请号：US11746055
申请日：2007-05-08
CPC分类号： C12Q1/6818 , C12Q1/682 , Y10T436/143333 , C12Q2565/107 , C12Q2525/107 , C12Q2527/125
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. The sensor PNA comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器PNA接触。 传感器PNA包括信号发色团，以吸收来自激发的多色素的能量并在目标多核苷酸的存在下发光。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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8.发明申请COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES 有权使用光收集多色素检测和分析多核苷酸的组合物公开(公告)号：US20130303388A9
公开(公告)日：2013-11-14
申请号：US13356500
申请日：2012-01-23
CPC分类号： C12Q1/6818 , B82Y15/00 , C12Q2525/107 , C12Q2527/125 , C12Q2565/107
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. The sensor PNA comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器PNA接触。 传感器PNA包括信号发色团，以吸收来自激发的多色素的能量并在目标多核苷酸的存在下发光。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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9.发明申请公开(公告)号：US20130190193A1
公开(公告)日：2013-07-25
申请号：US13356500
申请日：2012-01-23
CPC分类号： C12Q1/6818 , B82Y15/00 , C12Q2525/107 , C12Q2527/125 , C12Q2565/107
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. The sensor PNA comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
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10.发明授权Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权使用光收获多色素探测和分析多核苷酸的方法和组合物公开(公告)号：US07214489B2
公开(公告)日：2007-05-08
申请号：US10600286
申请日：2003-06-20
CPC分类号： C12Q1/6818 , C12Q1/682 , Y10T436/143333 , C12Q2565/107 , C12Q2525/107 , C12Q2527/125
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. The sensor PNA comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器PNA接触。 传感器PNA包括信号发色团，以吸收来自激发的多色素的能量并在目标多核苷酸的存在下发光。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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