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公开(公告)号：US20100323916A1
公开(公告)日：2010-12-23
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
摘要： In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.
摘要翻译： 在一个实施例中，高通量流量系统包括井的阵列和位于每个井内的单独的机械末端。 每个机械末端分别致动以赋予剪切应力模式。
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公开(公告)号：US09006149B2
公开(公告)日：2015-04-14
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
摘要： A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.
摘要翻译： 高通量流量系统包括井阵列和位于每个井内的单独机械末端。 每个机械末端分别致动以赋予剪切应力模式。 单独的套筒可以与每个尖端相关联，以保持尖端与尖端相应的井的底板之间的预定距离，每个尖端可在其对应的套筒内旋转。 或者，单独的柱可以与每个末端相关联，以保持尖端与尖端相应的井的底部之间的预定距离，其中每个尖端可围绕其相应的柱转动。
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公开(公告)号：US08876795B2
公开(公告)日：2014-11-04
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译： 一种用于在一段时间内将药物输送到患者身体的体液中的可植入药物递送设备包括：药物供应储存器，用于将药物供应到输送通道中;以及致动器，用于将药物输送到患者的预定位置 患者的身体腔，例如人耳的耳蜗。 药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。
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公开(公告)号：US20130053823A1
公开(公告)日：2013-02-28
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译： 一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括：药物供应储存器，用于将药物供给到输送通道中;以及致动器，用于将药物输送到患者的预定位置 患者的身体腔，例如人耳的耳蜗。 药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。
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5.发明授权Method and apparatus for separating particles, cells, molecules and particulates 有权用于分离颗粒，细胞，分子和颗粒的方法和装置公开(公告)号：US08292083B2
公开(公告)日：2012-10-23
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B03C1/30
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译： 一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废流体的磁场梯度，以及在流过磁场梯度之后收集每个流体流。
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6.发明申请METHOD AND APPARATUS FOR SEPARATING PARTICLES, CELLS, MOLECULES AND PARTICULATES 有权分离颗粒，细胞，分子和颗粒的方法和装置公开(公告)号：US20090078614A1
公开(公告)日：2009-03-26
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B07C5/344
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译： 一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废液流的磁场梯度，以及在流过磁场梯度之后收集每个流体流。
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公开(公告)号：US20120007778A1
公开(公告)日：2012-01-12
申请号：US12832587
申请日：2010-07-08
申请人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan McLaughlin , Frans Spaepen
发明人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan McLaughlin , Frans Spaepen
摘要： In various embodiments, an actuating mechanism is employed to displace a conductor disposed within a fluidic channel, thereby reconfiguring an electronic component.
摘要翻译： 在各种实施例中，使用致动机构来置换设置在流体通道内的导体，从而重新配置电子部件。
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8.发明申请DEVICES AND METHODS FOR PRODUCING A CONTINUOUSLY FLOWING CONCENTRATION GRADIENT IN LAMINAR FLOW 有权在层流中产生连续流动浓度梯度的装置和方法公开(公告)号：US20090044619A1
公开(公告)日：2009-02-19
申请号：US12043575
申请日：2008-03-06
申请人： Jason O. Fiering , Mathew Varghese
发明人： Jason O. Fiering , Mathew Varghese
IPC分类号： G01F5/00
CPC分类号： B01J19/0093 , B01F5/0641 , B01F13/0059 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00889 , B01L3/502776 , Y10T137/87281
摘要： The invention generally relates to combining a plurality of flow streams. In various embodiments, a first channel transports a first laminar fluid flow, a second channel transports a second laminar fluid flow, and the first and second channels enter a merging region at an acute angle to one another along separate substantially parallel planes.
摘要翻译： 本发明一般涉及组合多个流动流。 在各种实施例中，第一通道输送第一层流体流，第二通道输送第二层流体流，并且第一和第二通道沿独立的基本上平行的平面以彼此成锐角进入锐角。
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公开(公告)号：US5391269A
公开(公告)日：1995-02-21
申请号：US84689
申请日：1993-06-29
IPC分类号： H01L21/306 , G02B6/36 , H01L21/3063 , B23H3/00
CPC分类号： H01L21/3063 , Y10T29/49169
摘要： We have found that etching of a body that comprises exposed Si as well as a Ti-comprising metal layer (e.g., a patterned Ti/Pt layer) in an amine-based anisotropic etchant for Si (e.g., 100.degree. C. EDP) frequently results in undesirable changes in the Ti-comprising metal layer. We have also found that the changes can be substantially reduced or eliminated by electrolytic means, namely, by making the metal layer the anode in an electrolytic cell that contains the etchant.
摘要翻译： 我们已经发现，在基于胺的各向异性蚀刻剂（例如，100℃EDP）中经常蚀刻包括暴露的Si以及包含Ti的金属层（例如，图案化的Ti / Pt层）的主体 导致含Ti的金属层的不期望的变化。 我们还发现，通过电解方式，即通过在含有蚀刻剂的电解槽中使金属层成为阳极，可以显着地减少或消除这些变化。
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10.发明授权Electronic devices, such as antennas, having fluidic constructs that permit reconfiguration of the devices 有权电子设备，例如天线，具有允许重新配置设备的流体结构公开(公告)号：US09293821B2
公开(公告)日：2016-03-22
申请号：US12832587
申请日：2010-07-08
申请人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan Mclaughlin , Frans Spaepen
发明人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan Mclaughlin , Frans Spaepen
摘要： In various embodiments, an actuating mechanism is employed to displace a conductor disposed within a fluidic channel, thereby reconfiguring an electronic component.
摘要翻译： 在各种实施例中，使用致动机构来置换设置在流体通道内的导体，从而重新配置电子部件。
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