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公开(公告)号：US09006149B2
公开(公告)日：2015-04-14
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
摘要： A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.
摘要翻译： 高通量流量系统包括井阵列和位于每个井内的单独机械末端。 每个机械末端分别致动以赋予剪切应力模式。 单独的套筒可以与每个尖端相关联，以保持尖端与尖端相应的井的底板之间的预定距离，每个尖端可在其对应的套筒内旋转。 或者，单独的柱可以与每个末端相关联，以保持尖端与尖端相应的井的底部之间的预定距离，其中每个尖端可围绕其相应的柱转动。
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公开(公告)号：US20100323916A1
公开(公告)日：2010-12-23
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
摘要： In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.
摘要翻译： 在一个实施例中，高通量流量系统包括井的阵列和位于每个井内的单独的机械末端。 每个机械末端分别致动以赋予剪切应力模式。
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公开(公告)号：US20130004386A1
公开(公告)日：2013-01-03
申请号：US13608938
申请日：2012-09-10
申请人： Jeffrey T. Borenstein , Eli J. Weinberg , James C. Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
发明人： Jeffrey T. Borenstein , Eli J. Weinberg , James C. Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0861 , B01L2300/12 , B29C33/3857 , B29C59/02 , B29K2025/06 , B29L2031/753 , B33Y80/00 , B81B2201/058 , B81B2203/0338 , B81B2203/0376 , B81C1/00119 , B81C99/0085 , Y10T29/49126 , Y10T29/49155 , Y10T29/49156 , Y10T29/49401 , Y10T156/1039 , Y10T428/139
摘要： Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.
摘要翻译： 具有基本圆形通道的微流体结构可以通过压花聚合物片来制造。
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公开(公告)号：US20090181200A1
公开(公告)日：2009-07-16
申请号：US12234215
申请日：2008-09-19
申请人： Jeffrey T. Borenstein , Eli J. Weinberg , James C. Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
发明人： Jeffrey T. Borenstein , Eli J. Weinberg , James C. Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0861 , B01L2300/12 , B29C33/3857 , B29C59/02 , B29K2025/06 , B29L2031/753 , B33Y80/00 , B81B2201/058 , B81B2203/0338 , B81B2203/0376 , B81C1/00119 , B81C99/0085 , Y10T29/49126 , Y10T29/49155 , Y10T29/49156 , Y10T29/49401 , Y10T156/1039 , Y10T428/139
摘要： Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.
摘要翻译： 具有基本上圆形通道的微流体结构可以通过压花聚合物片来制造。
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5.发明授权公开(公告)号：US08266791B2
公开(公告)日：2012-09-18
申请号：US12234215
申请日：2008-09-19
申请人： Jeffrey T. Borenstein , Eli J. Weinberg , James Ching-Ming Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
发明人： Jeffrey T. Borenstein , Eli J. Weinberg , James Ching-Ming Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0861 , B01L2300/12 , B29C33/3857 , B29C59/02 , B29K2025/06 , B29L2031/753 , B33Y80/00 , B81B2201/058 , B81B2203/0338 , B81B2203/0376 , B81C1/00119 , B81C99/0085 , Y10T29/49126 , Y10T29/49155 , Y10T29/49156 , Y10T29/49401 , Y10T156/1039 , Y10T428/139
摘要： Methods of fabricating microfluidic structures featuring substantially circular channels are provided. The methods involve (a) providing a patterned wafer comprising at least one exposed electrically conductive region and at least one exposed electrically insulating region; (b) electroplating an inverse channel portion with substantially semicircular cross section onto the wafer, thereby forming a first master mold; (c) employing the first master mold so as to emboss a channel portion in a first polymer sheet; and (d) aligning and bonding the first polymer sheet with a second polymer sheet having a corresponding channel portion such as to define a first channel with substantially circular cross section between the polymer sheets.
摘要翻译： 提供了制造具有基本圆形通道的微流体结构的方法。 所述方法包括（a）提供包括至少一个暴露的导电区域和至少一个暴露的电绝缘区域的图案化晶片; （b）将具有基本上半圆形横截面的反向通道部分电镀到晶片上，从而形成第一主模具; （c）使用所述第一主模具以压缩第一聚合物片材中的通道部分; 和（d）将第一聚合物片材与具有对应的通道部分的第二聚合物片材对准和接合，以限定在聚合物片材之间具有基本圆形横截面的第一通道。
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公开(公告)号：US09181082B2
公开(公告)日：2015-11-10
申请号：US13608938
申请日：2012-09-10
申请人： Jeffrey T. Borenstein , Eli J. Weinberg , James C. Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
发明人： Jeffrey T. Borenstein , Eli J. Weinberg , James C. Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0861 , B01L2300/12 , B29C33/3857 , B29C59/02 , B29K2025/06 , B29L2031/753 , B33Y80/00 , B81B2201/058 , B81B2203/0338 , B81B2203/0376 , B81C1/00119 , B81C99/0085 , Y10T29/49126 , Y10T29/49155 , Y10T29/49156 , Y10T29/49401 , Y10T156/1039 , Y10T428/139
摘要： Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.
摘要翻译： 具有基本圆形通道的微流体结构可以通过压花聚合物片来制造。
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公开(公告)号：US08876795B2
公开(公告)日：2014-11-04
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译： 一种用于在一段时间内将药物输送到患者身体的体液中的可植入药物递送设备包括：药物供应储存器，用于将药物供应到输送通道中;以及致动器，用于将药物输送到患者的预定位置 患者的身体腔，例如人耳的耳蜗。 药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。
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公开(公告)号：US20130053823A1
公开(公告)日：2013-02-28
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译： 一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括：药物供应储存器，用于将药物供给到输送通道中;以及致动器，用于将药物输送到患者的预定位置 患者的身体腔，例如人耳的耳蜗。 药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。
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9.发明授权Method and apparatus for separating particles, cells, molecules and particulates 有权用于分离颗粒，细胞，分子和颗粒的方法和装置公开(公告)号：US08292083B2
公开(公告)日：2012-10-23
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B03C1/30
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译： 一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废流体的磁场梯度，以及在流过磁场梯度之后收集每个流体流。
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10.发明申请METHOD AND APPARATUS FOR SEPARATING PARTICLES, CELLS, MOLECULES AND PARTICULATES 有权分离颗粒，细胞，分子和颗粒的方法和装置公开(公告)号：US20090078614A1
公开(公告)日：2009-03-26
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B07C5/344
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译： 一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废液流的磁场梯度，以及在流过磁场梯度之后收集每个流体流。
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