专利检索 ap:("Guillermo Garcia-Cardena" OR "Peter Mack" OR "Jeffrey T. Borenstein" OR "Ahmad S. Khalil" OR "Eli J. Weinberg" OR "Jason O. Fiering" OR "Ernest S. Kim" OR "William J. Adams, Jr.") AND inv:"Ahmad S. Khalil" 第 1 页

1.

发明授权
High-throughput biological screening 有权
标题翻译：高通量生物筛选

公开(公告)号：US09006149B2

公开(公告)日：2015-04-14

申请号：US12687717

申请日：2010-01-14

申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.

发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.

IPC分类号： C40B30/06 , C40B60/12 , C12M1/32 , C12M1/42

CPC分类号： C12M23/12 , C12M35/04

摘要： A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.

摘要翻译： 高通量流量系统包括井阵列和位于每个井内的单独机械末端。每个机械末端分别致动以赋予剪切应力模式。单独的套筒可以与每个尖端相关联，以保持尖端与尖端相应的井的底板之间的预定距离，每个尖端可在其对应的套筒内旋转。或者，单独的柱可以与每个末端相关联，以保持尖端与尖端相应的井的底部之间的预定距离，其中每个尖端可围绕其相应的柱转动。

2.

发明申请
High-Throughput Biological Screening 有权
标题翻译：高通量生物筛选

公开(公告)号：US20100323916A1

公开(公告)日：2010-12-23

申请号：US12687717

申请日：2010-01-14

申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.

发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.

IPC分类号： C40B30/06 , C40B60/12

CPC分类号： C12M23/12 , C12M35/04

摘要： In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.

摘要翻译： 在一个实施例中，高通量流量系统包括井的阵列和位于每个井内的单独的机械末端。每个机械末端分别致动以赋予剪切应力模式。

3.

发明授权
Method of fabricating microfluidic structures for biomedical applications 有权
标题翻译：制造生物医学应用微流体结构的方法

公开(公告)号：US08266791B2

公开(公告)日：2012-09-18

申请号：US12234215

申请日：2008-09-19

申请人： Jeffrey T. Borenstein , Eli J. Weinberg , James Ching-Ming Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao

发明人： Jeffrey T. Borenstein , Eli J. Weinberg , James Ching-Ming Hsiao , Ahmad S. Khalil , Malinda M. Tupper , Guillermo Garcia-Cardena , Peter Mack , Sarah L. Tao

IPC分类号： H05K3/36 , H05K3/10 , H05K3/02 , B21D53/76 , B23P17/00

CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0861 , B01L2300/12 , B29C33/3857 , B29C59/02 , B29K2025/06 , B29L2031/753 , B33Y80/00 , B81B2201/058 , B81B2203/0338 , B81B2203/0376 , B81C1/00119 , B81C99/0085 , Y10T29/49126 , Y10T29/49155 , Y10T29/49156 , Y10T29/49401 , Y10T156/1039 , Y10T428/139

摘要： Methods of fabricating microfluidic structures featuring substantially circular channels are provided. The methods involve (a) providing a patterned wafer comprising at least one exposed electrically conductive region and at least one exposed electrically insulating region; (b) electroplating an inverse channel portion with substantially semicircular cross section onto the wafer, thereby forming a first master mold; (c) employing the first master mold so as to emboss a channel portion in a first polymer sheet; and (d) aligning and bonding the first polymer sheet with a second polymer sheet having a corresponding channel portion such as to define a first channel with substantially circular cross section between the polymer sheets.

摘要翻译： 提供了制造具有基本圆形通道的微流体结构的方法。所述方法包括（a）提供包括至少一个暴露的导电区域和至少一个暴露的电绝缘区域的图案化晶片; （b）将具有基本上半圆形横截面的反向通道部分电镀到晶片上，从而形成第一主模具; （c）使用所述第一主模具以压缩第一聚合物片材中的通道部分; 和（d）将第一聚合物片材与具有对应的通道部分的第二聚合物片材对准和接合，以限定在聚合物片材之间具有基本圆形横截面的第一通道。