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公开(公告)号：US07417127B2
公开(公告)日：2008-08-26
申请号：US11136538
申请日：2005-05-25
申请人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
发明人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
IPC分类号： C12P21/08
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
摘要翻译： 本发明属于肿瘤学领域。 本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。 本发明还提供编码所述抗体蛋白质的核酸分子。 本发明还涉及生产所述抗体蛋白质的方法。 本发明还提供包含所述抗体蛋白质的药物组合物。 本发明还涉及在制备用于治疗癌症的药物中的用途。
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公开(公告)号：US06972324B2
公开(公告)日：2005-12-06
申请号：US10147849
申请日：2002-05-20
申请人： Günther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
发明人： Günther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
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公开(公告)号：US20050214212A1
公开(公告)日：2005-09-29
申请号：US11136538
申请日：2005-05-25
申请人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John Miglietta , Augustinus Antonius Van Dongen
发明人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John Miglietta , Augustinus Antonius Van Dongen
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
摘要翻译： 本发明属于肿瘤学领域。 本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。 本发明还提供编码所述抗体蛋白质的核酸分子。 本发明还涉及生产所述抗体蛋白质的方法。 本发明还提供包含所述抗体蛋白质的药物组合物。 本发明还涉及在制备用于治疗癌症的药物中的用途。
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公开(公告)号：US07361347B2
公开(公告)日：2008-04-22
申请号：US11173969
申请日：2005-07-01
IPC分类号： A61K39/395
CPC分类号： A61K47/6849 , A61K47/6803
摘要： The invention relates to novel conjugates of CD44 antibodies with cytotoxic compounds, pharmaceutical compositions comprising such compounds, and their use in tumor therapy.
摘要翻译： 本发明涉及CD44抗体与细胞毒性化合物的新型缀合物，包含这些化合物的药物组合物及其在肿瘤治疗中的用途。
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公开(公告)号：US20050271672A1
公开(公告)日：2005-12-08
申请号：US11173969
申请日：2005-07-01
IPC分类号： A61K47/48 , A61K39/395 , C07K16/46
CPC分类号： A61K47/6849 , A61K47/6803
摘要： The invention relates to novel conjugates of CD44 antibodies with cytotoxic compounds, pharmaceutical compositions comprising such compounds, and their use in tumor therapy.
摘要翻译： 本发明涉及CD44抗体与细胞毒性化合物的新型缀合物，包含这些化合物的药物组合物及其在肿瘤治疗中的用途。
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公开(公告)号：US5916561A
公开(公告)日：1999-06-29
申请号：US750359
申请日：1997-02-12
申请人： Gunther R. Adolf , Erik Patzelt
发明人： Gunther R. Adolf , Erik Patzelt
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K49/00 , A61K51/00 , A61P35/00 , C07K14/705 , C07K16/28 , C07K16/30 , C07K16/42 , C12N5/10 , C12N5/18 , C12N5/20 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/574 , G01N33/577 , C12N5/12
CPC分类号： C07K14/70585 , C07K16/2884 , A61K38/00 , C07K2317/34 , C07K2319/00
摘要： The invention concerns an antibody active against an epitope coded by the exon v6 variant of the CD44 gene. The antibody concerned has characteristics superior to those of prior art antibodies and is suitable for use in therapy and diagnosis.
摘要翻译： PCT No.PCT / EP95 / 02126 Sec。 371日期1997年2月12日 102（e）日期1997年2月12日PCT提交1995年6月2日PCT公布。 公开号WO95 / 33771 日期1995年12月14日本发明涉及针对由CD44基因的外显子v6变体编码的表位活性的抗体。 所述抗体具有优于现有技术抗体的特征，适用于治疗和诊断。
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