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    Antiphlogistic pharmaceutical compositions containing a phenylethanolamine and methods of use
    1.
    发明授权
    Antiphlogistic pharmaceutical compositions containing a phenylethanolamine and methods of use 失效
    含有苯乙醇胺的消炎药物组合物及其使用方法

    公开(公告)号：US4244967A

    公开(公告)日：1981-01-13

    申请号：US72553

    申请日：1979-09-04

    申请人： Gunther Engelhardt ,  Johannes Keck ,  Gerd Kruger ,  Klaus Noll ,  Helmut Pieper ,  Rainer Zimmermann

    发明人： Gunther Engelhardt ,  Johannes Keck ,  Gerd Kruger ,  Klaus Noll ,  Helmut Pieper ,  Rainer Zimmermann

    IPC分类号： A61K31/135 ,  A61K31/17 ,  A61K31/275 ,  A61K31/325 ,  A61P29/00 ,  A61P43/00 ,  A61K31/27

    CPC分类号： A61K31/135 ,  A61K31/17 ,  A61K31/275 ,  A61K31/325

    摘要： The method of using compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, cyano, trifluoromethyl, nitro or alkyl of 1 to 4 carbon atoms,R.sub.3 is cycloalkyl or alkyl, each of 3 to 5 carbon atoms, andR.sub.4 is hydrogen or --CO--R.sub.5, whereR.sub.5 is alkoxy of 1 to 5 carbon atoms, alkenyloxy of 2 to 5 carbon atoms, aryloxy of 6 to 10 carbon atoms, aralkoxy of 7 to 11 carbon atoms, or amino which may be mono- or di-substituted by alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, aryl of 6 to 10 carbon atoms and/or aralkyl of 7 to 11 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof as antirheumatics and antiphlogistics.

    摘要翻译： 使用下式化合物的方法其中R1是氢，氟，氯，溴，碘或氰基，R2是氟，氰基，三氟甲基，硝基或1-4个碳原子的烷基，R3是环烷基或烷基， 3〜5个碳原子，R4为氢或-CO-R5，R5为1〜5个碳原子的烷氧基，2〜5个碳原子的烯氧基，6〜10个碳原子的芳氧基，7〜11个芳氧基 碳原子或可以被1至5个碳原子的烷基，2至5个碳原子的烯基，6至10个碳原子的芳基和/或7至11个碳原子的芳烷基单取代或二取代的氨基，以及 无毒，药理学上可接受的酸加成盐作为抗风湿剂和消炎药。

    1-(4-Acylamino-phenyl)-2-amino-ethanols and salts thereof
    2.
    发明授权
    1-(4-Acylamino-phenyl)-2-amino-ethanols and salts thereof 失效
    1-（4-酰基氨基 - 苯基）-2-氨基 - 乙醇及其盐

    公开(公告)号：US4214001A

    公开(公告)日：1980-07-22

    申请号：US883814

    申请日：1978-03-06

    申请人： Gunther Engelhardt ,  Johannes Keck ,  Kruger ,  Klaus Noll ,  Helmut Pieper

    发明人： Gunther Engelhardt ,  Johannes Keck ,  Kruger ,  Klaus Noll ,  Helmut Pieper

    IPC分类号： A61K31/17 ,  A61K31/167 ,  A61K31/27 ,  A61P25/04 ,  A61P25/08 ,  C07C67/00 ,  C07C215/52 ,  C07C239/00 ,  C07C269/00 ,  C07C271/28 ,  C07C271/58 ,  C07C275/28 ,  C07C275/40 ,  A61K31/275 ,  C07C121/80 ,  C07C125/06

    CPC分类号： C07C275/40

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or cyano;R.sub.2 is fluorine, cyano, trifluoromethyl, nitro or alkyl of 1 to 4 carbon atoms;R.sub.3 is alkoxy of 1 to 5 carbon atoms, alkenyloxy of 2 to 5 carbon atoms, aryloxy of 6 to 10 carbon atoms, aralkoxy of 7 to 11 carbon atoms, or --NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 are each hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, aryl of 6 to 10 carbon atoms or aralkyl of 7 to 11 carbon atoms; andR.sub.4 is cycloalkyl of 3 to 5 carbon atoms or alkyl of 3 to 5 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds as well as the salts are useful as analgesics, uterospasmolytics and antiasthmatics.

    摘要翻译： 其中R1是氢，卤素或氰基的式“IMAGE”的化合物; R2是氟，氰基，三氟甲基，硝基或1-4个碳原子的烷基; R3为1〜5个碳原子的烷氧基，2〜5个碳原子的烯氧基，6〜10个碳原子的芳氧基，7〜11个碳原子的芳烷氧基或-NR5R6，其中R5和R6分别为氢， 2至5个碳原子的烯基，6至10个碳原子的芳基或7至11个碳原子的芳烷基; R4为3〜5个碳原子的环烷基或3〜5个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。 化合物以及盐可用作镇痛药，子宫内膜溶解药和止喘药。

    Esters and amides containing the 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl moiety
    3.
    发明授权
    Esters and amides containing the 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl moiety 失效
    含有1-（4-氯苯甲酰基）-5-甲氧基-2-甲基-1H-吲哚-3-乙酰基部分的酯和酰胺

    公开(公告)号：US4362738A

    公开(公告)日：1982-12-07

    申请号：US158587

    申请日：1980-06-11

    申请人： Johannes Keck ,  Gerd Kruger ,  Helmut Pieper ,  Klaus Noll ,  Gunther Engelhardt ,  Norbert Promberger ,  Rainer Zimmermann

    发明人： Johannes Keck ,  Gerd Kruger ,  Helmut Pieper ,  Klaus Noll ,  Gunther Engelhardt ,  Norbert Promberger ,  Rainer Zimmermann

    IPC分类号： C07D209/08 ,  A61K31/495 ,  A61P29/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/16 ,  C07C227/18 ,  C07C229/54 ,  C07C237/32 ,  C07C237/38 ,  C07C313/00 ,  C07C323/12 ,  C07C323/65 ,  C07D209/28 ,  C07D213/74 ,  C07D295/088 ,  C07D295/155 ,  C07D401/12 ,  C07H13/08 ,  C07D279/18 ,  A61K27/00

    CPC分类号： C07D213/74 ,  C07D209/28 ,  C07D295/088 ,  C07D295/155

    摘要： Compounds of the formula ##STR1## wherein each X, which may be identical or different from the other X, is oxygen or imino;R.sub.1 is hydrogen, fluorine, chlorine or bromine;R.sub.2 and R.sub.3, which may be identical or different from each other, are each hydrogen; unsubstituted or mono-substituted alkyl of 1 to 6 carbon atoms, where the substituent is phenyl or dialkylamino with 1 to 3 carbon atoms in each alkyl moiety; pyridyl; or cycloalkyl of 5 to 7 carbon atoms;R.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, are pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-aryl-piperazino or N-(alkyl of 1 to 3 carbon atoms)-piperazino;A is cycloalkylene of 5 to 7 carbon atoms; unsubstituted or substituted alkylene of 2 to 10 carbon atoms, where the substituents are one to two alkyls of 1 to 3 carbon atoms each, one to two carbalkoxys of 2 to 4 carbon atoms each, one to two phenyls, one to four hydroxyls, one halomethyl, one hydroxymethyl, one alkanoyloxy of 1 to 18 carbon atoms, one alkanoyloxymethyl of 1 to 18 carbon atoms in the alkanoyl moiety or one ##STR2## where R.sub.1, R.sub.2 and R.sub.3 have the meanings previously defined; or alkylene of 2 to 10 carbon atoms interrupted by oxygen, sulfur, sulfoxide, sulfonyl, phenyl, cyclohexyl, pyridyl, piperazino or unsubstituted or substituted imino, where the substituent on the imino group is alkyl of 1 to 6 carbon atoms, phenyl or phenylalkyl of 1 to 3 carbon atoms in the alkyl moiety;B is the acyl residue of an antiphlogistic carboxylic acid;and their non-toxic, pharmacologically acceptable acid addition salts. The compounds as well as their salts are useful as anti-inflammatories.

    摘要翻译： 其中每个X可以相同或不同于另一个X的式“IMAGE”的化合物是氧或亚氨基; R1是氢，氟，氯或溴; R2和R3可以相同或不同，分别为氢; 未取代或单取代的1至6个碳原子的烷基，其中取代基为苯基或每个烷基部分具有1至3个碳原子的二烷基氨基; 吡啶基 或5至7个碳原子的环烷基; 吡咯烷基，哌啶子基，六亚甲基亚氨基，吗啉代，N-芳基 - 哌嗪子基或N-（1至3个碳原子的烷基） - 哌嗪基; R 2和R 3彼此连接并连接的氮原子。 A是5至7个碳原子的亚环烷基; 2至10个碳原子的未取代或取代的亚烷基，其中取代基为1至2个碳原子数为1至2个的烷基，每个为2至4个碳原子的1至2个碳烷氧基，1至2个苯基，1至4个羟基，1至2个 卤代甲基，一个羟甲基，一个1至18个碳原子的烷酰氧基，一个在烷酰基部分中具有1至18个碳原子的烷酰氧基甲基或一个，其中R1，R2和R3具有以前定义的含义; 或由氧，硫，亚砜，磺酰基，苯基，环己基，吡啶基，哌嗪子基或未取代或取代的亚氨基所取代的2至10个碳原子的亚烷基，其中亚氨基上的取代基是1至6个碳原子的烷基，苯基或苯基烷基 在烷基部分中具有1至3个碳原子; B是消炎性羧酸的酰基残基; 及其无毒，药理学上可接受的酸加成盐。 化合物及其盐可用作抗炎剂。

    Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts
    4.
    发明授权
    Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts 失效
    支气管解痉剂1-（对氨基 - 苯基）-2-氨基 - 乙醇 - （1）和盐

    公开(公告)号：US4119710A

    公开(公告)日：1978-10-10

    申请号：US754981

    申请日：1976-12-28

    申请人： Gunther Engelhardt ,  Johannes Keck ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Helmut Pieper

    发明人： Gunther Engelhardt ,  Johannes Keck ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Helmut Pieper

    IPC分类号： C07D263/04 ,  C07D317/58 ,  A61K31/04 ,  A61K31/135 ,  A61K31/275 ,  A61K31/36

    CPC分类号： C07D263/04 ,  C07D317/58

    摘要： Racemic and optically active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, trifluoromethyl, nitro or cyano, andR.sub.3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as .beta..sub.2 -receptor mimetics and .beta..sub.1 -receptor blockers.

    摘要翻译： 其中R 1为氢，氟，氯，溴，碘或氰基的外消旋和旋光活性化合物，R 2为氟，三氟甲基，硝基或氰基，R 3为3至5个碳原子的烷基，羟基（烷基 3至5个碳原子的环烷基，3至5个碳原子的环烷基，1-（3,4-亚甲二氧基 - 苯基）-2-丙基或1-（对羟基 - 苯基）-2-丙基，和非毒性 其药理学可接受的酸添加剂; 这些化合物作为其作为骨质疏松症，骨质疏松症，骨质疏松症和骨质疏松症的抗生素有用的化合物，特别适用于β2受体的MIME和β受体阻断剂。

    Printer station with output discharging device for individual sheets
    6.
    发明授权
    Printer station with output discharging device for individual sheets 失效
    带单张纸的出纸装置的打印机

    公开(公告)号：US5061098A

    公开(公告)日：1991-10-29

    申请号：US384736

    申请日：1989-07-21

    申请人： Gunther Engelhardt ,  Gerhard Lohrmann ,  Helmut Riesenegger

    发明人： Gunther Engelhardt ,  Gerhard Lohrmann ,  Helmut Riesenegger

    IPC分类号： B41J13/10

    CPC分类号： B41J13/106

    摘要： A printer station (1) with output discharging device (3) for individual sheets (6) is in particular used for laser page printers. An outwardly directed output discharging device (3) follows to output roller pairs (5), as seen in transport direction (7) of the printed individual sheets (6). In order to dispose the output discharging device (3) in a space-saving fashion, and in order to create the possibility for the operator to adjust the output discharging device (3) to the local special situation, the output discharging device (3) is tiltably supported at the printer frame (4) of the printer station (1), where the output discharging device (3) is furnished with drivable friction roller pairs (13), disposed behind the output roller pairs (5), as seen in transport direction (7). The shafts (14, 15) of the friction roller pairs (13) are in each case rotatably supported at the side walls (8,9) of the tiltable output discharging device (3).

    摘要翻译： 具有用于单张纸（6）的输出排出装置（3）的打印机站（1）特别用于激光打印机。 如印刷的单张纸（6）的输送方向（7）所见，输出辊对（5）的向外指示的输出排出装置（3）。 为了以节省空间的方式配置输出排出装置（3），为了使操作者将输出排出装置（3）调整到本地特殊情况的可能性，输出排出装置（3） 被可倾斜地支撑在打印机站（1）的打印机框架（4）处，其中输出排放装置（3）配备有设置在输出辊对（5）后面的可驱动的摩擦辊对（13），如 运输方向（7）。 摩擦辊对（13）的轴（14,15）各自可旋转地支撑在可倾斜输出排放装置（3）的侧壁（8,9）处。

    2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and salts thereof
    7.
    发明授权
    2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and salts thereof 失效
    2,5-二氢-1,2-噻嗪（5,6-b）吲哚-3-甲酰胺-1,1-二氧化物及其盐

    公开(公告)号：US4137313A

    公开(公告)日：1979-01-30

    申请号：US872889

    申请日：1978-01-27

    申请人： Gunter Trummlitz ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    发明人： Gunter Trummlitz ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    IPC分类号： A61K31/54 ,  A61P7/02 ,  A61P29/00 ,  C07D209/42 ,  C07D513/04 ,  C07D513/14 ,  A61K31/38

    CPC分类号： C07D513/04 ,  C07D209/42 ,  C07D513/14 ,  Y10S514/822

    摘要： Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl or ethyl;Y is hydrogen, fluorine, chlorine, bromine, methoxy, methyl, ethyl or trifluoromethyl; andAr is 2-thiazolyl which may have one or two methyl or ethyl substituents attached thereto; 5,6-dihydro-4H-cyclopentathiazol-2-yl; 4,5,6,7-tetrahydro-2-benzothiazolyl; 2-benzothiazolyl; 3-isothiazolyl which may have a methyl substituent attached thereto; 2-pyridyl which may have a methyl or hydroxyl substituent attached thereto; 3-pyridyl; 4-pyridyl; 4-pyrimidinyl; pyrazinyl; 2-benzimidazolyl; 2-oxazolyl which may have a methyl substituent attached thereto; 2-benzoxazolyl; or phenyl which may have a fluoro, chloro, bromo, methyl, ethyl, trifluoromethyl or methoxy substituent attached thereto; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antiphlogistics and blood platelet aggregation inhibitors.

    摘要翻译： 式中的化合物，其中R1是氢，甲基或乙基; R2是甲基或乙基; Y是氢，氟，氯，溴，甲氧基，甲基，乙基或三氟甲基; 并且Ar是可以具有一个或两个连接到其上的甲基或乙基取代基的2-噻唑基; 5,6-二氢-4H-环戊基噻唑-2-基; 4,5,6,7-四氢-2-苯并噻唑基; 2-苯并噻唑基 可具有与其连接的甲基取代基的3-异噻唑基; 可以具有连接到其上的甲基或羟基取代基的2-吡啶基; 3-吡啶基; 4-吡啶基; 4-嘧啶基; 吡嗪基 2-苯并咪唑基; 可具有与其连接的甲基取代基的2-恶唑基; 2-苯并恶唑基; 或可具有与其连接的氟，氯，溴，甲基，乙基，三氟甲基或甲氧基取代基的苯基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。 化合物及其盐可用作消炎剂和血小板聚集抑制剂。