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    2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and salts thereof
    4.
    发明授权
    2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and salts thereof 失效
    2,5-二氢-1,2-噻嗪（5,6-b）吲哚-3-甲酰胺-1,1-二氧化物及其盐

    公开(公告)号：US4137313A

    公开(公告)日：1979-01-30

    申请号：US872889

    申请日：1978-01-27

    申请人： Gunter Trummlitz ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    发明人： Gunter Trummlitz ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    IPC分类号： A61K31/54 ,  A61P7/02 ,  A61P29/00 ,  C07D209/42 ,  C07D513/04 ,  C07D513/14 ,  A61K31/38

    CPC分类号： C07D513/04 ,  C07D209/42 ,  C07D513/14 ,  Y10S514/822

    摘要： Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl or ethyl;Y is hydrogen, fluorine, chlorine, bromine, methoxy, methyl, ethyl or trifluoromethyl; andAr is 2-thiazolyl which may have one or two methyl or ethyl substituents attached thereto; 5,6-dihydro-4H-cyclopentathiazol-2-yl; 4,5,6,7-tetrahydro-2-benzothiazolyl; 2-benzothiazolyl; 3-isothiazolyl which may have a methyl substituent attached thereto; 2-pyridyl which may have a methyl or hydroxyl substituent attached thereto; 3-pyridyl; 4-pyridyl; 4-pyrimidinyl; pyrazinyl; 2-benzimidazolyl; 2-oxazolyl which may have a methyl substituent attached thereto; 2-benzoxazolyl; or phenyl which may have a fluoro, chloro, bromo, methyl, ethyl, trifluoromethyl or methoxy substituent attached thereto; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antiphlogistics and blood platelet aggregation inhibitors.

    摘要翻译： 式中的化合物，其中R1是氢，甲基或乙基; R2是甲基或乙基; Y是氢，氟，氯，溴，甲氧基，甲基，乙基或三氟甲基; 并且Ar是可以具有一个或两个连接到其上的甲基或乙基取代基的2-噻唑基; 5,6-二氢-4H-环戊基噻唑-2-基; 4,5,6,7-四氢-2-苯并噻唑基; 2-苯并噻唑基 可具有与其连接的甲基取代基的3-异噻唑基; 可以具有连接到其上的甲基或羟基取代基的2-吡啶基; 3-吡啶基; 4-吡啶基; 4-嘧啶基; 吡嗪基 2-苯并咪唑基; 可具有与其连接的甲基取代基的2-恶唑基; 2-苯并恶唑基; 或可具有与其连接的氟，氯，溴，甲基，乙基，三氟甲基或甲氧基取代基的苯基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。 化合物及其盐可用作消炎剂和血小板聚集抑制剂。

    4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof
    7.
    发明授权
    4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
    4-羟基-2H-萘并（{2,1-e {9-1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐

    公开(公告)号：US3992535A

    公开(公告)日：1976-11-16

    申请号：US626623

    申请日：1975-10-29

    申请人： Gunter Trummlitz ,  Helmut Teufel ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    发明人： Gunter Trummlitz ,  Helmut Teufel ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    IPC分类号： C07D275/06 ,  C07D279/02 ,  C07D417/12 ,  C07D513/04 ,  A61K31/54

    CPC分类号： C07D275/06 ,  C07D279/02

    摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or ethyl, andAr is phenyl, 3-chlorophenyl, 3-bromophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, 2-pyridyl, 4-methyl-2-pyridyl, 6-methyl-2-pyridyl, 3-hydroxy-2-pyridyl, 3-pyridyl, 4-pyridyl, 6-chloro-3-pyridazinyl, 2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-chloro-4-pyrimidinyl, 2-thiazolyl, 4-methyl-2-thiazolyl, 4-ethyl-2-thiazolyl, 5-methyl-2-thiazolyl, 5-ethyl-2-thiazolyl, 4,5-dimethyl-2-thiazolyl, 4-ethyl-5-methyl-2-thiazolyl, 5-ethyl-4-methyl-2-thiazolyl, 2-benzothiazolyl, 4,5,6,7-tetrahydro-2-benzothiazolyl, 5,6-dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl, 3-methyl-5-isothiazolyl, 1,3,4-thiadiazolyl, 5-methyl-1,3,4-thiadiazol-2-yl or 5-methyl-3-isoxazolyl,And non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds as well as their salts are useful as inhibitors of platelet adhesion and aggregation.

    摘要翻译： 式WHERE R1的化合物是氢，甲基或乙基，Ar是苯基，3-氯苯基，3-溴苯基，2-氟苯基，3-氟苯基，4-氟苯基，3-甲苯基，2-甲氧基苯基，3-甲氧基苯基， 2-吡啶基，4-甲基-2-吡啶基，6-甲基-2-吡啶基，3-羟基-2-吡啶基，3-吡啶基，4-吡啶基，6-氯-3-哒嗪基，2-吡嗪基，6-吡啶基， 4-氯-2-吡嗪基，6-氯-4-嘧啶基，2-噻唑基，4-甲基-2-噻唑基，4-乙基-2-噻唑基，5-甲基-2-噻唑基，5-乙基-2-噻唑基， 4,5-二甲基-2-噻唑基，4-乙基-5-甲基-2-噻唑基，5-乙基-4-甲基-2-噻唑基，2-苯并噻唑基，4,5,6,7-四氢-2- 苯并噻唑基，5,6-二氢-7H-噻喃并[4,3-d]噻唑-2-基，3-甲基-5-异噻唑基，1,3,4-噻二唑基，5-甲基-1,3,4-噻二唑基， 噻二唑-2-基或5-甲基-3-异恶唑基，以及与无机或有机碱形成的非毒性，药理学上可接受的盐; 化合物作为它们的盐作为板材粘合和聚集的抑制剂有用。