公开(公告)号：US20110018053A1

公开(公告)日：2011-01-27

申请号：US12746401

申请日：2007-12-07

申请人： Guo Qiang Patrick Lo ,  Jia Fu ,  Mingbin Yu ,  Navab Singh

发明人： Guo Qiang Patrick Lo ,  Jia Fu ,  Mingbin Yu ,  Navab Singh

IPC分类号： H01L29/792 ,  H01L21/28

CPC分类号： H01L29/0665 ,  B82Y10/00 ,  G11C16/10 ,  G11C2216/06 ,  H01L29/0673 ,  H01L29/40117 ,  H01L29/42348 ,  H01L29/66833 ,  H01L29/775 ,  H01L29/792

摘要： A memory cell is provided. The memory cell comprises a first wire shaped channel structure; and a charge trapping structure surrounding the perimeter surface of the first wire shaped channel structure, the charge trapping structure comprising two charge trapping partial to structures, wherein each charge trapping partial structure is formed of a different material capable of storing electrical charges. Methods of manufacturing the memory cell are also provided.

摘要翻译： 提供存储单元。 存储单元包括第一线形通道结构; 以及围绕第一线形沟道结构的周边表面的电荷捕获结构，电荷捕获结构包括两个电荷俘获部分结构，其中每个电荷捕获部分结构由能够存储电荷的不同材料形成。 还提供了制造存储单元的方法。

公开(公告)号：US08822716B2

公开(公告)日：2014-09-02

申请号：US13148578

申请日：2010-02-08

申请人： He Tang ,  Wenqiu Yuan ,  Jia Fu

发明人： He Tang ,  Wenqiu Yuan ,  Jia Fu

IPC分类号： C07C69/716 ,  C07C69/67 ,  C07C59/115 ,  C07C51/08 ,  C07C253/00 ,  C07C69/675 ,  C07C67/08 ,  C07C67/313 ,  C07C319/14

CPC分类号： C07C69/675 ,  C07C51/08 ,  C07C59/115 ,  C07C67/08 ,  C07C67/313 ,  C07C253/00 ,  C07C319/14 ,  C07C2601/02 ,  C07C69/716 ,  C07C323/59 ,  C07C255/16

摘要： Disclosed is a method for preparing 7-halo-2-oxoheptylate, an intermediate of cilastatin. The main steps are as follows: A. Addition reaction, in which 6-halo-hexanal is reacted with a cyanide to obtain 7-halo-α-hydroxyl-heptonitrile; B. Hydrolysis reaction, in which 7-halo-α-hydroxyl-heptonitrile is converted to 7-halo-α-hydroxyl-heptylic acid; C. Esterification reaction, in which 7-halo-α-hydroxyl-heptylic acid is converted to 7-halo-α-hydroxyl-heptylate; and D. Oxidation reaction, in which 7-halo-α-hydroxyl-heptylate is converted to 7-halo-2-oxoheptylate. 7-halo-α-hydroxyl-heptylic acid or ester thereof, which is a new intermediate for synthesizing 7-halo-2-oxoheptylate or cilastatin, and a method for synthesizing cilastatin are also disclosed. The methods of the invention are suitable for commercial production because of their simple process and mild reaction condition.

摘要翻译： 公开了一种制备西洛司汀中间体7-卤-2-氧代庚酸盐的方法。 主要步骤如下：A.加入反应，其中6-卤代 - 己醛与氰化物反应得到7-卤代-α-羟基 - 庚腈; B.水解反应，其中7-卤代-α-羟基 - 庚腈转化为7-卤代-α-羟基 - 庚基酸; C.酯化反应，其中7-卤代-α-羟基 - 庚酸转化为7-卤代-α-羟基 - 庚基化物; 和D.氧化反应，其中7-卤代-α-羟基 - 庚酸酯转化为7-卤代-2-氧代庚酸盐。 还公开了作为合成7-卤-2-氧代庚酸盐或西司他丁的新中间体的7-卤-α-羟基 - 庚酸或其酯，以及合成西司他丁的方法。 本发明的方法由于工艺简单，反应条件温和，适用于商业生产。

公开(公告)号：US20110319653A1

公开(公告)日：2011-12-29

申请号：US13148578

申请日：2010-02-08

申请人： He Tang ,  Wenqiu Yuan ,  Jia Fu

发明人： He Tang ,  Wenqiu Yuan ,  Jia Fu

IPC分类号： C07C319/14 ,  C07C69/675 ,  C07C67/22

CPC分类号： C07C69/675 ,  C07C51/08 ,  C07C59/115 ,  C07C67/08 ,  C07C67/313 ,  C07C253/00 ,  C07C319/14 ,  C07C2601/02 ,  C07C69/716 ,  C07C323/59 ,  C07C255/16

摘要： Disclosed is a method for preparing 7-halo-2-oxoheptylate, an intermediate of cilastatin. The main steps are as follows: A. Addition reaction, in which 6-halo-hexanal is reacted with a cyanide to obtain 7-halo-α-hydroxyl-heptonitrile; B. Hydrolysis reaction, in which 7-halo-α-hydroxyl-heptonitrile is converted to 7-halo-α-hydroxyl-heptylic acid; C. Esterification reaction, in which 7-halo-α-hydroxyl-heptylic acid is converted to 7-halo-α-hydroxyl-heptylate; and D. Oxidation reaction, in which 7-halo-α-hydroxyl-heptylate is converted to 7-halo-2-oxoheptylate. 7-halo-α-hydroxyl-heptylic acid or ester thereof, which is a new intermediate for synthesizing 7-halo-2-oxoheptylate or cilastatin, and a method for synthesizing cilastatin are also disclosed. The methods of the invention are suitable for commercial production because of their simple process and mild reaction condition.

摘要翻译： 公开了一种制备西洛司汀中间体7-卤-2-氧代庚酸盐的方法。 主要步骤如下：A.加入反应，其中6-卤代 - 己醛与氰化物反应得到7-卤代-α-羟基 - 庚腈; B.水解反应，其中7-卤代-α-羟基 - 庚腈转化为7-卤代-α-羟基 - 庚基酸; C.酯化反应，其中7-卤代-α-羟基 - 庚酸转化为7-卤代-α-羟基 - 庚基化物; 和D.氧化反应，其中7-卤代-α-羟基 - 庚酸酯转化为7-卤代-2-氧代庚酸盐。 还公开了作为合成7-卤-2-氧代庚酸盐或西司他丁的新中间体的7-卤-α-羟基 - 庚酸或其酯，以及合成西司他丁的方法。 本发明的方法由于工艺简单，反应条件温和，适用于商业生产。