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13 条记录 (耗时 0.024 秒)

    Methods for screening drugs to predict tardive dyskinesia
    1.
    发明授权
    Methods for screening drugs to predict tardive dyskinesia 失效
    筛选药物预测迟发性运动障碍的方法

    公开(公告)号：US06316269B1

    公开(公告)日：2001-11-13

    申请号：US09166594

    申请日：1998-10-06

    申请人： Guochuan Tsai ,  Xudong Huang ,  Ashley I. Bush

    发明人： Guochuan Tsai ,  Xudong Huang ,  Ashley I. Bush

    IPC分类号： G01N3300

    CPC分类号： G01N33/84 ,  G01N33/94 ,  G01N2500/00 ,  Y10T436/20 ,  Y10T436/203332 ,  Y10T436/206664

    摘要： The present invention provides screening methods for identifying compounds which induce tardive dyskinesia (TD) when administered to an animal. In particular, the methods involve assaying for intermediates and end products of reactions associated with candidate compound mediated reduction of reducible substrates. Also provided are high-throughput screening methods for determining whether compounds induce TD when administered to an animal. Further, provided are methods for treating psychoses comprising testing antipsychotic drugs to identify those which will not induce TD when administered to an animal and administering one or more such drugs to a patient in need thereof.

    摘要翻译： 本发明提供了当给予动物时鉴定诱导迟发性运动障碍（TD）的化合物的筛选方法。 特别地，该方法包括测定与候选化合物介导的可还原底物的还原相关的反应的中间体和终产物。 还提供了用于确定化合物在给予动物时是否诱导TD的高通量筛选方法。 此外，提供了治疗精神病的方法，包括测试抗精神病药物以鉴定当施用于动物时不会诱导TD并且向有需要的患者施用一种或多种此类药物的那些。

    Amyloid-binding, metal-chelating agents
    5.
    发明申请
    Amyloid-binding, metal-chelating agents 审中-公开
    淀粉样结合，金属螯合剂

    公开(公告)号：US20060035946A1

    公开(公告)日：2006-02-16

    申请号：US11096919

    申请日：2005-04-01

    申请人： Xudong Huang ,  Jonathan Kremsky ,  Perry Catchings

    发明人： Xudong Huang ,  Jonathan Kremsky ,  Perry Catchings

    IPC分类号： A61K31/428 ,  C07D417/02

    CPC分类号： C07D277/66 ,  A61K31/425

    摘要： The present invention relates to the diagnosis, prevention, and treatment of pathophysiological conditions associated with amyloid accumulation. Bifunctional therapeutic molecules and contrast imaging agents exhibiting a high affinity for amyloid deposits, and pharmaceutical compositions thereof are described. The invention also provides methods of using these bifunctional molecules, contrast imaging agents, and pharmaceutical compositions for detecting the presence of amyloid deposits using imaging techniques; and for preventing or treating amyloid-related conditions, such as, for example, Alzheimer's disease.

    摘要翻译： 本发明涉及与淀粉样蛋白积累相关的病理生理条件的诊断，预防和治疗。 描述了对淀粉样沉积物表现出高亲和力的双功能治疗分子和造影剂，以及其药物组合物。 本发明还提供了使用成像技术使用这些双功能分子，造影剂和药物组合物来检测淀粉样沉积物的存在的方法; 并用于预防或治疗淀粉样蛋白相关病症，例如阿尔茨海默病。

    Methods of creating patterns on substrates and articles of manufacture resulting therefrom
    6.
    发明授权
    Methods of creating patterns on substrates and articles of manufacture resulting therefrom 失效
    在由此产生的基材和制品上形成图案的方法

    公开(公告)号：US06860956B2

    公开(公告)日：2005-03-01

    申请号：US10444505

    申请日：2003-05-23

    申请人： Lirong Bao ,  Li Tan ,  Xudong Huang ,  Yen Peng Kong ,  Lingjie Jay Guo ,  Stella W. Pang ,  Albert Yee

    发明人： Lirong Bao ,  Li Tan ,  Xudong Huang ,  Yen Peng Kong ,  Lingjie Jay Guo ,  Stella W. Pang ,  Albert Yee

    IPC分类号： B05D3/10 ,  B29C33/00 ,  B44C1/165 ,  B44C3/08 ,  C03C17/30 ,  G03F20060101 ,  G03F7/00 ,  B32B31/20

    CPC分类号： G03F7/0002 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00

    摘要： Methods of creating patterns on substrates are presented, and articles of manufacture resulting therefrom. One method comprises applying a first surface energy modifier to an applicator to form a coating on the applicator; contacting the coating with a receiving member, the receiving member having a topography, the coating only contacting and remaining on at least some protrusions; exposing the first modified receiving member to a second surface energy modifier, thereby forming a second modified receiving member having surface modified recesses; applying a composition comprising a polymeric material to the second modified receiving member, the composition substantially conforming to the topography of the surface modified protrusions and the surface modified recesses; and contacting the composition-coated, surface modified protrusions with a substrate for a time and under conditions sufficient to transfer the polymeric material on protrusions to the substrate. Because the surface energy of the sidewalls is lower than that on the protrusions, polymer dewetting from the sidewalls is promoted, which makes the polymer film discontinuous along the edges of patterns. Therefore, inked polymer patterns from the protrusions of the mold show very smooth edges and smaller dimensions compared to that of the mold.

    摘要翻译： 提出了在基板上产生图案的方法以及由此产生的制品。 一种方法包括将第一表面能量调节剂施加到施用器以在施用器上形成涂层; 使所述涂层与接收构件接触，所述接收构件具有形貌，所述涂层仅接触并保留在至少一些突起上; 将第一改进的接收构件暴露于第二表面能改变器，由此形成具有表面改性凹槽的第二改进的接收构件; 将包含聚合物材料的组合物施加到所述第二改性接收构件，所述组合物基本上符合所述表面改性突起和所述表面改性凹槽的形貌; 并且将组合物涂覆的表面改性突起与衬底接触足以将聚合物材料在突起上转移到衬底上的时间和条件下。 由于侧壁的表面能低于突起上的表面能，因此促进了从侧壁的聚合物去湿，这使得聚合物膜沿着图案的边缘不连续。 因此，与模具相比，来自模具的凸起的上色聚合物图案显示出非常光滑的边缘和更小的尺寸。

    RAPID ADJUSTABLE WRENCH
    8.
    发明申请
    RAPID ADJUSTABLE WRENCH 审中-公开
    快速可调扳手

    公开(公告)号：US20140190318A1

    公开(公告)日：2014-07-10

    申请号：US14237061

    申请日：2012-07-25

    申请人： Xudong Huang

    发明人： Xudong Huang

    IPC分类号： B25B13/14

    CPC分类号： B25B13/14

    摘要： The present invention relates to a rapid adjustable wrench, the wrench is provided with a worm rotation window on the lower side of the fixed wrench head, the support holes are provided on the both sides of the window, the support holes are the elongated aperture holes that enable the pin shift can radially moving up and down, the spring locating holes are provided on the lower side face of the elongated aperture holes respectively, the spring holds up the pin shaft to prompt the engagement of the teeth of the worm with the teeth of the adjustable wrench head; the length of the spring after the depress at least ensure that the length of the radial displacement of the worm teeth does not exceed the height of the adjustable wrench head teeth, the adjustable wrench head teeth have at least one tooth on the top end of the clamping face side, which height higher than that of the subsequent other teeth. The invention has a simple structure, convenient to use, holding the handle of the wrench with hands and pinching the worm with thumb and forefinger simultaneously to pull it down, such that it can quickly adjust the opening size of the clamping face, improving the using efficiency of the adjustable wrench; the settings for the different teeth height of the adjustable wrench head, in the case of the adjustable wrench head does not removed when achieve the adjustment of the opening size of the clamping face, reducing the processing operation to the adjustable wrench, saving the expense.

    摘要翻译： 本发明涉及一种快速调节扳手，扳手在固定扳手头的下侧设有蜗轮旋转窗，支撑孔设置在窗的两侧，支撑孔是细长的孔孔 使得销移动可以径向向上和向下移动，弹簧定位孔分别设置在细长孔眼的下侧面上，弹簧保持销轴，以促使蜗杆的齿与齿啮合 的可调扳手头; 压紧后的弹簧长度至少可确保蜗轮的径向位移长度不超过可调扳手头齿的高度，可调扳手头齿的顶端至少有一个齿 夹紧面侧，其高度高于随后的其他牙齿的高度。 本发明结构简单，使用方便，用手握住扳手手柄，同时用拇指和食指捏住蜗杆将其拉下，使其能够快速调节夹紧面的开口尺寸，改善使用 可调扳手的效率; 可调节扳手头的不同齿高度的设置，在可调扳手头的情况下，当实现夹紧面的开口尺寸的调整时，不会移除，从而将加工操作减少到可调扳手，节省费用。