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公开(公告)号：US20090041723A1
公开(公告)日：2009-02-12
申请号：US11974744
申请日：2007-10-15
申请人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Man Iu Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Rouqiu , C. Richard Wobbe
发明人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Man Iu Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Rouqiu , C. Richard Wobbe
IPC分类号： A61K38/21 , A61K31/454 , C07D401/08 , A61K38/05 , C07D413/12 , C07D417/12 , A61K38/43 , A61P31/12
CPC分类号： C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12
摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.
摘要翻译： 提供了芳基取代的吡唑衍生物，以及其制备方法。 本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。
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2.发明授权公开(公告)号：US07923004B2
公开(公告)日：2011-04-12
申请号：US11974744
申请日：2007-10-15
申请人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Ruoqiu , C. Richard Wobbe , Yixin Liu
发明人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Ruoqiu , C. Richard Wobbe , Yixin Liu
IPC分类号： A61K38/21
CPC分类号： C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12
摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.
摘要翻译： 提供了芳基取代的吡唑衍生物，以及其制备方法。 本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。
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公开(公告)号：US08143276B2
公开(公告)日：2012-03-27
申请号：US11895088
申请日：2007-08-22
申请人： Zhen Yang , Reza Fathi , Qiang Zhu , Hyun-Joon Cho , Yixin Liu , Anthony Sandrasagra , C. Richard Wobbe
发明人： Zhen Yang , Reza Fathi , Qiang Zhu , Hyun-Joon Cho , Yixin Liu , Anthony Sandrasagra , C. Richard Wobbe
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D215/36 , C07D471/04
摘要： The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.
摘要翻译： 本发明涉及4-硫代取代的喹啉和萘啶衍生物及其制备方法。 本发明还涉及通过施用4-硫代取代的喹啉或萘啶衍生物来治疗丙型肝炎病毒感染的方法。
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公开(公告)号：US20090054477A1
公开(公告)日：2009-02-26
申请号：US11895088
申请日：2007-08-22
申请人： Zhen Yang , Reza Fathi , Qiang Zhu , Hyun-Joon Cho , Yixin Liu , Anthony Sandrasagra , C. Richard Wobbe
发明人： Zhen Yang , Reza Fathi , Qiang Zhu , Hyun-Joon Cho , Yixin Liu , Anthony Sandrasagra , C. Richard Wobbe
IPC分类号： A61K31/4375 , A61K31/47 , A61P31/00 , C07D215/00 , C07D471/02
CPC分类号： C07D215/36 , C07D471/04
摘要： The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.
摘要翻译： 本发明涉及4-硫代取代的喹啉和萘啶衍生物及其制备方法。 本发明还涉及通过施用4-硫代取代的喹啉或萘啶衍生物来治疗丙型肝炎病毒感染的方法。
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5.发明授权TFIIB transcription factor from Candida albicans and methods of screening for inhibitors of Candida albicans growth 失效来自白色念珠菌的TFIIB转录因子和筛选白念珠菌生长抑制剂的方法公开(公告)号：US06300067B1
公开(公告)日：2001-10-09
申请号：US09204841
申请日：1998-12-03
IPC分类号： C12Q168
摘要： The invention encompasses a novel transcription factor from Candida albicans, TFIIB, a nucleic acid sequence encoding TFIIB, and methods of screening for inhibitors of Candida albicans growth by targeting TFIIB.
摘要翻译： 本发明包括来自白色念珠菌的新型转录因子，TFIIB，编码TFIIB的核酸序列，以及通过靶向TFIIB筛选白念珠菌生长抑制剂的方法。
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公开(公告)号：US6004779A
公开(公告)日：1999-12-21
申请号：US138024
申请日：1998-08-21
申请人： John D. Bradley , Craig M. Thompson , Jeffrey B. Moore , C. Richard Wobbe , Judith M. Healy , Caroline E. Donnelly
发明人： John D. Bradley , Craig M. Thompson , Jeffrey B. Moore , C. Richard Wobbe , Judith M. Healy , Caroline E. Donnelly
CPC分类号： C07K14/395 , C12N15/81
摘要： The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells.
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公开(公告)号：US06365409B1
公开(公告)日：2002-04-02
申请号：US09404066
申请日：1999-09-23
申请人： John D. Bradley , Craig M. Thompson , Jeffrey B. Moore , C. Richard Wobbe , Judith M. Healy , Caroline E. Donnelly
发明人： John D. Bradley , Craig M. Thompson , Jeffrey B. Moore , C. Richard Wobbe , Judith M. Healy , Caroline E. Donnelly
IPC分类号： C12N1574
CPC分类号： C07K14/395 , C12N15/81
摘要： The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells.
摘要翻译： 本发明提供了包含可在金属离子存在或不存在下通过生长调节表达的基因的新型酵母细胞，以及用于制备这种酵母细胞的方法，以及使用这种酵母细胞确定特定生长基因表达需求的方法 或酵母细胞的活力。
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8.发明授权公开(公告)号：US06329378B1
公开(公告)日：2001-12-11
申请号：US09501758
申请日：2000-02-10
申请人： Xiaodan Mei , Peng Wang , Andrei Caracoti , Pamela Mingo , Vincent Boyd , Robert Murray , Nicholas J. Sisti , Yi Bin Xiang , Shuhao Zhu , C. Richard Wobbe , Daniel Moore
发明人： Xiaodan Mei , Peng Wang , Andrei Caracoti , Pamela Mingo , Vincent Boyd , Robert Murray , Nicholas J. Sisti , Yi Bin Xiang , Shuhao Zhu , C. Richard Wobbe , Daniel Moore
IPC分类号： C07D24112
CPC分类号： C07D213/53 , C07C251/86 , C07C337/08 , C07D241/20 , C07D401/12
摘要： Disclosed are pharmaceutical compositions comprising aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, and methods for using the compositions as antifungal agents. The invention also relates to novel aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, their preparation, to pharmaceutical compositions containing them, and to methods of using them to alleviate fungal infections.
摘要翻译： 公开了包含式I和II的芳基和杂芳基腙，肼和缩氨基硫脲酮衍生物的药物组合物，以及使用该组合物作为抗真菌剂的方法。 本发明还涉及式I和II的新型芳基和杂芳基腙，肼和缩氨基硫脲酮衍生物，其制备方法，含有它们的药物组合物，以及使用它们减轻真菌感染的方法。
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公开(公告)号：US6165998A
公开(公告)日：2000-12-26
申请号：US153202
申请日：1998-09-15
申请人： C. Richard Wobbe , John D. Bradley , Zhe Li
发明人： C. Richard Wobbe , John D. Bradley , Zhe Li
IPC分类号： A61K31/05 , A61K31/165 , A61K31/275 , A61K31/655 , A61K31/69 , C07C39/373 , C07C235/56 , C07C245/08
CPC分类号： A61K31/69 , A61K31/05 , A61K31/165 , A61K31/275 , A61K31/655 , C07C39/373 , C07C235/56 , C07C245/08
摘要： The present invention provides azo and stilbene compounds having the structure: wherein XY is N.dbd.N, CH.dbd.CH, (C.dbd.O)--NH or NH--(C.dbd.O); wherein Z is CR.sub.6 or N; wherein R.sub.1, R.sub.2 and R.sub.5 are independently hydrogen, halogen, NO.sub.2 or CF.sub.3 ; wherein R.sub.3 is hydrogen, halogen, CF.sub.3, aryl or heteroaryl, NO.sub.2 or OCF.sub.3 ; wherein R.sub.4 is hydrogen, halogen, CF.sub.3, aryl or heteroaryl, NO.sub.2 or linear or branched chain alkoxy; wherein R.sub.6 is hydrogen or linear or branched alkyl; wherein R.sub.7 is hydrogen, cyano, hydroxyalkyl, carboxyl, halogen, hydroxyl, formyl, NO.sub.2 or halogen; and wherein R.sub.8 is hydroxyl or substituted or unsubstituted amino; and wherein R.sub.9 and R.sub.10 are independently hydrogen, CN or hydroxyalkyl. Said compounds are useful as antifungal therapeutics, fungicides and fungistats. The present invention also provides methods of inhibiting fungal RNA transcription and treating fungal infections in human and animal subjects and fungal infestations in plants.
摘要翻译： 本发明提供具有以下结构的偶氮和二苯乙烯化合物：其中XY是N = N，CH = CH，（C = O）-NH或NH-（C = O）; 其中Z为CR 6或N; 其中R1，R2和R5独立地是氢，卤素，NO2或CF3; 其中R 3是氢，卤素，CF 3，芳基或杂芳基，NO 2或OCF 3; 其中R 4是氢，卤素，CF 3，芳基或杂芳基，NO 2或直链或支链烷氧基; 其中R6是氢或直链或支链烷基; 其中R 7为氢，氰基，羟基烷基，羧基，卤素，羟基，甲酰基，NO 2或卤素; 并且其中R8是羟基或取代或未取代的氨基; 并且其中R 9和R 10独立地为氢，CN或羟基烷基。 所述化合物可用作抗真菌治疗剂，杀真菌剂和真菌剂。 本发明还提供抑制真菌RNA转录和治疗人和动物受试者的真菌感染和植物中的真菌侵袭的方法。
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10.发明授权
公开(公告)号：US5863762A
公开(公告)日：1999-01-26
申请号：US625377
申请日：1996-04-01
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , C07K14/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/725 , G01N33/15 , C12N15/11 , C12N15/63
摘要： The invention encompasses a novel transcription factor from Candida albicans, TFIIB, a nucleic acid sequence encoding TFIIB, and methods of screening for inhibitors of Candida albicans growth by targeting TFIIB.
摘要翻译： 本发明包括来自白色念珠菌的新型转录因子，TFIIB，编码TFIIB的核酸序列，以及通过靶向TFIIB筛选白念珠菌生长抑制剂的方法。
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