公开(公告)号：US20180185005A1

公开(公告)日：2018-07-05

申请号：US15909661

申请日：2018-03-01

申请人： Gursharan Singh Sandhu ,  Nebojsa Duric ,  Cuiping Li ,  Olivier Roy ,  Erik West

发明人： Gursharan Singh Sandhu ,  Nebojsa Duric ,  Cuiping Li ,  Olivier Roy ,  Erik West

IPC分类号： A61B8/13 ,  A61B8/08

CPC分类号： A61B8/13 ,  A61B8/0825 ,  A61B8/085 ,  A61B8/15 ,  A61B8/406 ,  A61B8/4209 ,  A61B8/4281 ,  A61B8/4483 ,  A61B8/463 ,  A61B8/466 ,  A61B8/483 ,  A61B8/485 ,  A61B8/52 ,  A61B8/5223 ,  G06T11/003 ,  G06T11/40

摘要： This application presents a system and related methods that analyze a volume of tissue using ultrasound waveform tomography imaging. By using frequency-domain waveform tomography techniques and a gradient descent algorithm, the system can reconstruct the sound speed distributions of a volume of tissue, such as breast tissue, of varying densities with different types of lesions. By allowing sound speed to have an imaginary component that characterizes sound attenuation, the system can classify the different types of lesions with a fine granularity.

公开(公告)号：US20130041261A1

公开(公告)日：2013-02-14

申请号：US13566778

申请日：2012-08-03

申请人： Cuiping Li ,  Nebojsa Duric

发明人： Cuiping Li ,  Nebojsa Duric

IPC分类号： A61B8/15

CPC分类号： A61B8/5207 ,  A61B8/0825 ,  A61B8/14 ,  A61B8/15 ,  A61B8/406 ,  A61B8/4477 ,  A61B8/5223

摘要： The method of one embodiment for multi-grid tomographic inversion tissue imaging comprises receiving acoustic waveform data characterizing a volume of tissue, determining and refining models of the distributions of a first and second acoustomechanical parameter within the volume of tissue using a series of grids with progressively finer discretization levels, and generating an image based on at least one of the refined models of the first and second acoustomechanical parameters. The system of one embodiment for multi-grid tomographic inversion tissue imaging comprises ultrasound emitters configured to surround and emit acoustic waveforms toward a volume of tissue, ultrasound receivers configured to surround tissue and receive acoustic waveforms, and a processor configured to determine and refine models of the distributions of a first and second acoustomechanical parameter within a volume of tissue, and generate an image based on at least one of the refined models of the first and second acoustomechanical parameters.

摘要翻译： 用于多层次断层扫描反转组织成像的一个实施例的方法包括接收表征组织体积的声波形数据，使用一系列具有逐渐变化的网格来确定和改进组织体积内第一和第二声学参数分布的模型 更精细的离散化水平，以及基于第一和第二声学参数的精细模型中的至少一个生成图像。 用于多层次断层扫描反转组织成像的一个实施例的系统包括超声发射器，其被配置为围绕组织体积并发出声波形，被配置为围绕组织并接收声波形的超声波接收器，以及被配置为确定和改善 在组织体积内的第一和第二声力参数的分布，并且基于第一和第二声学力学参数的精确模型中的至少一个来生成图像。

公开(公告)号：US20130041260A1

公开(公告)日：2013-02-14

申请号：US13208193

申请日：2011-08-11

申请人： Steven Schmidt ,  Cuiping Li ,  Olivier Roy ,  Ivana Jovanovic

发明人： Steven Schmidt ,  Cuiping Li ,  Olivier Roy ,  Ivana Jovanovic

IPC分类号： A61B8/00

CPC分类号： A61B8/0825 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/483 ,  A61B8/5207

摘要： A method for imaging a volume of tissue in a scan region, including: emitting, from transmitting transducers, acoustic waveforms toward the volume of tissue; detecting, with detecting transducers, a plurality acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating from the detected acoustic signals a plurality of variable attenuation maps, in which each variable attenuation map corresponds to acoustic signals detected by a respective detecting transducer and includes a plurality of variable attenuation coefficients mapped to the scan region; modifying at least a portion of the detected acoustic signals based on one or more variable attenuation maps; and generating a reflection rendering of the volume of tissue based on the modified acoustic signals.

摘要翻译： 一种用于对扫描区域中的组织体积进行成像的方法，包括：从发射换能器向所述组织体积发射声波; 用检测换能器检测从与组织体积相互作用的声波形得到的多个声信号; 从检测到的声学信号中产生多个可变衰减图，其中每个可变衰减映射对应于由相应检测换能器检测到的声信号，并且包括映射到扫描区域的多个可变衰减系数; 基于一个或多个可变衰减图来修改检测到的声信号的至少一部分; 以及基于经修改的声信号产生组织体积的反射呈现。

公开(公告)号：US08663113B2

公开(公告)日：2014-03-04

申请号：US13208193

申请日：2011-08-11

申请人： Steven P Schmidt ,  Cuiping Li ,  Olivier Roy ,  Ivana Jovanovic

发明人： Steven P Schmidt ,  Cuiping Li ,  Olivier Roy ,  Ivana Jovanovic

IPC分类号： A61B8/00

CPC分类号： A61B8/0825 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/483 ,  A61B8/5207

摘要： A method for imaging a volume of tissue in a scan region, including: emitting, from transmitting transducers, acoustic waveforms toward the volume of tissue; detecting, with detecting transducers, a plurality acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating from the detected acoustic signals a plurality of variable attenuation maps, in which each variable attenuation map corresponds to acoustic signals detected by a respective detecting transducer and includes a plurality of variable attenuation coefficients mapped to the scan region; modifying at least a portion of the detected acoustic signals based on one or more variable attenuation maps; and generating a reflection rendering of the volume of tissue based on the modified acoustic signals.

摘要翻译： 一种用于对扫描区域中的组织体积进行成像的方法，包括：从发射换能器向所述组织体积发射声波; 用检测换能器检测从与组织体积相互作用的声波形得到的多个声信号; 从检测到的声学信号中产生多个可变衰减图，其中每个可变衰减映射对应于由相应检测换能器检测到的声信号，并且包括映射到扫描区域的多个可变衰减系数; 基于一个或多个可变衰减图来修改检测到的声信号的至少一部分; 以及基于经修改的声信号产生组织体积的反射呈现。

公开(公告)号：US20080229832A1

公开(公告)日：2008-09-25

申请号：US12033789

申请日：2008-02-19

申请人： Lianjie Huang ,  Cuiping Li

发明人： Lianjie Huang ,  Cuiping Li

IPC分类号： G01N29/00 ,  A61B8/13

CPC分类号： A61B8/5207 ,  A61B8/13 ,  G01B17/00

摘要： Ultrasound sound-speed tomography requires accurate picks of time-of-flights (TOFs) of transmitted ultrasound signals, however, manual picking on large datasets is time-consuming. An improved automatic TOF picker is taught based on the Akaike Information Criterion (AIC) and multi-model inference (model averaging), based on the calculated AIC values, to improve the accuracy of TOF picks. The automatic TOF picker of the present invention can accurately pick TOFs in the presence of random noise with average absolute amplitude of up to 80% of the maximum absolute synthetic signal amplitude. The inventive method is applied to clinical ultrasound breast data, and compared with manual picks and amplitude threshold picking. Test results indicate that the inventive TOF picker is much less sensitive to data signal-to-noise ratios (SNRs), and performs more consistently for different datasets in relation to manual picking. The technique provides noticeably improved image reconstruction accuracy.

摘要翻译： 超声声速断层扫描需要精确选择发射超声信号的飞行时间（TOF），然而，在大数据集上的手动选取是耗时的。 基于计算的AIC值，基于Akaike信息准则（AIC）和多模型推理（模型平均）来教授改进的自动TOF选择器，以提高TOF拾取的准确性。 本发明的自动TOF选择器可以在平均绝对幅度高达最大绝对合成信号幅度的80％的随机噪声存在的情况下精确地选择TOF。 本发明方法应用于临床超声乳腺数据，并与手动选取和幅度阈值选择进行比较。 测试结果表明本发明的TOF选择器对数据信噪比（SNR）的敏感性要低得多，并且对于不同的数据集相对于手动拾取而言更为一致。 该技术提供了显着提高的图像重建精度。

公开(公告)号：US20100168407A1

公开(公告)日：2010-07-01

申请号：US12063227

申请日：2006-07-24

申请人： Pengcheng Li ,  Zhanyong Guo ,  Song Liu ,  Ronge Xing ,  Huahua Yu ,  Pibo Wang ,  Xiaolin Chen ,  Cuiping Li

发明人： Pengcheng Li ,  Zhanyong Guo ,  Song Liu ,  Ronge Xing ,  Huahua Yu ,  Pibo Wang ,  Xiaolin Chen ,  Cuiping Li

IPC分类号： C08B37/08

CPC分类号： A01N43/16 ,  A61K31/14 ,  C08B37/003

摘要： The invention relates to a novel kind of chitosan derivative, specifically to quaternized carboxymethyl chitosand derivatives and preparation method. Chitosan with different molecular weight reacts with chloroactic acid give rise to carboxymethyl chitosan. After reaction of Schiff based, deoxidized and quaternized, quaternized carboxymethyl chitosan is obtained. This kind of chitosan derivative have better water-solubility and better antifungal activity, which can used in the fields of medicine and agriculture.

摘要翻译： 本发明涉及一种新型壳聚糖衍生物，特别涉及季铵化羧甲基壳聚糖衍生物及其制备方法。 不同分子量的壳聚糖与氯代酸反应产生羧甲基壳聚糖。 在基于Schiff的基础上，脱氧和季铵化后，得到季铵化的羧甲基壳聚糖。 这种壳聚糖衍生物具有更好的水溶性和更好的抗真菌活性，可用于医药和农业领域。

公开(公告)号：US09113835B2

公开(公告)日：2015-08-25

申请号：US13368169

申请日：2012-02-07

申请人： Cuiping Li

发明人： Cuiping Li

IPC分类号： A61B8/15 ,  G06T7/00 ,  A61B8/08 ,  A61B8/00

CPC分类号： A61B8/15 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/4444 ,  A61B8/4483 ,  A61B8/4494 ,  A61B8/5207 ,  A61B8/587 ,  G06T7/0012 ,  G06T7/32 ,  G06T7/344

摘要： The system of one embodiment for imaging tissue includes ultrasound emitters configured to surround and emit acoustic waveforms toward the tissue, ultrasound receivers configured to surround and receive acoustic waveforms scattered by the tissue, and a processor configured for determining an observed differential time-of-flight (ToF) dataset and generating an acoustic speed rendering of the tissue based on the observed differential ToF dataset. The method of one embodiment for imaging tissue includes receiving data representative of acoustic waveforms scattered by the tissue, determining an observed differential ToF dataset, performing forward modeling to generate a calculated differential ToF dataset based on an acoustic speed model, performing inverse modeling to generate an acoustic speed model based on the observed and calculated differential ToF datasets, iteratively repeating forward modeling and inverse modeling until convergence is met with a final acoustic speed model, and generating an acoustic speed rendering from the final acoustic speed model.

摘要翻译： 用于成像组织的一个实施例的系统包括超声发射器，其被配置为围绕并向组织发出声波形，被配置为围绕和接收由组织散射的声波的超声波接收器，以及被配置为确定观察到的差分飞行时间 （ToF）数据集，并且基于观察到的差分ToF数据集产生组织的声速渲染。 用于成像组织的一个实施例的方法包括接收表示由组织散射的声波的数据，确定观察到的差分ToF数据集，执行正向建模以基于声速模型生成计算的差分ToF数据集，执行逆建模以生成 基于观测和计算的差分ToF数据集的声速模型，迭代重复前向建模和反向建模，直到满足最终声速模型，并从最终声速模型生成声速渲染。

公开(公告)号：US20120283566A1

公开(公告)日：2012-11-08

申请号：US13368169

申请日：2012-02-07

申请人： Cuiping Li

发明人： Cuiping Li

IPC分类号： A61B8/15

CPC分类号： A61B8/15 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/4444 ,  A61B8/4483 ,  A61B8/4494 ,  A61B8/5207 ,  A61B8/587 ,  G06T7/0012 ,  G06T7/32 ,  G06T7/344

摘要： The system of one embodiment for imaging tissue includes ultrasound emitters configured to surround and emit acoustic waveforms toward the tissue, ultrasound receivers configured to surround and receive acoustic waveforms scattered by the tissue, and a processor configured for determining an observed differential time-of-flight (ToF) dataset and generating an acoustic speed rendering of the tissue based on the observed differential ToF dataset. The method of one embodiment for imaging tissue includes receiving data representative of acoustic waveforms scattered by the tissue, determining an observed differential ToF dataset, performing forward modeling to generate a calculated differential ToF dataset based on an acoustic speed model, performing inverse modeling to generate an acoustic speed model based on the observed and calculated differential ToF datasets, iteratively repeating forward modeling and inverse modeling until convergence is met with a final acoustic speed model, and generating an acoustic speed rendering from the final acoustic speed model.

摘要翻译： 用于成像组织的一个实施例的系统包括超声发射器，其被配置为围绕并向组织发出声波形，被配置为围绕和接收由组织散射的声波的超声波接收器，以及被配置为确定观察到的差分飞行时间 （ToF）数据集，并且基于观察到的差分ToF数据集产生组织的声速渲染。 用于成像组织的一个实施例的方法包括接收表示由组织散射的声波的数据，确定观察到的差分ToF数据集，执行正向建模以基于声速模型生成计算的差分ToF数据集，执行逆建模以生成 基于观测和计算的差分ToF数据集的声速模型，迭代重复前向建模和逆建模，直到满足最终声速模型，并从最终声速模型生成声速渲染。