公开(公告)号：US08277110B2

公开(公告)日：2012-10-02

申请号：US12588194

申请日：2009-10-07

申请人： Gwo-Bin Lee ,  Sung-Yi Yang

发明人： Gwo-Bin Lee ,  Sung-Yi Yang

IPC分类号： B01F5/02

CPC分类号： B01F5/0068 ,  B01F11/0071 ,  B01F13/0059

摘要： The present invention provides a micromixer biochip, comprising: a substrate having a surface; a fluidic channel layer disposed above the surface of the substrate, including a mixing chamber and a single-opening fluidic channel, wherein one end of the single-opening fluidic channel is closed and the other end of the single-opening fluidic channel connects to the mixing chamber, and a top portion of the single-opening fluidic channel is made of a flexible material; and an air chamber layer disposed above the top portion of the fluidic channel layer, including an air pore, at least one chamber, and an air channel connecting the chamber and the air pore, wherein the number and position of the air chamber correspond to the number and position of the single-opening fluidic channel of the fluidic channel layer.

摘要翻译： 本发明提供一种微混合器生物芯片，包括：具有表面的基底; 设置在所述基板的表面上方的流体通道层，包括混合室和单开口流体通道，所述单开口流体通道的一端封闭，并且所述单开口流体通道的另一端连接到 混合室，单开口流体通道的顶部由柔性材料制成; 以及设置在流体通道层的顶部上方的空气室层，包括空气孔，至少一个室和连接室和空气孔的空气通道，其中空气室的数量和位置对应于 流体通道层的单开口流体通道的数量和位置。

公开(公告)号：US20100246315A1

公开(公告)日：2010-09-30

申请号：US12588194

申请日：2009-10-07

申请人： Gwo-Bin Lee ,  Sung-Yi Yang

发明人： Gwo-Bin Lee ,  Sung-Yi Yang

IPC分类号： B01F5/06 ,  B01F13/02

CPC分类号： B01F5/0068 ,  B01F11/0071 ,  B01F13/0059

摘要： The present invention provides a micromixer biochip, comprising: a substrate having a surface; a fluidic channel layer disposed above the surface of the substrate, including a mixing chamber and a single-opening fluidic channel, wherein one end of the single-opening fluidic channel is closed and the other end of the single-opening fluidic channel connects to the mixing chamber, and a top portion of the single-opening fluidic channel is made of a flexible material; and an air chamber layer disposed above the top portion of the fluidic channel layer, including an air pore, at least one chamber, and an air channel connecting the chamber and the air pore, wherein the number and position of the air chamber correspond to the number and position of the single-opening fluidic channel of the fluidic channel layer

摘要翻译： 本发明提供一种微混合器生物芯片，包括：具有表面的基底; 设置在所述基板的表面上方的流体通道层，包括混合室和单开口流体通道，所述单开口流体通道的一端封闭，并且所述单开口流体通道的另一端连接到 混合室，单开口流体通道的顶部由柔性材料制成; 以及设置在流体通道层的顶部上方的空气室层，包括空气孔，至少一个室和连接室和空气孔的空气通道，其中空气室的数量和位置对应于 流体通道层的单开口流体通道的数量和位置

公开(公告)号：US08911989B2

公开(公告)日：2014-12-16

申请号：US12795445

申请日：2010-06-07

申请人： Gwo-Bin Lee ,  Sung-Yi Yang ,  Song-Bin Huang ,  Kang-Yi Lien ,  Chen-Hsun Weng

发明人： Gwo-Bin Lee ,  Sung-Yi Yang ,  Song-Bin Huang ,  Kang-Yi Lien ,  Chen-Hsun Weng

IPC分类号： C12M1/00 ,  C12P19/34 ,  B01L3/00 ,  B01F11/00 ,  B01F13/00 ,  F16K99/00 ,  B01L7/00

CPC分类号： F16K99/0001 ,  B01F11/0071 ,  B01F13/0059 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2300/0819 ,  B01L2300/0867 ,  B01L2400/043 ,  B01L2400/049 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/0396

摘要： The present invention provides a microfluidic biochip, which comprises: a fluid transportation unit having a fluid transportation reservoir and a fluid transportation air chamber; a first fluid storage reservoir; a second fluid storage reservoir; a first valve unit having a first valve and a first valve control air chamber; and a second valve unit having a second valve and a second valve control air chamber; wherein the first valve unit is located between the first fluid storage reservoir and the fluid transportation unit, the second valve unit is located between the second fluid storage reservoir and the fluid transportation unit, and the top portion of the fluid transportation reservoir and the valves are made of a flexible material. The structure of the present microfluidic biochip allows fluids to be transported and/or mixed therein.

摘要翻译： 本发明提供了一种微流体生物芯片，其包括：流体输送单元，其具有流体输送储存器和流体输送空气室; 第一流体储存容器; 第二流体储存容器; 第一阀单元，具有第一阀和第一阀控制空气室; 以及具有第二阀和第二阀控制空气室的第二阀单元; 其中所述第一阀单元位于所述第一流体储存容器和所述流体输送单元之间，所述第二阀单元位于所述第二流体储存容器和所述流体输送单元之间，并且所述流体输送储存器的顶部和所述阀为 由柔性材料制成。 本发明微流体生物芯片的结构允许流体在其中运输和/或混合。

公开(公告)号：US08350243B2

公开(公告)日：2013-01-08

申请号：US12461899

申请日：2009-08-27

申请人： Gwo-Bin Lee ,  Tzung-Fang Guo ,  Wei Wang ,  Yen-Heng Lin

发明人： Gwo-Bin Lee ,  Tzung-Fang Guo ,  Wei Wang ,  Yen-Heng Lin

IPC分类号： G01N21/86 ,  G01V8/00

CPC分类号： G01N27/447 ,  B03C5/005 ,  B03C5/026

摘要： An optically-induced dielectrophoresis chip including a substrate, a first electrode layer disposed on the substrate, and an interface modification layer disposed on the first electrode layer. A photo-conductive layer is disposed on the interface modification layer and includes an optical absorbent polymeric material. A barrier layer is disposed on the photo-conductive layer, and a compartment forming layer is disposed on the barrier layer defining a compartment. A second electrode layer covers the compartment forming layer.

摘要翻译： 一种光诱导介电电泳芯片，其包括基板，设置在基板上的第一电极层和设置在第一电极层上的界面改性层。 光导电层设置在界面改性层上并且包括光学吸收聚合材料。 阻挡层设置在光导层上，隔层形成层设置在限定隔间的势垒层上。 第二电极层覆盖隔室形成层。

公开(公告)号：US09086409B2

公开(公告)日：2015-07-21

申请号：US12659422

申请日：2010-03-09

申请人： Gwo-Bin Lee ,  Huan-Yao Lei ,  Yu-Fang Lee ,  Kang-Yi Lien

发明人： Gwo-Bin Lee ,  Huan-Yao Lei ,  Yu-Fang Lee ,  Kang-Yi Lien

IPC分类号： G01N33/543

CPC分类号： G01N33/54386 ,  B01F11/0051 ,  B01F13/0059

摘要： The present invention is about a microfluidic chip for rapid detection of different target proteins and a method for using the same. The microfluidic chip utilizes antibody-conjugated magnetic beads to bind to the target proteins to form a magnetic complex, and then use the signal labeled-antibodies that can recognize said magnetic complex. Purifying said magnetic complex by the micro-magnetic field on biochip, and introducing said purified magnetic complex into the fluorescent detection area on the chip to detect the amount of the target protein in said purified complex immediately.

摘要翻译： 本发明涉及用于快速检测不同靶蛋白的微流控芯片及其使用方法。 微流体芯片利用抗体缀合的磁珠结合靶蛋白以形成磁性复合物，然后使用可识别所述磁性复合物的信号标记的抗体。 通过生物芯片上的微磁场对所述磁性复合物进行纯化，并将所述纯化的磁性复合物引入芯片上的荧光检测区域，以立即检测所述纯化复合物中靶蛋白的量。

公开(公告)号：US20120209053A1

公开(公告)日：2012-08-16

申请号：US13358824

申请日：2012-01-26

申请人： Gwo-Bin Lee ,  Xi-Zhang Lin ,  Sheng-Chieh Huang ,  Yi-Yuan Chang ,  Yan-Shen Shan ,  Sheng-Jye Hwang ,  Tung-Jen Lee ,  Szu-Yin Chen ,  Ping-Hen Chen

发明人： Gwo-Bin Lee ,  Xi-Zhang Lin ,  Sheng-Chieh Huang ,  Yi-Yuan Chang ,  Yan-Shen Shan ,  Sheng-Jye Hwang ,  Tung-Jen Lee ,  Szu-Yin Chen ,  Ping-Hen Chen

IPC分类号： A61N2/02

CPC分类号： A61B18/04 ,  A61B2018/00589

摘要： An electromagnetic thermotherapeutic apparatus includes: a plurality of needle units respectively having head portions and needle portions; a base unit having a base plate that is formed with a plurality of first through holes, and a base pad that is formed with a plurality of second through holes, the needle portions of the needle units removably extending through the second and first through holes, the head portions of the needle units abutting against the base pad; a temperature monitor disposed between the base plate and the base pad; an upper unit disposed above the base pad and abutting against the head portions; and a clamp unit clamping and pressing the base unit against the upper unit.

摘要翻译： 一种电磁热治疗装置，包括：分别具有头部和针部的多个针单元; 具有形成有多个第一通孔的基板的基座单元和形成有多个第二通孔的基座，所述针单元的针部可移除地延伸穿过第二通孔和第一通孔， 针单元的头部抵靠基座; 设置在所述基板和所述基座之间的温度监视器; 上部单元，设置在所述基座的上方并抵靠所述头部; 夹紧单元夹紧并将基座压靠在上部单元上。

公开(公告)号：US08021582B2

公开(公告)日：2011-09-20

申请号：US12548365

申请日：2009-08-26

申请人： Gwo-Bin Lee ,  Cheng-Tso Chen

发明人： Gwo-Bin Lee ,  Cheng-Tso Chen

IPC分类号： B29B9/00

CPC分类号： B01J19/0093 ,  B01F3/0807 ,  B01F11/0042 ,  B01F13/0062 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00889 ,  B01J2219/00907

摘要： A continuous phase liquid and a dispersed phase liquid are permitted to flow together through a co-flow channel. Preferably, the dispersed phase liquid is arranged to flow within the flowing body of the continuous phase liquid in the co-flow channel so that the dispersed phase liquid is sheathed by the continuous phase liquid. The continuous phase and dispersed phase liquids are comminuted into microparticles in the co-flow channel by intermittently blocking the co-flow channel.

摘要翻译： 允许连续相液体和分散相液体通过共流通道一起流动。 优选地，分散相液体布置成在共流通道中在连续相液体的流动体内流动，使得分散相液体被连续相液体包覆。 连续相和分散相液体通过间歇地阻塞共流通道而在共流通道中粉碎成微粒。

公开(公告)号：US20070000548A1

公开(公告)日：2007-01-04

申请号：US11338193

申请日：2006-01-23

申请人： Gwo-Bin Lee ,  Cheng-Tso Chen

发明人： Gwo-Bin Lee ,  Cheng-Tso Chen

IPC分类号： F15C1/08

CPC分类号： B01F3/0807 ,  B01F13/0062 ,  Y10T137/2207

摘要： A continuous phase liquid and a dispersed phase liquid are permitted to flow together through a co-flow channel. Preferably, the dispersed phase liquid is arranged to flow within the flowing body of the continuous phase liquid in the co-flow channel. The continuous phase and dispersed phase liquids are comminuted intermittently by intermittently moving a comminuting member transversely into the co-flow channel, thereby producing microparticles of the dispersed phase liquid. A chip device for producing the microparticles is also disclosed.

摘要翻译： 允许连续相液体和分散相液体通过共流通道一起流动。 优选地，分散相液体布置成在共流动通道中在连续相液体的流动体内流动。 连续相和分散相液体通过间歇地将粉碎部件横向移动到共流通道中间歇地粉碎，从而产生分散相液体的微粒。 还公开了一种用于生产微粒的芯片器件。

公开(公告)号：US06577431B2

公开(公告)日：2003-06-10

申请号：US09880813

申请日：2001-06-15

申请人： Cheng-Tang Pan ,  Shin-Chou Chen ,  Gwo-Bin Lee ,  Hsien-Min Yang ,  Chen-Sho Shey

发明人： Cheng-Tang Pan ,  Shin-Chou Chen ,  Gwo-Bin Lee ,  Hsien-Min Yang ,  Chen-Sho Shey

IPC分类号： G02F109

CPC分类号： B81B3/0062 ,  G02B26/0833 ,  G02B26/0841 ,  G02B26/085 ,  G02B26/0866 ,  H01H50/005

摘要： A system of angular displacement control for micro mirrors includes a stationary vertical element, a stationary horizontal element and an interference eliminator. Alternatively, the stationary horizontal element holds micro mirrors in place during transportation for avoiding vibration and collision. The stationary vertical element orientates the micro mirrors in the vertical position. The interference eliminator eliminates magnetic interference that could affect the operation of the micro mirrors. The micro mirrors having interference eliminators are capable of remaining unaffected by operations of other micro mirrors.

公开(公告)号：US08624008B2

公开(公告)日：2014-01-07

申请号：US12924225

申请日：2010-09-22

申请人： Gwo-Bin Lee ,  Shu-Chu Shiesh ,  Chao-June Huang ,  Hsin-I Lin

发明人： Gwo-Bin Lee ,  Shu-Chu Shiesh ,  Chao-June Huang ,  Hsin-I Lin

IPC分类号： C07H21/02

CPC分类号： G01N33/68 ,  C07K14/4737 ,  G01N2333/4737

摘要： An aptamer specifically binding to C-reactive protein (CRP) is provided. The aptamer includes a following nucleotide sequence: 5′-angngggngnntgnnt-3′, wherein n is a nucleotide selected from a, t, c and g.

摘要翻译： 提供了特异性结合C反应蛋白（CRP）的适体。 适体包括以下核苷酸序列：5'-angngggngnntntntnt-3'，其中n是选自a，t，c和g的核苷酸。