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    Method of treatment of cancer
    1.
    发明申请
    Method of treatment of cancer 审中-公开
    癌症治疗方法

    公开(公告)号：US20090117199A1

    公开(公告)日：2009-05-07

    申请号：US12315781

    申请日：2008-12-05

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K33/42 ,  A61K33/14 ,  A61P35/00

    CPC分类号： A61K31/352 ,  A61K9/0019

    摘要： A method for the treatment of cancer, particularly a metastatic melanoma or a neoplastic lesion, the method comprising intralesional administration of a hydrophilic vehicle comprising 4,5,6,7-Tetrachloro-2′,4′,5′,7′-tetraiodofluorescein, or a physiologically acceptable salt thereof, at a concentration of about 0.1 w/v % up to about 20 w/v % and an electrolyte comprising at least one cation selected from the group consisting of sodium, potassium, calcium and magnesium and at least one anion selected from the group consisting of chlorine, a phosphate and a nitrate, wherein the electrolyte is at a concentration of between about 0.1 w/v % and about 2 w/v % and the pH of the solution between about 4 to about 10.

    摘要翻译： 一种治疗癌症，特别是转移性黑色素瘤或肿瘤性病变的方法，所述方法包括病灶内施用包含4,5,6,7-四氯-2'，4'，5'，7'-四碘荧光素的亲水载体 或其生理上可接受的盐，浓度为约0.1w / v％至约20w / v％，以及包含至少一种选自钠，钾，钙和镁的阳离子的电解质，并且至少 一个选自氯，磷酸盐和硝酸盐的阴离子，其中电解质的浓度为约0.1w / v％至约2w / v％，溶液的pH为约4至约10 。

    Medicaments for Chemotherapeutic Treatment of Disease
    3.
    发明申请
    Medicaments for Chemotherapeutic Treatment of Disease 失效
    化疗药物治疗疾病

    公开(公告)号：US20080118567A1

    公开(公告)日：2008-05-22

    申请号：US11951800

    申请日：2007-12-06

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K31/352 ,  A61P35/04 ,  A61K9/14

    CPC分类号： A61K9/0019 ,  A61K31/352

    摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的化学治疗药物和某些医疗用途以及用于治疗人或动物组织中的这种化学治疗药物的方法，其中这种药物的主要活性成分是卤化呫吨或卤代呫吨衍生物。 优选地，卤代呫吨是玫瑰红或玫瑰红的功能衍生物。 卤代呫吨构成一系列有用的化学治疗剂，其在某些组织中提供选择性的，持续的积累。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统 内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个优选的实施方案中，这些药物可用于体内或局部给药的各种制剂，包括在液体，半固体，固体或气溶胶输送载体中。

    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
    4.
    发明授权
    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents 有权
    用放射性标记的卤代呫吨酶诊断剂进行正电子发射成像的方法

    公开(公告)号：US07338652B2

    公开(公告)日：2008-03-04

    申请号：US11050512

    申请日：2005-02-03

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K49/04

    CPC分类号： A61K51/0421

    摘要： New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.

    摘要翻译： 描述了用于正电子发射断层摄影（PET）的新诊断剂和用于这种药剂用于人或动物组织成像的方法，其中这种药剂的主要活性成分是放射性标记的卤化呫吨或卤代呫吨衍生物。 优选地，放射性标记的卤代呫吨是放射性标记的玫瑰红或玫瑰红的功能衍生物。

    Intracorporeal Medicaments for High Energy Phototherapeutic Treatment of Disease
    7.
    发明申请
    Intracorporeal Medicaments for High Energy Phototherapeutic Treatment of Disease 审中-公开
    体内高能量光疗治疗疾病的药物

    公开(公告)号：US20100076246A1

    公开(公告)日：2010-03-25

    申请号：US12543653

    申请日：2009-08-19

    申请人： H. Craig Dees ,  Timothy C. Scott ,  Eric A. Wachter ,  Walter G. Fisher ,  John Smolik

    发明人： H. Craig Dees ,  Timothy C. Scott ,  Eric A. Wachter ,  Walter G. Fisher ,  John Smolik

    IPC分类号： A61N5/10 ,  A61K31/352 ,  A61P35/04

    CPC分类号： A61K31/352 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61K9/0019 ,  A61K41/0038 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/1098 ,  C07D311/82

    摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的体内放射碘化物药物和用于治疗人或动物组织的这种高能光疗药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤化呫吨衍生物。 卤化呫吨构成了一种有效的放射增敏剂，其在用电离辐射照射治疗部位时变得光活化。 在本发明的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官的各种病症， 循环系统和相关器官，头颈部，内分泌和淋巴系统及相关器官，各种其他组织，例如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个实施方案中，这些药物是以包括液体，半固体，固体或气溶胶输送载体在内的各种制剂生产的。

    Medicaments for chemotherapeutic treatment of disease
    8.
    发明授权
    Medicaments for chemotherapeutic treatment of disease 失效
    化疗药物治疗疾病

    公开(公告)号：US07648695B2

    公开(公告)日：2010-01-19

    申请号：US09900355

    申请日：2001-07-06

    申请人： H. Craig Dees ,  Timothy C. Scott

    发明人： H. Craig Dees ,  Timothy C. Scott

    IPC分类号： A61K51/00 ,  A61M36/14 ,  G01N33/00

    CPC分类号： A61K41/0057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0071 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y02A50/473 ,  Y10T436/193333

    摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的化学治疗药物和用于治疗人或动物组织中的这种化学治疗药物的某些医疗用途和方法，其中这种药物的主要活性成分是卤化呫吨或卤代呫吨衍生物。 优选地，卤代呫吨是玫瑰红或玫瑰红的功能衍生物。 卤代呫吨构成一系列有用的化学治疗剂，其在某些组织中提供选择性的，持续的积累。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统 内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个优选的实施方案中，这些药物可用于体内或局部给药的各种制剂，包括在液体，半固体，固体或气溶胶输送载体中。

    Topical Medicaments and Methods for Photodynamic Treatment of Disease
    10.
    发明申请
    Topical Medicaments and Methods for Photodynamic Treatment of Disease 有权
    光动力治疗疾病的专题药物和方法

    公开(公告)号：US20080118578A1

    公开(公告)日：2008-05-22

    申请号：US11936963

    申请日：2007-11-08

    申请人： H. Craig Dees ,  Timothy C. Scott ,  John Smolik ,  Eric A. Wachter ,  Walter G. Fisher

    发明人： H. Craig Dees ,  Timothy C. Scott ,  John Smolik ,  Eric A. Wachter ,  Walter G. Fisher

    IPC分类号： A61K33/14 ,  A61P43/00

    CPC分类号： A61K31/352 ,  A61K33/14 ,  A61K41/00 ,  A61K2300/00

    摘要： New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

    摘要翻译： 描述了用于治疗人或动物组织的新的光动力学，局部适用药物和这种光动力药物的某些医学用途，其中这种药物的主要活性成分是卤代呫吨。 卤化呫吨构成了一系列有效的光敏剂，在用可见光波长照射治疗部位时变得光活化。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官的各种病症; 口腔和消化道及相关器官; 泌尿生殖道及相关器官; 呼吸道及相关器官; 各种其他内部或外部组织表面，例如在手术期间暴露的组织表面; 并用于治疗与微生物或寄生虫感染有关的各种病症。 在另一个优选的实施方案中，这种药物是以包括液体，半固体或气溶胶递送载体在内的各种制剂生产的。