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公开(公告)号：US20240214702A1
公开(公告)日：2024-06-27
申请号：US18382165
申请日：2023-10-20
发明人： Satoshi YAMAMOTO
IPC分类号： H04N25/531 , H04N23/56 , H04N23/76
CPC分类号： H04N25/531 , H04N23/56 , H04N23/76
摘要： In a sample observation device, an image capturing unit includes an area image sensor that performs image capturing by the rolling shutter method in which a start of an exposure period of each of pixel columns in a pixel region is shifted by a predetermined time, and a generation unit sets one pixel column of the pixel columns as a reference pixel column, and combines a data portion corresponding to an exposure position of the reference pixel column in exposure positions of pixel columns of one frame and the data portion corresponding to an exposure position of the reference pixel column in exposure positions of pixel columns of other frames continuous to the one frame, thereby generating two-dimensional image data corresponding to the exposure position of the reference pixel column in the one frame.
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公开(公告)号：US20230314782A1
公开(公告)日：2023-10-05
申请号：US18206518
申请日：2023-06-06
发明人： Satoshi YAMAMOTO
CPC分类号： G02B21/008 , G01N21/49 , G01N21/6428 , G01N21/6456 , G02B21/0032 , G02B21/0076 , G06T5/002 , G06T5/50 , G01N2021/6439 , G06T2207/10056 , G06T2207/20224
摘要： A sample observation device includes: an emission optical system that emits planar light to a sample on an XZ plane; a scanning unit that scans the sample in a Y-axis direction so as to pass through an emission surface of the planar light; an imaging optical system that has an observation axis inclined with respect to the emission surface and forms an image of observation light generated in the sample; an image acquisition unit that acquires a plurality of pieces of XZ image data corresponding to an optical image of the observation light; and an image generation unit that generates XY image data based on the plurality of pieces of XZ image data. The image generation unit extracts an analysis region of the plurality of pieces of XZ image data acquired in the Y-axis direction, integrates brightness values of at least the analysis region in a Z-axis direction to generate X image data, and combines the X image data in the Y-axis direction to generate the XY image data.
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3.发明申请公开(公告)号：US20190121013A1
公开(公告)日：2019-04-25
申请号：US16217354
申请日：2018-12-12
发明人： Satoshi YAMAMOTO , Kenshi FUKUMITSU
IPC分类号： F21V8/00 , A61B5/1455 , G01N21/49 , B23K26/03 , G02B6/00 , G01N33/483 , G01N21/64 , G01N21/55 , G01N21/47 , G01N21/27 , G01N21/25 , G01N21/03 , G01N21/01 , F21S2/00 , B23K26/53
摘要： An optical plate is an optical plate for irradiating a target with light, and includes a light input surface for inputting the light, a light output surface for outputting the light, a back surface opposite to the light output surface, and a light diffusion portion formed at least inside the optical plate by converging laser light, for diffusing the light. The light input surface is a surface between the light output surface and the back surface, and the light input from the light input surface is diffused in the light diffusion portion and output from the light output surface.
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4.发明申请公开(公告)号：US20170146720A1
公开(公告)日：2017-05-25
申请号：US15313195
申请日：2015-05-15
发明人： Satoshi YAMAMOTO , Kenshi FUKUMITSU
IPC分类号： F21V8/00 , B23K26/00 , B23K26/03 , G01N33/483 , G01N21/55 , G01N21/64 , G01N21/03 , B23K26/53 , G01N21/47
CPC分类号： G02B6/0035 , A61B5/1455 , B23K26/032 , B23K26/53 , F21S2/00 , G01N21/01 , G01N21/03 , G01N21/253 , G01N21/27 , G01N21/47 , G01N21/49 , G01N21/55 , G01N21/64 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N33/4833 , G01N2201/06113 , G01N2201/068 , G02B6/00
摘要： An optical plate is an optical plate for irradiating a target with light, and includes a light input surface for inputting the light, a light output surface for outputting the light, a back surface opposite to the light output surface, and a light diffusion portion formed at least inside the optical plate by converging laser light, for diffusing the light. The light input surface is a surface between the light output surface and the back surface, and the light input from the light input surface is diffused in the light diffusion portion and output from the light output surface.
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公开(公告)号：US20220205913A1
公开(公告)日：2022-06-30
申请号：US17699834
申请日：2022-03-21
IPC分类号： G01N21/64
摘要： A sample observation device includes a sample container that holds the sample stained with a first fluorescent substance and a solution including a second fluorescent substance, an irradiation unit that performs irradiation with first excitation light and second excitation light, a scanning unit that scans the sample container in one direction, an image formation unit that forms first fluorescent light from the sample and second fluorescent light from the solution, an imaging unit that outputs first image data based on the first fluorescent light and first image data based on the second fluorescent light, an image processing unit that generates a first fluorescent light image based on a plurality of pieces of first image data and a second fluorescent light image based on a plurality of pieces of second image data, and an analysis unit that specifies an area in which there is the sample on the basis of the second fluorescent light image and sets an analysis area in the first fluorescent light image.
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公开(公告)号：US20210026121A1
公开(公告)日：2021-01-28
申请号：US17040091
申请日：2019-01-30
发明人： Satoshi YAMAMOTO
摘要： A sample observation device includes: an emission optical system that emits planar light to a sample on an XZ plane; a scanning unit that scans the sample in a Y-axis direction so as to pass through an emission surface of the planar light; an imaging optical system that has an observation axis inclined with respect to the emission surface and forms an image of observation light generated in the sample; an image acquisition unit that acquires a plurality of pieces of XZ image data corresponding to an optical image of the observation light; and an image generation unit 8 that generates XY image data based on the plurality of pieces of XZ image data. The image generation unit extracts an analysis region of the plurality of pieces of XZ image data acquired in the Y-axis direction, integrates brightness values of at least the analysis region in a Z-axis direction to generate X image data, and combines the X image data in the Y-axis direction to generate the XY image data.
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公开(公告)号：US20210018735A1
公开(公告)日：2021-01-21
申请号：US16981564
申请日：2019-01-30
发明人： Satoshi YAMAMOTO
摘要： In a sample observation device, when the angle formed by an optical axis of an emission optical system and a normal of a scanning surface is θ1 and the angle formed by an optical axis of an imaging optical system and the normal of the scanning surface is θ2, both θ1 and θ2 are 80° or less, and θ1+θ2 is 100° or more. In an image acquisition unit, an image acquisition region Fn+1, m+1 in the (m+1)-th frame of the (n+1)-th pixel is shifted from an image acquisition region Fn, m in the m-th frame of the n-th pixel in a scanning direction of a sample according to the scanning amount of the sample in the exposure time of one frame.
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公开(公告)号：US20240184090A1
公开(公告)日：2024-06-06
申请号：US18285528
申请日：2022-03-17
发明人： Satoshi YAMAMOTO
CPC分类号： G02B21/0032 , G02B21/0036 , G02B21/008 , G02B21/361 , G02B21/365 , H04N23/10 , H04N23/56
摘要： A sample observation device includes an irradiation optical system that emits planar light and having different wavelengths so as to pass through cross sections at different positions of the sample, a scanning unit that scans the sample with respect to the irradiation surfaces and, an imaging optical system that has an observation axis inclined with respect to the irradiation surfaces and images each of light images of observation light, an image acquiring unit that acquires each of first image data and second image data during scanning of the sample by the scanning unit, and an image generating unit that generates observation image data and the sample on the basis of the first image data and the second image data.
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公开(公告)号：US20220283420A1
公开(公告)日：2022-09-08
申请号：US17751818
申请日：2022-05-24
摘要： A sample observation device (1) includes: an emission optical system (3) for emitting planar light (L2) onto a sample (S); a scanning unit (4) for scanning the sample (S) with respect to an emission face (R) of the planar light (L2); an imaging optical system (5) having an observation axis (P2) inclined with respect to the emission face (R) and for forming an image from observation light (L3) generated in the sample (S) in accordance with the emission of the planar light (L2); an image acquiring unit (6) for acquiring a plurality of partial image data corresponding to a part of an optical image according to the observation light (L3) formed as an image by the imaging optical system (5); and an image generating unit (8) for generating observation image data of the sample S based on the plurality of partial image data generated by the image acquiring unit (6).
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公开(公告)号：US20210116373A1
公开(公告)日：2021-04-22
申请号：US16629326
申请日：2018-04-10
摘要： A sample observation device includes an imaging unit that images observation light generated due to irradiation with the planar light that is transmitted through a membrane filter and outputs fluorescent light image data, a partial image generation unit that specifies a first area corresponding to a first sample holding space and a second area corresponding to a second sample holding space in the fluorescent light image data, and generates first partial image data corresponding to the first area and second partial image data corresponding to the second area, an observation image generation unit that generates first observation image data and second observation image data on the basis of the partial image data, and an analysis unit that analyzes a sample on the basis of the first observation image data and the second observation image data.
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