公开(公告)号：US20230356229A1

公开(公告)日：2023-11-09

申请号：US17909585

申请日：2020-03-30

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Carson Denison ,  Erik D. Torniainen ,  Richard W. Seaver

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/1883

Abstract: In one example in accordance with the present disclosure, a thermal cycling device is described. The thermal cycling device includes a fluid chamber to retain a fluid. A heating element is disposed around multiple sides of a cross-sectional perimeter of the fluid chamber and an insulator is disposed around multiple sides of a cross-sectional perimeter of the heating element. The thermal cycling device also includes a conductive body disposed around multiple sides of a cross-sectional perimeter of the insulator.

公开(公告)号：US20230381783A1

公开(公告)日：2023-11-30

申请号：US18032543

申请日：2020-10-19

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Erik D. Torniainen ,  Richard W. Seaver

IPC: B01L7/00 ,  C12Q1/686

CPC classification number: B01L7/525 ,  C12Q1/686 ,  B01L2300/1827 ,  B01L2400/0442 ,  B01L3/502784

Abstract: In one example in accordance with the present disclosure, a device for conducting a reaction with a fluid sample is described. The device includes: a microfluidic channel; a number of heating elements along the microfluidic channel; and an inertial pump at each of opposite ends of the microfluidic channel to oscillate the fluid sample along the microfluidic channel.

公开(公告)号：US20230381723A1

公开(公告)日：2023-11-30

申请号：US17826943

申请日：2022-05-27

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Richard W. SEAVER ,  Erik D. TORNIAINEN ,  Pavel KORNILOVICH ,  Alexander GOVYADINOV ,  Anand Samuel JEBAKUMAR ,  Oumnia EL FAJRI

IPC: B01F33/3012 ,  B01F35/71

CPC classification number: B01F33/3012 ,  B01F35/7172 ,  B01F2101/2204

Abstract: An example microfluidic mixer can include an inlet microfluidic channel portion and a fluid splitting channel portion including an overpass microfluidic channel to receive fluid from a first side of the inlet microfluidic channel portion and an underpass microfluidic channel to receive fluid from a second side of the inlet microfluidic channel portion, where the underpass microfluidic channel extends under the overpass microfluidic channel such that the channels overlap at their respective downstream ends. A fluid recombining channel portion is downstream of the fluid splitting portion and includes an angled recombining surface having an acute angle with respect to a direction of fluid flow, where the angled recombining surface is between the downstream ends of the overpass and underpass microfluidic channels. An outlet microfluidic channel portion is fluidly connected downstream from the fluid recombining channel portion.

公开(公告)号：US20240299942A1

公开(公告)日：2024-09-12

申请号：US18573690

申请日：2021-06-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Pavel Kornilovich ,  Alexander Govyadinov ,  Erik D. Torniainen ,  Richard W. Seaver ,  Anand Samuel Jebakumar

IPC: B01L3/00

CPC classification number: B01L3/502746 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/086

Abstract: A microfluidic device includes a chamber having a floor, a ceiling, and an inlet. The microfluidic device includes pillars extending from the floor to the ceiling of the chamber. Each pillar has a leading surface or corner, a trailing surface or corner opposite the leading surface or corner, and trailing side surfaces adjoining the trailing surface or corner. Each pillar is oriented along a corresponding ray intersecting the leading surface or corner and the trailing surface or corner. Adjacent pillars have a turn angle between the corresponding rays of the adjacent pillars, and each pillar has a pillar angle between the trailing side surfaces thereof. The turn and pillar angles are based on a fluidic contact angle to promote fluid flow from the inlet throughout the chamber during priming without fluidic pinning.

公开(公告)号：US20240246084A1

公开(公告)日：2024-07-25

申请号：US18559761

申请日：2021-05-10

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Alexander Govyadinov ,  Richard W. Seaver ,  Erik D. Torniainen ,  Pavel Kornilovich ,  Anand Samuel Jebakumar

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/1805 ,  B01L2300/1894

Abstract: Apparatuses may be used for nucleic acid amplification. An example apparatus may include an amplification chamber to contain a biochemical reaction associated with amplification of a biologic sample. The biologic sample may include a nucleic acid. The apparatus may also include a heater thermally coupled to the amplification chamber. The apparatus may also include a thermally conductive substrate in contact with the heater and including a liquid coolant passage to pass a liquid coolant through the thermally conductive substrate.